Instructions for use ACCYCLOVIR OINTMENT 2.5% TUBE 10G STM 2433 AKTS
Composition
active ingredient: acyclovir;
1 g of ointment contains acyclovir 25 mg;
excipients: polyethylene glycol 1500, polyethylene glycol 400, propylene glycol, emulsifier No. 1.
Dosage form
Ointment.
Main physicochemical properties: white ointment.
Pharmacotherapeutic group
Antiviral agents. ATX code D06B B03.
Pharmacological properties
Pharmacodynamics.
Acyclovir is an antiviral drug that has high in vitro activity against herpes simplex virus types I and II. Toxicity to host cells is minimal. Once in cells infected with herpes virus, acyclovir is phosphorylated to form the active compound acyclovir triphosphate. The first stage of this process depends on the presence of virus-encoded thymidine kinase. Acyclovir triphosphate acts as an inhibitor and substrate for viral DNA polymerase, preventing further synthesis of viral DNA without affecting normal cellular processes.
Pharmacokinetics.
The level of systemic absorption of acyclovir after repeated topical application of the ointment is minimal.
Indication
Infections of the lips and face caused by the herpes simplex virus (Herpes labialis).
Contraindication
Hypersensitivity to acyclovir, valacyclovir, propylene glycol or other components of the drug.
Interaction with other medicinal products and other types of interactions
No interaction was detected.
Application features
Accidental contact of the ointment with the eyes should be avoided.
People with herpes labialis should be warned against contact transmission of the virus to other people, especially if there are open lesions.
The drug should only be used to treat herpes on the lips and face. It is not recommended to apply the ointment to the mucous membranes of the oral cavity, eyes and to use it to treat genital herpes. Persons with particularly severe manifestations of Herpes labialis need to consult a doctor.
It is not recommended for use in immunocompromised individuals without medical advice. Such patients should seek medical advice regarding the treatment of any infection.
Use during pregnancy or breastfeeding
Pregnant and breastfeeding women are recommended to use the drug only in cases where, in the opinion of the doctor, the benefit outweighs the risk.
The ability to influence the reaction speed when driving or working with other mechanisms
No data.
Method of administration and doses
The drug is intended for external use only.
Children over 12 years of age and adults should apply the ointment 5 times a day at approximately 4-hour intervals, except at night. It is important to start treatment as early as possible at the onset of infection, best during the prodromal period or erythema stage. Treatment can also be started in the later stages - papules or blisters.
Treatment should last at least 4 days. If healing has not occurred, treatment can be extended to 10 days. If the symptoms of the disease do not disappear after 10 days of treatment, the patient should consult a doctor. Hands should be washed before and after using the ointment, and excessive rubbing or touching the affected areas with a towel should be avoided to prevent exacerbation or transmission of infection.
Children.
There is insufficient data on the safety of the drug in children under 12 years of age, so it is not recommended for use in children of this age group.
Overdose
No adverse effects have been observed with oral or topical application of the entire tube of ointment due to minimal systemic exposure. In case of suspected overdose, medical attention should be sought.
Side effects
Some patients may experience a transient, transient sharp or burning pain when applying the ointment. Approximately 5% of patients experienced minor drying and peeling of the skin. A small number of patients experienced erythema (redness) and itching. Very rarely, cases of contact dermatitis have been reported after the use of acyclovir preparations, but these cases were more often associated with the components of the ointment base, rather than with acyclovir. There are isolated reports of immediate hypersensitivity reactions, including angioedema, due to topical use of acyclovir.
Expiration date
3 years.
Do not use the drug after the expiration date indicated on the package.
Storage conditions
Store at a temperature not exceeding 25 ºС in a place inaccessible to children.
Packaging
5 g or 10 g in a tube in a pack.
Vacation category
Without a prescription.
Producer
LLC "SKP "Pharmaceutical Factory".
Address.
Ukraine, 12430, Zhytomyr region, Zhytomyr district, Stanyshivka village, Koroleva st., bldg. 4.
