Albunorm infusion solution is indicated for restoring and maintaining circulating blood volume in volume deficits when colloid administration is indicated.
The choice of albumin over synthetic colloid should be based on official recommendations and depending on the clinical condition of the individual patient.
Composition
Active ingredient: human albumin;
: 1000 ml of infusion solution contains - 200 g of plasma proteins with a human albumin content of at least 96%;
Excipients: sodium, N-acetyl-DL-tryptophan, caprylic acid, water for injections.
Contraindication
Hypersensitivity to blood protein products or to any of the excipients.
Method of application
Albumin concentration, doses, and rate of administration should be adjusted according to the individual patient's needs.
The required dose depends on the patient's weight, the severity of the injury or illness, and the degree of fluid and protein loss. Circulating blood volume, not plasma albumin levels, should be measured to determine the required dose.
If human albumin is prescribed, geodynamic parameters should be regularly monitored, including:
blood pressure and pulse rate; central venous pressure; pulmonary artery wedge pressure; urine output; electrolyte concentration; hematocrit/hemoglobin; clinical manifestations of cardiac/respiratory failure (e.g., dyspnea); clinical manifestations of increased intracranial pressure (e.g., headache).
Albumin can be administered directly intravenously, or it can be dissolved in physiological solution (for example, in 5% glucose solution or 0.9% sodium chloride solution).
The infusion rate should be adjusted according to the condition, performance, and indications of the individual patient.
When replacing plasma, the infusion rate should be adjusted according to the rate of excretion.
When administering large volumes, the drug should be warmed to room temperature or body temperature before use.
Do not use the product if the solution is cloudy or contains a precipitate. This may indicate protein instability or contamination of the solution.
Do not use the product if the packaging is damaged. Discard if a leak is detected.
After opening the vial, the drug should be used immediately! Any unused solution should be disposed of in accordance with local requirements.
Application features
Pregnant women
The safety of Albunorm for pregnant women has not been studied in controlled clinical trials. However, experience with clinical use of albumin indicates that no harmful effects on the course of pregnancy or on the fetus and newborn should be expected.
Studies of the effect of the drug Albunorm on reproductive function in animals have not been conducted, since human albumin is a normal component of human blood plasma.
Children
Data on the use of the drug in children are limited. The drug should be prescribed only when the benefits clearly outweigh the potential risks.
Drivers
No effect on the ability to drive and use machines was observed.
Overdose
Hypervolemia may occur if the dose and rate of administration are too high. At the first clinical signs of cardiovascular overload (headache, shortness of breath, swelling of the jugular veins) or increased blood pressure, with increased central venous pressure and pulmonary edema, the drug should be immediately discontinued and hemodynamic parameters should be carefully monitored.
Side effects
Rarely, minor allergic reactions such as facial flushing (flushing), urticaria, fever, nausea. Such reactions usually disappear quickly when the infusion rate is slowed down or the infusion is stopped. Very rarely, severe reactions such as shock may occur. In case of severe reactions, the infusion should be stopped immediately and appropriate therapy should be initiated.
Interaction
Specific interactions of human albumin with other drugs are not known.
The risk of hypotension is increased when albumin is coadministered with ACE inhibitors in patients receiving plasmapheresis.
Storage conditions
Store at a temperature not exceeding 25 °C. Do not freeze.
Store in the cardboard box to protect from light.
Keep out of reach of children.
Shelf life - 3 years.
After opening the bottle, use the solution immediately.
