AstraCe powder for oral solution is indicated for the treatment of acute and chronic diseases of the bronchopulmonary system that require reducing the viscosity of sputum, improving its discharge and expectoration. \
Composition
Active ingredient: acetylcysteine;
1 sachet contains acetylcysteine in terms of 100% substance 200 mg;
Excipients: ascorbic acid, saccharin, sucrose, "Orange" flavoring.
Contraindication
Hypersensitivity to acetylcysteine or to other components of the drug. Gastric and duodenal ulcer in the acute stage, hemoptysis, pulmonary hemorrhage, severe exacerbation of bronchial asthma.
Method of application
Adults and children over 14 years of age should be prescribed 400-600 mg of acetylcysteine per day, divided into 1-3 doses.
Children from 6 to 14 years old should be prescribed 400-600 mg per day, divided into 2-3 doses.
Children from 2 to 6 years old should be prescribed 200-400 mg per day, divided into 2 doses.
The drug is recommended to be taken after meals. Dissolve the contents of the sachet in ½ cup of water, juice or cold tea. After preparing the solution, it should be drunk as soon as possible.
In some cases, due to the presence of a stabilizer - ascorbic acid - in the composition of the drug, the prepared solution can be left for about 2 hours before use. Additional fluid intake enhances the mucolytic effect of the drug.
The duration of treatment for chronic diseases is determined by the doctor depending on the nature and course of the disease. In acute uncomplicated diseases, acetylcysteine should be used for 4-5 days.
Application features
Pregnant women
During pregnancy or breastfeeding, the use of acetylcysteine is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or child.
Children
The drug should be used in children from 2 years of age.
Drivers
No effect.
Overdose
There is insufficient data on cases of overdose with oral administration of acetylcysteine.
Volunteers took 11.6 g of acetylcysteine per day for 3 months without any serious side effects. Oral doses of up to 500 mg of acetylcysteine per kg of body weight per day were tolerated without any symptoms of intoxication.
Symptoms: nausea, vomiting, diarrhea. There is a risk of hypersecretion in children.
Treatment: therapy is symptomatic.
Side effects
From the cardiovascular system: infrequently - tachycardia, arterial hypotension.
From the nervous system: infrequently - headache.
Skin: infrequently - allergic reactions (itching, urticaria, rash, eczema, rash, angioedema).
On the part of the organs of hearing: infrequently - ringing in the ears.
On the part of the respiratory system: rarely - dyspnea, bronchospasm (mainly in patients with bronchial hyperreactivity associated with bronchial asthma), rhinorrhea.
Gastrointestinal tract: infrequently - heartburn, dyspepsia, stomatitis, abdominal pain, nausea, vomiting, diarrhea, bad breath.
General disorders: infrequently - fever.
Interaction
Interaction studies were conducted only with the participation of adults.
The use of antitussives with acetylcysteine may increase sputum congestion due to a decrease in the cough reflex.
When used simultaneously with antibiotics such as tetracycline (except doxycycline), ampicillin, amphotericin B, cephalosporins, aminoglycosides, their interaction with the thiol group of acetylcysteine is possible, which leads to a decrease in the activity of both drugs. Therefore, the interval between the use of these drugs should be at least 2 hours. This does not apply to cefixime and loracarbef.
Activated charcoal reduces the effectiveness of acetylcysteine.
It is not recommended to dissolve acetylcysteine in the same glass of water with other drugs.
Storage conditions
Store in the original packaging at a temperature not exceeding 25ºС.
Keep out of reach of children.
Shelf life - 3 years.
