Blimol solution for infusion is indicated for:
adults:
for short-term treatment of moderate pain syndrome, especially in the postoperative period. for short-term treatment of hyperthermic reactions, when only intravenous administration of the drug is necessary.
Children: for symptomatic treatment of pain and hyperthermia in postoperative patients.
Composition
active ingredient: paracetamol;
1 ml of solution contains paracetamol - 10 mg;
Excipients: propylene glycol; citric acid monohydrate, sodium metabisulfite (E 223), sodium phosphate dihydrate; sodium chloride, water for injections.
Contraindication
hypersensitivity to paracetamol and other components of the drug; severe hepatocellular insufficiency; severe liver and/or kidney dysfunction; congenital hyperbilirubinemia; glucose-6-phosphate dehydrogenase deficiency; alcoholism; blood diseases; Gilbert's syndrome; severe anemia; leukopenia.
Method of application
Blimol is used for rapid relief of pain and/or hyperthermia when only intravenous administration of the drug is necessary.
The duration of the infusion should be 15 minutes.
In patients with renal insufficiency (creatinine clearance <30 ml/min), the interval between doses should be increased to 6 hours. The duration of treatment should not exceed 48 hours.
For adult patients with hepatocellular insufficiency, chronic alcoholism, chronic nutritional disorders (low hepatic glutathione reserves), dehydration, the maximum daily dose should not exceed 3 g.
Application features
Pregnant women
Not recommended.
Children
Do not use in children under 1 year of age and weighing less than 10 kg.
Use in children aged 1 year and over with a body weight of more than 10 kg only for symptomatic treatment of pain and hyperthermia in postoperative patients.
Drivers
No effect.
Overdose
The risk of toxic effects of the drug increases in the elderly, children, patients with liver failure, in cases of chronic alcoholism, in the presence of alimentary dystrophy and in people with reduced enzymatic activity. In these cases, overdose can be fatal.
Symptoms appear within the first 24 hours and are manifested by nausea, vomiting, anorexia, pallor, and abdominal pain.
Overdose in adults can occur with a single administration of 7.5 g or more, in children - 140 mg / kg of body weight. In this case, liver cytolysis, liver failure, metabolic acidosis, encephalopathy develop, which can lead to coma and death of the patient. Within 12-48 hours, the level of hepatic transaminases (AST, ALT), lactate dehydrogenase, bilirubin increases and the level of prothrombin decreases. Clinical symptoms of liver damage appear after two days and reach a maximum after 4-6 days.
Treatment: immediate hospitalization of the patient. Administration of SH-group donors and precursors of glutathione-methionine synthesis after 8-9 hours. After overdose and N-acetylcysteine - after 12.00. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.
Side effects
Blood and lymphatic system disorders: thrombocytopenia, leukopenia, neutropenia, agranulocytosis, anemia, sulfhemoglobinemia and methemoglobinemia (cyanosis, shortness of breath, heart pain), hemolytic anemia, bruising or bleeding. Immune system disorders: angioedema. Gastrointestinal tract: nausea, epigastric pain. Skin and subcutaneous tissue disorders: erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome). Cardiac disorders: shortness of breath, hypotension, tachycardia. Metabolism disorders: hypoglycemia, up to hypoglycemic coma. General: malaise, weakness, pain and burning at the injection site, skin redness, hypersensitivity reactions, anaphylactic shock.
Interaction
Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) can contribute to the development of severe intoxications even with a small overdose.
Paracetamol reduces the effectiveness of diuretics.
Paracetamol should not be used simultaneously with alcohol.
Storage conditions
Store in a place protected from light at a temperature not exceeding 25 °C.
Keep out of reach of children.
Shelf life - 2 years.
