Carboplatin Medak concentrate for solution for infusion 450 mg bottle 45 ml No. 1

Carboplatin Medak concentrate for solution for infusion is indicated for epithelial ovarian cancer and small cell lung cancer as monotherapy or in combination with other antineoplastic agents.

Composition

Active ingredient: carboplatin;

1 ml of concentrate contains 10 mg of carboplatin;

Excipients: water for injections.

Contraindication

Method of application

The drug is intended for intravenous use only.

In previously untreated adult patients with normal renal function, carboplatin injections should be administered at a dose of 400 mg/m2 over the body by short intravenous infusions (duration 15-60 min).

Application features

Pregnant women

Contraindicated.

Children

The drug should not be used in children.

Drivers

It can cause nausea, vomiting, visual impairment and ototoxicity, therefore it is not recommended to drive vehicles and operate machinery during treatment.

Overdose

In case of overdose, severe bone marrow depression, liver and kidney dysfunction, and vision loss can be expected. Treatment is symptomatic and supportive. There is no specific antidote for carboplatin injection. Blood transfusions and bone marrow transplantation may help reduce the severity of hematologic side effects.

Side effects

Secondary acute malignant neoplasms after cytostatic combination therapy with carboplatin.

Acute promyelocytic leukemia 6 years after carboplatin monotherapy and prior radiotherapy.

Alopecia, fever, inflammation of the mucous membrane, asthenia, malaise, taste perversion, anxiety, weight loss, tachycardia.

In some cases - hemolytic-uremic syndrome.

Isolated cases of cardiovascular diseases (heart failure, embolism) and cerebrovascular disorders.

Cases of high blood pressure.

Interaction

Concomitant use with yellow fever vaccine is contraindicated - risk of generalized vaccine-induced disease, which can be fatal.

Concomitant use is not recommended with live attenuated vaccines (except yellow fever vaccine) - risk of systemic disease, which can be fatal. With inactivated vaccine (poliomyelitis). With phenytoin, fosphenytoin.

Storage conditions

Store in the original package to protect from light.

Store at a temperature not exceeding 25 °C. Do not freeze.

Keep out of reach of children.

Shelf life - 18 months.