Instructions for use Alkodez IS tablets 0.5 g No. 4
Composition
active ingredient: metadoxine;
1 tablet contains 0.5 g of metadoxine;
excipients: microcrystalline cellulose, magnesium stearate, colloidal anhydrous silicon dioxide, croscarmellose sodium.
Dosage form
Pills.
Main physicochemical properties: tablets of white or white with a creamy tint, flat-cylindrical shape, with a bevel and a score; the company's trademark is applied to the surface of one side of the tablet.
Pharmacotherapeutic group
Drugs used in alcohol dependence. ATX code N07B B.
Pharmacological properties
Pharmacodynamics
Anti-alcohol, detoxification, hepatoprotective agent. Activates liver enzymes involved in ethanol metabolism (alcohol dehydrogenase and acetaldehyde dehydrogenase), which helps accelerate the process of removing ethanol and acetaldehyde from the body, reducing their toxic effects. Increases the resistance of hepatocytes to lipid peroxidation products induced by the effects of various toxic agents, in particular ethanol. Prevents the accumulation of fats in hepatocytes, which prevents the formation of fatty infiltration of the liver. Prevents the formation of fibronectin and collagen, which slows down the development of liver cirrhosis.
Activates choline and GABAergic neurotransmitter systems, resulting in improved thinking and short-term memory functions. Prevents the occurrence of motor excitement caused by ethanol. Has a nonspecific antidepressant and anxiolytic effect, reduces craving for alcohol. Reduces the time of withdrawal syndrome, reduces mental and somatic manifestations of hangover syndrome.
Pharmacokinetics
Metadoxine is rapidly absorbed from the digestive tract, has high bioavailability (60-80%). Binding to blood plasma proteins is approximately 50%. Metabolized in the liver to active metabolites - pyridoxine and pyrrolidone carboxylate. The half-life of metadoxine when taken orally or parenterally is 40-60 minutes. 45-50% of metadoxine is excreted in the urine within 24 hours, 35-50% - with feces within 96 hours.
Indication
Reducing the toxic effects of alcohol.
Acute alcohol intoxication (mild and moderate severity).
Alcohol withdrawal syndrome.
Chronic alcoholism.
Comprehensive therapy of liver diseases, especially those of alcoholic etiology.
Contraindication
Hypersensitivity to any of the components of the drug.
Interaction with other medicinal products and other types of interactions
When used together with metadoxine, it reduces the therapeutic efficacy of levodopa by enhancing its decarboxylation.
Application features
Metadoxine reduces the therapeutic effect of levodopa, so it should be used with caution in Parkinson's disease on the background of levodopa therapy.
In cases of severe alcohol intoxication, accompanied by loss of consciousness, uncontrollable vomiting, etc., oral administration of medications is inappropriate.
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Use during pregnancy or breastfeeding
Not used.
Method of administration and doses
The drug is prescribed to adults orally.
To reduce the toxic effects of alcohol: 2 tablets 30-60 minutes before drinking alcohol or 1 tablet 30-60 minutes before drinking alcohol and 1 tablet within 30 minutes after drinking alcohol.
In acute alcohol intoxication of mild and moderate severity, alcohol withdrawal syndrome: 1 tablet 2 times a day 15-30 minutes before meals, the dose can be increased to 3 tablets per day. The course of therapy is 3-7 days, depending on the patient's condition.
In complex therapy of liver diseases and chronic alcoholism: 1 tablet 2 times a day 15-30 minutes before meals. The maximum daily dose is 3 tablets. The course of therapy is at least 90 days.
Children
Should not be used in children due to lack of experience in this age group.
Overdose
No cases of metadoxine overdose have been reported.
Adverse reactions
Allergic reactions.
Expiration date
3 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
4 tablets in a blister, 1 blister in a pack.
Vacation category
Without a prescription.
Producer
Additional Liability Company "INTERCHEM".
Location of the manufacturer and its business address
Ukraine, 65025, Odessa, 21st km. Starokyivska Road, 40-A.
