Instructions Antral film-coated tablets 0.2 g blister No. 30
Composition
active ingredient: 1 tablet contains antral in terms of dry matter 100 mg (0.1 g) or 200 mg (0.2 g);
excipients: heavy magnesium carbonate, potato starch, crospovidone, microcrystalline cellulose, povidone, polysorbate, colloidal anhydrous silicon dioxide, calcium stearate, Opadry II 85 G18490 white, Opadry II 85 G25557 red.
Dosage form
Film-coated tablets.
Main physicochemical properties: round tablets with a biconvex surface, coated with a dark red film coating.
Pharmacotherapeutic group
Hepatoprotective drugs. ATC code A05B A.
Pharmacological properties
Pharmacodynamics.
Antral belongs to the group of hepatoprotective drugs. It is effective in the treatment of acute and chronic hepatitis of various genesis, liver cirrhosis, helps reduce asthenovegetative disorders, improves appetite, sleep, reduces dyspeptic phenomena. When used in courses, the drug normalizes the content of bilirubin, γ-globulins, cholesterol in the blood, prothrombin index, transaminase activity (ALT and AST) and alkaline phosphatase. Antral is characterized by prolonged anti-inflammatory, analgesic action. According to the results of preclinical studies, it was found that Antral in conditions of acute, subacute and chronic liver damage by various xenobiotics and their combinations helps to weaken the effects of hepatotoxins, activate reparative processes in hepatocytes and practically normalize the indicators of the structural and functional state of the liver. The drug inhibits lipid peroxidation processes in the blood and tissues, supports the activity of the body's antioxidant systems, stabilizes the structure of the liver and hepatocyte membranes. As a relatively harmless pharmacological agent, Antral does not disrupt the functions of organs and body systems, it has no cumulative properties, immunotoxic, locally irritating, allergenic, ulcerogenic, embryotoxic, teratogenic effects.
Pharmacokinetics.
The maximum accumulation of the drug in the blood is observed after 3-4 hours, the half-life is 4-5 hours. The drug is excreted in the urine and feces.
Indication
Antral is indicated for adults and children for the treatment of: acute and chronic hepatitis of various genesis (viral, alcoholic, medicinal, toxic); fatty dystrophy and cirrhosis of the liver; inflammatory diseases of the gallbladder, spleen, pancreas; postcholecystectomy syndrome (after removal of the gallbladder). For the prevention of liver diseases due to the negative effects of toxins of various etiologies: alimentary toxins, medicines, chemotherapy, radiation therapy.
Contraindication
Individual hypersensitivity to the components of the drug.
Impaired renal excretory function.
Interaction with other medicinal products and other types of interactions
Antral is compatible with antibacterial, detoxifying, choleretic, and vitamin drugs, which allows it to be included in treatment therapy complexes. When used simultaneously in patients with liver cirrhosis, Antral does not affect the activity of steroid and cytostatic drugs; a reduction (up to 50-70%) of the previously used dose of steroids is allowed without further reduction in the effectiveness of treatment.
Application features
It is recommended to take Antral 20-30 minutes after a meal, with sufficient water or milk.
Use during pregnancy or breastfeeding
Due to limited experience with the drug, it is not recommended to prescribe it during pregnancy or breastfeeding.
Ability to influence reaction speed when driving vehicles or other mechanisms
There is no data on the effects, but drivers and operators of complex mechanisms should consider the possibility of dizziness.
Method of administration and doses
Antral is administered orally after meals 3 times a day:
– adults and children over 10 years old – 200 mg per dose; for liver cirrhosis: in the first week of treatment – 400 mg per dose, then for 2-3 weeks – 200 mg per dose;
– children aged 4-10 years (including those with liver cirrhosis) – 100 mg per dose.
The duration of treatment depends on the nature and severity of the disease. The average course of treatment is 3-4 weeks. The course of treatment should be repeated after 3-4 weeks.
Children
The drug should not be used in children under 4 years of age.
Overdose
In case of overdose, adverse reactions may occur and intensify.
In case of accidental ingestion of large doses of the drug, the stomach should be washed and (if necessary) symptomatic treatment should be carried out.
Adverse reactions
The drug is generally well tolerated by patients. In rare cases, weakness, dizziness, dyspeptic phenomena, nausea, abdominal pain, diarrhea may occur when using Antral, which resolve after discontinuation of the drug.
Allergic reactions, including skin rashes, urticaria, angioedema, redness and itching of the skin.
Expiration date
Do not use the drug after the expiration date indicated on the package.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
10 tablets in a blister. 3 blisters in a pack.
Vacation category
Without a prescription.
Producer
JSC "Farmak".
Location of the manufacturer and its business address
Ukraine, 04080, Kyiv, Kyrylivska St., 74.
