Pharmacological properties
Magnesium is an important element for metabolism in the body. It is necessary for many energy processes, participates in the metabolism of proteins, fats, carbohydrates, nucleic acids and in the process of neuromuscular excitation.
Numerous functions of energy generation or expenditure (e.g. oxidative phosphorylation or ion pump, muscle contraction) depend on magnesium, and in case of its deficiency can be partially or completely disrupted.
Magnesium activates glycolytic enzymes, cellular oxidation enzymes, nucleic acid synthesis enzymes, it also plays an important role in the processes of myocardial contraction, is a stabilizer of fibrinogen and platelets. It is known that magnesium deficiency is one of the causes of the development of hypertension, vasospasm, neoplastic diseases and urolithiasis. In stressful situations, an increased amount of free ionized magnesium is excreted, therefore an additional amount of magnesium helps to increase resistance to stress. Magnesium plays a leading role in the processes of neuromuscular excitation, acting as an antagonist of calcium ions.
The total amount of magnesium in the body of an adult is about 20-30 g. Of this amount, about 50% is contained in the bones, 45% in the cells, and only 5% of the total amount can be determined in the blood plasma.
Intracellular magnesium concentration varies from 10 to 60 mmol/L, the normal value of magnesium concentration in blood plasma is from 0.7 to 1.1 mmol/L. In blood plasma, approximately ⅔ of magnesium ions are in dissolved form and about 1/3 is bound to proteins.
When taken internally, magnesium is absorbed depending on the initial magnesium content in the body. With a magnesium deficiency in the body, a larger amount is absorbed, and with magnesium saturation - less. The ratio of the development corresponds to the homeostatically regulated kinetics of development, characteristic of physiologically active substances.
With a balanced magnesium balance and normal kidney function, even with high doses of magnesium, its accumulation does not exceed the normal limit.
After absorption in the intestine, magnesium is mainly excreted by the kidneys. Unabsorbed magnesium is excreted in the feces.
Indication
Treatment and prevention of magnesium deficiency in the body in cases where it is the cause of muscle disorders (neuromuscular disorders, cramps), with chronic physical and mental fatigue, irritability, myalgia, with intense physical and mental stress, during pregnancy. hypomagnesemia resulting from prolonged smoking and alcohol abuse, prolonged use of laxatives, contraceptives, certain diuretics or as a result of osmotic diuresis in patients with diabetes mellitus with persistent hyperglycemia.
Application
The dose of Biolectra Magnesium Forte depends on the degree of magnesium deficiency in the body. The average daily dose is 1-2 effervescent tablets (243-486 mg of magnesium ions = 10-20 mmol).
Children over 6 years of age are prescribed 1 effervescent tablet once a day.
Adolescents and adults are prescribed 1 effervescent tablet 1-2 times a day.
In case of severe magnesium deficiency, the doctor may prescribe Biolectra Magnesium Forte in higher doses.
The tablet must be dissolved in a glass of water and the resulting solution must be drunk.
The duration of treatment depends on the underlying causes of magnesium deficiency.
Long-term use of magnesium in high doses should be under the supervision of a doctor.
Contraindication
Hypersensitivity to the components of the drug. The drug is not recommended for use in cases of impaired renal function and conduction disorders in the heart (high-degree AV block), which can lead to bradycardia. It is necessary to check whether there are any disorders of mineral and electrolyte metabolism (hypermagnesemia, hyperkalemia). The drug Biolectra Magnesium Forte is contraindicated in myasthenia gravis, exicosis and calcium-magnesium-phosphate-ammonium diathesis.
Side effects
At higher doses, mild diarrhea is possible, which is not considered dangerous and disappears after reducing the dose. With prolonged use of the drug Biolectra Magnesium Forte in high doses, fatigue may occur. In this case, the doctor must, based on clinical and laboratory studies, make a decision on the appropriateness of further use of magnesium.
Special instructions
1 effervescent tablet contains 7.35 mmol (169 mg) of sodium. This should be taken into account by patients on a low-sodium/salt diet.
1 effervescent tablet contains 3.48 mmol (136 mg) of potassium. This should be taken into account in patients with impaired renal function, as well as in those on a low-potassium diet.
Use during pregnancy and breastfeeding. There are no risks of using the drug during pregnancy and breastfeeding.
Children: The drug is not recommended for use in children under 6 years of age.
The ability to influence the reaction speed when driving vehicles or working with other mechanisms. Does not affect.
Interactions
With simultaneous use of drugs containing aluminum (e.g. antacids), the absorption of aluminum may increase.
Enhances the effect of antiarrhythmic and antihypertensive drugs, reduces the degree of magnesium deficiency and the risk of associated complications when taking diuretics, aminoglycosides, cisplatin, cyclosporine, amphotericin, methotrexate, and laxatives.
Overdose
When using magnesium salts orally, hypermagnesemia occurs only in renal failure. Magnesium salts are contraindicated in these patients.
Symptoms of intoxication. High concentrations of magnesium cause skeletal muscle relaxation (magnesium concentrations in blood plasma 5.5 mmol/l). Magnesium ion concentrations of 10-20 mmol/l prolong the conduction period in the heart, and even higher concentrations lead to cardiac arrest in diastole.
Treatment for intoxication. Intravenous administration of calcium instantly leads to the disappearance of the described symptoms, since there is antagonism between calcium and magnesium ions.
Storage conditions
In the original packaging at a temperature not exceeding 25 °C.
Exclusive distributor: PrJSC "Naturpharm", 30a Lisova St., Kyiv, Pushcha-Vodytsia, 04075; phone: (044) 401-81-03.
Supplier: Alpen Pharma AG (Switzerland).
