Instructions Alpha-tocopherol acetate (vitamin E) oral oily solution 300 mg/ml bottle 20 ml
Composition
active ingredient: vitamin E acetate;
1 ml of the drug contains vitamin E acetate, calculated as 100% substance 300 mg;
excipient: sunflower oil.
Dosage form
Oral oily solution.
Main physicochemical properties: transparent oily liquid from light yellow to dark yellow, without rancid odor. A greenish tint is allowed.
Pharmacotherapeutic group
Other simple vitamin preparations. Tocopherol (vitamin E). ATX code A11N A03.
Pharmacological properties
Pharmacodynamics
Vitamin E is an antioxidant that protects various endogenous substances of the body from oxidation. It slows down lipid peroxidation, which is activated in many diseases. It participates in the processes of tissue respiration, heme and protein biosynthesis, fat and carbohydrate metabolism, and cell proliferation. With a deficiency of vitamin E, degenerative changes develop in the muscles, the permeability and fragility of capillaries increase, the epithelium of the seminiferous tubules and testicles degenerates, and degenerative processes are observed in the nervous tissue and hepatocytes. Vitamin E deficiency can cause hemolytic jaundice of newborns, malabsorption syndrome, and steatorrhea.
Pharmacokinetics
The drug is absorbed in the intestine in the presence of fat and bile acids, the absorption mechanism is passive diffusion. It is transported by blood β-lipoproteins, the maximum content in the blood is reached 4 hours after administration. It is excreted in the feces, conjugates and tocopherol acid are excreted in the urine.
Indication
As part of the complex treatment:
muscular dystrophies of various nature and genesis; joint and tendon-muscular contractures (Dupuytren's contracture); spinal cord lesions (amyotrophic lateral sclerosis); systemic connective tissue diseases (rheumatoid arthritis, dermatomyositis, rheumatism and fibrositis); disorders of the functions of the male sex glands and the menstrual cycle, with the threat of termination of pregnancy; peripheral vascular lesions, atherosclerosis of vessels, myocardial dystrophy, hypertension; allergic and ulcerative skin lesions, psoriasis; endocrine diseases of the thyroid gland, diabetes mellitus; periodontal disease; pathologies requiring antioxidant therapy. children - for the treatment of hemolytic jaundice of infants, increased capillary permeability in infants, hypotrophy, rickets, developmental disorders, systemic connective tissue diseases (scleroderma, juvenile rheumatoid arthritis), hypochromic anemia;
Contraindication
Increased individual sensitivity to the components of the drug, severe cardiosclerosis, myocardial infarction, vitamin E hypervitaminosis, thyrotoxicosis.
Interaction with other medicinal products and other types of interactions
Vitamin E cannot be used internally in combination with iron, silver preparations, alkaline agents, and indirect anticoagulants.
Vitamin E facilitates the absorption and assimilation of retinol, preventing the development of vitamin A deficiency.
Vitamin E and its metabolites exhibit antagonistic effects on vitamin K. Vitamin E enhances the effect of steroidal and nonsteroidal anti-inflammatory drugs (diclofenac sodium, ibuprofen, prednisolone, etc.); reduces the toxic effect of cardiac glycosides (digitoxin, digoxin, etc.), vitamins A and D.
Vitamin E may increase the effectiveness of anticonvulsants in patients with epilepsy who have elevated blood concentrations of lipid peroxidation products.
Cholestyramine, colestipol, and mineral oils reduce the absorption of vitamin E.
Application features
It is prescribed with caution in patients with atherosclerosis and an increased risk of thromboembolism.
When using the drug, it is necessary to adhere to the dosage and duration of treatment prescribed by the doctor to prevent overdose and the occurrence of hypervitaminosis E.
With prolonged use of high doses of the drug, it is necessary to monitor blood clotting time.
Ability to influence reaction speed when driving vehicles or other mechanisms
If dizziness or blurred vision occurs, you should refrain from driving or operating other machinery.
Use during pregnancy or breastfeeding
During pregnancy or breastfeeding, the drug should be used as prescribed by a doctor.
Method of administration and doses
Alpha-Tocopherol acetate (vitamin E) is administered orally.
1 ml of solution contains 50 mg of vitamin E (1 ml of solution contains 25 drops from a dropper bottle).
Indication
| Daily dose, mg | Daily dose in drops, solution 300 mg/ml | Daily dose in drops, solution 100 mg/ml | Daily dose in drops, solution 50 mg/ml | Notes | |
| For muscular dystrophies, amyotrophic lateral sclerosis, and other diseases of the neuromuscular system | 50 – 100 mg | 4 – 8 drops | 13 – 25 drops | | Take for 30-60 days, repeating the course after 2-3 months. |
| For disorders of spermatogenesis and potency in men | 8 – 25 drops | | | In combination with hormone therapy, prescribed for 30 days |
| With the threat of miscarriage | 100 –150 mg | 8 – 13 drops | 25 – 37 drops | | Take for 7 – 14 days. |
| In case of abortion and deterioration of intrauterine fetal development | 100 –150 mg | 8 – 13 drops | 25 – 37 drops | | Daily or every other day in the first 2-3 months of pregnancy. |
| For atherosclerosis, myocardial dystrophy, peripheral vascular diseases | 100 mg | 8 drops | 25 drops | | The course of treatment is 20-40 days with a possible repetition of treatment after 3-6 months. |
| In the treatment of cardiovascular diseases | 50 –100 mg | 4 – 8 drops | 13 – 25 drops | | Take 1-2 times a day. The course of treatment is 1-3 weeks. |
| For dermatological diseases | 50 –100 mg | 4 –8 drops | 13 –25 drops | | The course of treatment is 20 – 40 days. |
| For hemolytic jaundice of infants, increased capillary permeability in infants, hypotrophy, rickets, developmental disorders, systemic connective tissue diseases (scleroderma, juvenile rheumatoid arthritis), hypochromic anemia. | 5 – 10 mg | | 1 – 2 drops | 2 – 5 drops | The duration of the treatment course is determined by the doctor individually. |
Children.
The drug can be used in children from birth only as prescribed and under the supervision of a doctor.
Overdose
When used in recommended doses, no adverse reactions occur. Taking high doses of vitamin E (400-800 mg per day for a long time) may cause visual disturbances, diarrhea, dizziness, headache, nausea or abdominal cramps, and extreme fatigue or weakness.
Very high doses (more than 800 mg per day for a long time) may lead to an increased risk of bleeding in patients with vitamin K deficiency; impaired metabolism of thyroid hormones and an increased risk of thrombophlebitis and thromboembolism in susceptible patients, increased creatine kinase activity, increased serum cholesterol and triglyceride concentrations, and increased urinary estrogen and androgen levels.
Treatment: drug withdrawal, symptomatic therapy.
Adverse reactions
Allergic reactions (including itching, skin hyperemia). With prolonged use of large doses of vitamin E, decreased blood clotting, bleeding in the gastrointestinal tract, liver enlargement, creatinineuria, fatigue, weakness, headache, nausea, dizziness, blurred vision are possible.
Expiration date
2 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
20 ml in a glass bottle with a dropper stopper and a screw cap. 1 bottle in a cardboard box.
Vacation category
Without a prescription.
Producer
Technolog PJSC.
Location of the manufacturer and its business address.
Ukraine, 20300, Cherkasy region, Uman city, Stara Prorizna Street, building 8.
