Caffeine-sodium benzoate-Darnitsa solution for injection 100 mg/ml ampoule 1 ml No. 10

Pharmacological properties

It is used mainly as a stimulant of the central nervous system. Caffeine enhances and regulates the processes of excitation in the cerebral cortex, enhances positive reflexes, increases motor activity. This effect is transformed into an increase in mental and physical performance, a decrease in fatigue and drowsiness. The effect of the drug largely depends on the type of higher nervous activity. In addition, the observed effects depend on the dose, and the use of caffeine in high doses can lead to neuronal depletion. The drug weakens the effect of hypnotics and narcotics, increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, increases heart rate and myocardial contractility. The hypertensive effect is observed only in shock and collaptoid states. Diuresis under the influence of caffeine increases slightly (mainly due to a decrease in the reabsorption of electrolytes in the renal tubules).

The mechanism of action of the drug is due to the inhibition of the enzyme phosphodiesterase by caffeine, which leads to the accumulation of cAMP inside cells. The latter enhances glycogenolysis, stimulates metabolism in organs and tissues, including the central nervous system and muscles. An important link in the mechanism of the stimulating effect of the drug is the binding of caffeine to purine receptors in the brain.

Indication

Infectious and other diseases accompanied by depression of the central nervous system and cardiovascular system (acute heart failure), respiratory depression, asphyxia, poisoning with drugs, other poisons that depress the CNS, asthenic syndrome, spasms of cerebral vessels. The drug is prescribed to increase mental and physical performance, eliminate drowsiness. In children, it is used for enuresis.

Application

Assign s / k. The dose of the drug is set individually, the frequency of administration is no more than 2-3 times a day. A single dose for adults is usually 1 ml of 10% or 20% solution, children are prescribed (depending on age) 0.25-0.1 ml of 10% solution. Higher doses for adults: single - 0.4 g, daily - 1 g.

Contraindication

Increased excitability, insomnia, severe hypertension, atherosclerosis, organic diseases of the cardiovascular system, old age, glaucoma.

Side effects

Insomnia, anxiety, nausea, vomiting, tachycardia (especially with prolonged use) are possible.

Overdose

In case of poisoning with the drug, oxygen therapy is performed, and in case of convulsions, diazepam is prescribed.

Storage conditions

At room temperature.