Instructions Adaptol tablets 500 mg No. 20
Composition
active ingredient: mebicar;
1 tablet contains Mebicar 500 mg;
excipients: methylcellulose, calcium stearate.
Dosage form
Pills.
Main physicochemical properties: round, flat-cylindrical tablets of white or almost white color with a bevel and a score on one side of the tablet.
Pharmacotherapeutic group
Anxiolytics. ATX code N05B X.
Pharmacological properties
Pharmacodynamics
The active ingredient of the drug Adaptol® Mebicar is close in chemical structure to the body's natural metabolites - its molecule consists of two methylated urea fragments that are part of a bicyclic structure.
Adaptol® has moderate tranquilizing (anxiolytic) activity, relieves or reduces feelings of restlessness, anxiety, fear, internal emotional tension and irritation. The sedative effect of the drug is not accompanied by muscle relaxation and impaired coordination of movements. The drug does not reduce mental and motor activity, so Adaptol® can be used during the working day or study. The drug does not create an elevated mood, a feeling of euphoria. On this basis, Adaptol® is classified as a daytime tranquilizer. It does not have a hypnotic effect, but enhances the effect of hypnotics and improves sleep when it is disturbed.
In addition to its sedative effect, Adaptol® exhibits a nootropic effect. The drug improves cognitive functions, increases attention and mental performance, without stimulating the symptoms of productive psychopathological disorders - delusions, pathological emotional activity.
Adaptol® has antioxidant activity, therefore it acts as a membrane stabilizer, adaptogen and cerebroprotector in oxidative stress of various origins.
Adaptol® acts on the activity of structures that are part of the limbic-reticular complex, in particular on the emotional zones of the hypothalamus, and also affects all 4 main neurotransmitter systems – GABA, choline, serotonin – and adrenergic, which contributes to their balance and integration, but does not provide peripheral adrenonegative action. The neurotransmitter profile of Adaptol® contains a dopamine-positive component. The drug exhibits antagonistic activity against the excitation of the adrenergic and glutamatergic systems and enhances the functioning of inhibitory serotonin and GABAergic mechanisms of the brain. The drug has normastenic properties.
Adaptol® facilitates nicotine withdrawal.
Pharmacokinetics
When administered orally, bioavailability is 77–80%; up to 40% of the drug binds to erythrocytes; the remaining 60% does not bind to blood proteins and is contained in the blood plasma in a free state, due to which the drug spreads in the body without hindrance and freely passes through membranes. The maximum concentration in the blood serum is reached in 30 minutes, the high level remains for 3-4 hours, then gradually decreases. The drug is completely excreted from the body with urine during the day, does not accumulate and is not subject to biochemical transformations in the body.
Indication
Neuroses and neurosis-like conditions accompanied by irritation, emotional lability, feelings of anxiety and fear; to improve the tolerance of neuroleptics or tranquilizers in order to eliminate the somatovegetative and neurological side effects caused by them; cardialgia of various genesis (not associated with ischemic heart disease); to alleviate the course of somatovegetative manifestations in premenstrual syndrome and menopause.
Adaptol® is indicated as a cerebroprotector and adaptogen for emotional and oxidative stress of various origins.
As part of complex therapy for nicotine addiction as a means of reducing the urge to smoke.
Contraindication
Hypersensitivity to Mebicar or to any of the excipients of the drug.
Interaction with other medicinal products and other types of interactions
Adaptol® can be combined with neuroleptics, tranquilizers (benzodiazepines), hypnotics, antidepressants and psychostimulants.
Application features
Habituation, dependence, and withdrawal syndrome have not been established when using Adaptol®.
It should be used with caution in cases of impaired liver and kidney function, and in patients with arterial hypotension.
Use during pregnancy or breastfeeding
Adaptol® penetrates well into all tissues and body fluids.
There is insufficient data regarding the safety of the drug during pregnancy or breastfeeding, therefore, the drug is not recommended for pregnant and breastfeeding women.
Ability to influence reaction speed when driving vehicles or other mechanisms
Caution should be exercised when driving vehicles, as sometimes the use of the drug can cause a decrease in blood pressure.
Method of administration and doses
Adaptol® is administered orally, regardless of meals, to adults at a dose of 500 mg 2-3 times a day. If necessary, the dose can be increased.
The maximum single dose is 3 g, the maximum daily dose is 10 g.
For the treatment of tobacco addiction, the drug should be used at a dose of 500-1000 mg 3 times a day for 5-6 weeks.
Children
There is no experience of use in children.
Overdose
Adaptol® is low-toxic. In case of a significant overdose, side effects may be increased (including allergic reactions, dyspeptic disorders, weakness, temporary decrease in blood pressure and body temperature).
Treatment: gastric lavage and standard detoxification methods should be performed.
Adverse reactions
Adaptol® is usually well tolerated.
From the cardiovascular system: rarely - a decrease in blood pressure.
Gastrointestinal: rarely - dyspeptic disorders (including nausea, vomiting, diarrhea).
In this case, the dose of the drug should be reduced.
On the part of the respiratory system: rarely - bronchospasm.
Skin and subcutaneous tissue disorders: rarely - after taking large doses, allergic reactions are possible (including skin rashes, itching, urticaria, angioedema). In case of an allergic reaction, discontinue use of the drug.
General disorders: rarely - decreased body temperature, weakness, dizziness. In case of a decrease in blood pressure and/or body temperature (body temperature may decrease by 1-1.5 ° C), the drug does not need to be discontinued. Blood pressure and body temperature normalize independently.
Expiration date
4 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
10 tablets in a blister; 2 blisters in a pack.
Vacation category
According to the recipe.
Producer
JSC "Olainfarm"/JSC "Olainfarm".
Location of the manufacturer and its business address
5 Rupnicu street, Olaine, LV-2114, Latvia.
