Albendazole-Pharmex tablets are prescribed for the treatment of intestinal forms of helminthiasis and cutaneous Larva Migrans syndrome (short-term treatment with small doses): enterobiasis, hookworm and necatoriasis, hymenolepidosis, teniasis, strongyloidiasis, ascariasis, trichocephalosis, clonorchiasis, opisthorchiasis, giardiasis in children.
Composition
Active ingredient: albendazole.
1 tablet contains 400 mg of albendazole.
Excipients: microcrystalline cellulose, corn starch, lactose monohydrate, croscarmellose sodium, povidone, sodium lauryl sulfate, sodium saccharin, "Orange" flavor (flavoring substances, maltodextrin, starch sodium octenyl succinate (E 1450), glucose, butylhydroxyanisole (E 320), ascorbyl palmitate (E 304)), magnesium stearate.
Contraindication
Hypersensitivity to albendazole or to any component of the drug. Pregnancy and breastfeeding. Contraindicated in women planning to become pregnant. Women of reproductive age should use effective non-hormonal contraceptives during and for 1 month after treatment with the drug.
Method of application
The medicine should be taken with food. It is advisable to take it at the same time of day. If there is no improvement after 3 weeks, the doctor should prescribe a second course of treatment.
Some patients, especially children, may have difficulty swallowing a whole tablet - in this case, the tablet can be chewed with a small amount of water or crushed.
Application features
Pregnant women
The drug is contraindicated for use during pregnancy or breastfeeding and for the treatment of women planning to become pregnant.
Children
The medicine is intended for use in children aged 3 years and over.
Drivers
Given the likelihood of such an adverse reaction as dizziness, it is recommended to refrain from driving or operating other mechanisms during the period of use of albendazole.
Overdose
Depending on the dose of the drug taken, the following symptoms may occur: diarrhea, nausea, vomiting, tachycardia, increased transaminase levels. In case of overdose, treatment is symptomatic, according to the clinical condition.
Side effects
Immune system disorders: Rare: hypersensitivity reactions including rash, pruritus and urticaria. Nervous system disorders: Uncommon: headache and dizziness. Gastrointestinal disorders: Uncommon: upper gastrointestinal symptoms (e.g. epigastric pain, nausea, vomiting) and diarrhoea. Hepatobiliary disorders: Rare: increased liver enzymes. Skin and subcutaneous tissue disorders: Very rare: erythema multiforme, Stevens-Johnson syndrome.
Interaction
Albendazole induces enzymes of the cytochrome P450 system.
Drugs that may slightly reduce the effectiveness of albendazole: anticonvulsants (e.g. phenytoin, fosphenytoin, carbamazepine, phenobarbital, primidone), levomizol, ritonavir. Patients should be monitored for efficacy and alternative dosing regimens or therapies may be necessary.
Cimetidine, praziquantel and dexamethasone increase plasma levels of the albendazole metabolite responsible for the systemic activity of the drug, which, in turn, may lead to increased adverse reactions.
Grapefruit juice also increases the plasma levels of albendazole sulfoxide.
Due to possible disruption of cytochrome P450 activity, there is a theoretical risk of interaction with the following drugs: oral contraceptives, anticoagulants, oral hypoglycemic agents, theophylline.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life - 2 years.
