Cardipril 10 capsules are indicated for:
Treatment of arterial hypertension. Treatment of kidney disease. Treatment of heart failure accompanied by clinical manifestations.
Composition
Active ingredient: ramipril;
1 capsule contains ramipril 2.5 mg or 5 mg or 10 mg;
Excipient: pregelatinized starch.
Contraindication
The drug is not recommended for use in children (under 18 years of age).
Hypersensitivity to the active substance or to any of the excipients included in the formulation or to other ACE (angiotensin-converting enzyme) inhibitors (see section "Composition"); history of angioedema (hereditary, idiopathic or previously suffered against the background of the use of ACE inhibitors or angiotensin II receptor antagonists); significant renal artery stenosis (bilateral stenosis or stenosis of the artery to a solitary kidney); hypotensive or hemodynamically unstable conditions, systemic lupus erythematosus, scleroderma (increased risk of neutropenia or agranulocytosis); suppression of bone marrow hematopoiesis; hyperkalemia, kidney transplantation, renal failure, hyponatremia (risk of dehydration, hypotension, renal failure), hepatic failure, primary hyperaldosteronism.
Pregnant women or women planning to become pregnant (see section “Use during pregnancy and breastfeeding”).
Should not be used with aliskiren-containing drugs in patients with diabetes mellitus or moderate or severe renal impairment (GFR < 60 mL/min).
The use of ramipril or other ACE inhibitors in combination with extracorporeal therapy methods that may cause blood to come into contact with negatively charged surfaces should be avoided, as there is a risk of severe anaphylactoid reactions, which can sometimes lead to severe anaphylactic shock. Therefore, dialysis or hemofiltration using polyacrylonitrile, sodium-2-methylsulfonate membranes with high ultrafiltration activity (e.g., "AN 69") and LDL (low-density lipoprotein) apheresis using dextran sulfate should not be performed while taking ramipril.
Method of application
Drug for oral use.
It is recommended to take the drug at the same time every day. The drug can be taken before, during, or after meals, as food intake does not affect the bioavailability of the drug. The capsules should be swallowed whole with water. They should not be chewed or crushed.
Application features
Pregnant women
The drug is contraindicated for use in pregnant women or women planning to become pregnant. If pregnancy is detected during therapy, the drug should be discontinued immediately and, if necessary, replaced with another drug approved for use in pregnant women (see section "Contraindications").
Children
The drug is not recommended for use in children (under 18 years of age) as there is insufficient data on the efficacy and safety of this drug in such patients.
Drivers
Some side effects (e.g. symptoms of low blood pressure, such as dizziness) may impair the patient's ability to concentrate and reduce the speed of their reactions, which is risky in situations where these qualities are particularly important (e.g. when driving vehicles or operating other mechanisms).
This is usually possible at the beginning of treatment or when switching from other drugs to treatment with the drug. After taking the first dose or a subsequent increase in dose, it is advisable not to drive or operate other machinery for several hours.
Overdose
Symptoms: Overdose may cause excessive peripheral vasodilation (with severe hypotension, shock), bradycardia, electrolyte imbalance and renal failure.
Treatment. The patient should be carefully monitored and symptomatic and supportive therapy should be administered. The proposed treatment measures include primary detoxification (gastric lavage, administration of adsorbents), as well as measures aimed at restoring stable hemodynamics, including the administration of alpha-1-adrenoceptor agonists or angiotensin II (angiotensinamide). Ramiprilat, the active metabolite of ramipril, is poorly removed from the systemic circulation by hemodialysis.
Side effects
Because ramipril is an antihypertensive agent, many of its adverse effects are secondary to its ability to lower blood pressure, resulting in adrenergic feedback or organ hypoperfusion. Numerous other effects (e.g., effects on electrolyte balance, certain anaphylactoid reactions, or mucosal inflammatory reactions) are due to ACE inhibition or other pharmacological effects of this class of drugs. Serious adverse reactions include angioedema, persistent cough, hyperkalemia, hepatic or renal dysfunction, pancreatitis, severe skin reactions, and neutropenia/agranulocytosis.
Interaction
Alcohol: Increased vasodilation. Ramipril may enhance the effects of alcohol.
Specific hyposensitization. ACE inhibition increases the likelihood and severity of anaphylactic and anaphylactoid reactions to insect venom. It is believed that this effect may also be observed for other allergens.
Storage conditions
Keep out of reach of children. Store in the original packaging at a temperature not exceeding 30 °C.
Shelf life - 3 years.
