Abipim powder for solution for injection 1000 mg vial No. 1

Abipim powder for solution for injection in the treatment of:

Composition

Active ingredient: cefepime;

1 vial contains cefepime - 1000 mg.

(As a mixture of cefepime hydrochloride and L-arginine).

Contraindication

Hypersensitivity to cefepime or L-arginine, as well as to cephalosporin antibiotics, penicillins or other β-lactam antibiotics.

Method of application

The usual adult dosage is 1 g administered intravenously or intramuscularly at 12-hour intervals. The usual duration of treatment is 7 to 10 days; severe infections may require longer treatment.

Application features

Pregnant women

The drug is used only when the expected benefit to the mother outweighs the potential risk to the fetus.

Cefepime passes into breast milk in very low concentrations. Therefore, during breastfeeding, the drug should be used only if the expected benefit to the mother outweighs the potential risk to the child.

Drivers

Since adverse reactions from the central nervous system may occur during treatment, you should refrain from driving or operating machinery.

Children

The safety and efficacy of cefepime in the treatment of uncomplicated and complicated urinary tract infections (including pyelonephritis), uncomplicated skin infections, pneumonia, and in the empirical treatment of neutropenic fever have been established for age groups from 1 month to 16 years. The appropriateness of cefepime in these age groups is supported by the results of adequate and well-controlled studies.

Overdose

In cases of significant excess of recommended doses, especially in patients with impaired renal function, the use of hemodialysis accelerates the removal of cefepime from the body; peritoneal dialysis is ineffective.

Side effects

Cefepime is generally well tolerated, and side effects are rare, with an incidence of 0.1 - 1%.

Interaction

When using high doses of aminoglycosides concomitantly with cefepime, renal function should be closely monitored due to the potential nephrotoxicity and ototoxicity of aminoglycoside antibiotics. Nephrotoxicity has been observed after concomitant use with the diuretic furosemide.

To avoid possible drug interactions, cefepime should not be used simultaneously with solutions of metronidazole, vancomycin, gentamicin, tobramycin sulfate, and netilmicin sulfate. In case of simultaneous use with these drugs, each antibiotic should be administered separately.

Storage conditions

Store at a temperature not exceeding 25 °C.

Keep out of reach of children.

Shelf life - 2 years.