Instructions for Biotin-KV tablets 10 mg No. 30
Composition
active ingredient: biotin;
1 tablet contains 5 mg or 10 mg of biotin;
Excipients: lactose monohydrate; microcrystalline cellulose; povidone; crospovidone; magnesium stearate.
Dosage form
Pills.
Main physicochemical properties:
5 mg tablets: round tablets, with a biconvex surface, white or almost white in color;
10 mg tablets: round tablets, with a biconvex surface, with a score, white or almost white in color.
Pharmacotherapeutic group
Vitamins. Other vitamin preparations. Biotin.
ATX code A11N A05.
Pharmacological properties
Pharmacodynamics.
Biotin is a vital substance for cell development and growth. As a coenzyme, it plays an important role in gluconeogenesis, lipogenesis, propionate biotransformation, fatty acid synthesis and leucine breakdown. Biotin deficiency can occur with unbalanced nutrition, long-term diets and consumption of raw egg protein; in addition, with biotin-associated multiple carboxylase deficiency, the need for biotin due to a genetic defect is increased. Deficiency is manifested by a reaction on the skin and its appendages, and the consequences can be specific mental symptoms and intestinal disorders during parenteral nutrition, in malabsorption syndrome, after small bowel resection, in patients on hemodialysis.
Biotin (vitamin H, vitamin B7) is a water-soluble vitamin of group B. In the body, biotin plays an important role in the metabolism of carbohydrates, fats and proteins and is vital for normal cell growth and development. When ingested, biotin acts as a coenzyme of carboxylases, has an insulin-like effect and participates in the process of gluconeogenesis (due to participation in the synthesis of glucokinase), in connection with which it helps stabilize blood sugar levels, improves the function of the nervous system. Biotin is a synergist of other B vitamins, folic acid, pantothenic acid, cyanocobalamin. There is evidence of biotin's participation in the synthesis of purine nucleotides. Biotin is also a source of sulfur, which participates in the synthesis of protein - collagen and, thus, has a positive effect on the structure of the skin and its appendages (hair, nails).
Pharmacokinetics.
Absorption of free biotin begins in the upper part of the small intestine. Here, the biotin molecule penetrates the intestinal wall unchanged. Absorption occurs mainly by diffusion.
The degree of binding of biotin to blood plasma proteins is 80%.
The concentration of free or only weakly bound biotin in the blood is usually from 200 to 1200 μg/l. Biotin is excreted in the urine (from 6 to 50 μg per day) and feces. Biotin is excreted unchanged (about 50%) and as biologically inactive metabolites. The half-life depends on the dose administered and is almost 26 hours after oral administration of 100 μg per kilogram of body weight. In patients with biotinidase deficiency, the half-life after the same dose is reduced to 10–14 hours.
Biotin enters the human body from food and is also synthesized by intestinal microflora. Biotin, which is widespread in the diet, is mostly bound to protein and occurs in the form of biocytin (food of animal origin), which is rapidly reabsorbed after hydrolysis in the small intestine. In plants, biotin is partially present in free form.
Indication
For the treatment of diseases caused by biotin deficiency: skin, nail, hair diseases.
For the treatment of genetically determined biotin-associated enzymopathies (multiple carboxylase deficiency).
Contraindication
Hypersensitivity to biotin or to other components of the drug.
Interaction with other medicinal products and other types of interactions
When using biotin with anticonvulsants, a decrease in the concentration of biotin in the blood plasma is possible due to increased excretion in the urine.
Valproic acid reduces biotinidase activity, reducing mitochondrial function in the liver.
Pantothenic acid in large doses competes with biotin, so their simultaneous use should be avoided.
Application features
Raw egg white contains the protein avidin, which interacts with biotin, so you should avoid taking them together.
Eating a large amount of raw eggs for 2–3 weeks can cause biotin deficiency.
Impact on clinical laboratory tests.
When interpreting laboratory test results, the possible influence of biotin should be considered, especially if there is a lack of agreement with the clinical picture (e.g., thyroid test results mimicking Graves' disease in asymptomatic patients taking biotin, or false-negative troponin test results in patients with myocardial infarction taking biotin). When interference is suspected, alternative tests that are immune to biotin interference should be used.
When ordering laboratory tests, patients taking biotin should consult with laboratory personnel.
The medicine contains lactose, therefore, if you have been told by your doctor that you have an intolerance to some sugars, consult your doctor before taking it.
Use during pregnancy or breastfeeding
There is no experience with the use of the drug during pregnancy and breastfeeding.
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Method of administration and doses
Take the tablets before meals, without chewing, with sufficient liquid.
When treating biotin deficiency (diseases of nails, hair, skin): the recommended dose for adults is 1 tablet of 5 mg per day;
For the treatment of genetically determined enzymopathies associated with biotin (multiple carboxylase deficiency): 1-2 tablets are prescribed (daily dose - up to 20 mg of biotin).
The duration of the treatment course depends on the nature and course of the disease.
Children.
There are no data on use in children.
Overdose
There are currently no reports of biotin overdose.
Side effects
Allergic reactions are possible on the part of the immune system, including hives, chest pain, shortness of breath, and skin rashes.
If any adverse reactions occur, it is recommended to discontinue treatment and consult a doctor.
Expiration date
2 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
10 tablets in a blister; 3 blisters in a pack.
Vacation category
Without a prescription.
Producer
JSC "KYIV VITAMIN FACTORY".
Address
04073, Ukraine, Kyiv, Kopylivska St., 38.
Website: www.vitamin.com.ua
