Cefodox tablets are used for infections caused by cefpodoxime-sensitive pathogens:
ENT organs (including sinusitis, tonsillitis, pharyngitis); for the treatment of tonsillitis and pharyngitis, "Cefodox" is prescribed for chronic or recurrent infection, as well as in cases of known or suspected insensitivity of the pathogen to widely used antibiotics; respiratory tract (including acute bronchitis, relapses or exacerbations of chronic bronchitis, bacterial pneumonia); uncomplicated infections of the upper and lower urinary tract (including acute pyelonephritis and cystitis); skin and soft tissues (abscesses, cellulitis, infected wounds, furuncles, folliculitis, paronychia, carbuncles and ulcers).
Composition
The active substance is cefpodoxime (one tablet contains cefpodoxime (in the form of proxetil) 200 mg).
Excipients: silicified microcrystalline cellulose, croscarmellose sodium, sodium starch glycolate (type A), sodium lauryl sulfate, colloidal anhydrous silicon dioxide, magnesium stearate, Opadry OY-L white 28900 (lactose, monohydrate; titanium dioxide (E 171); polyethylene glycol; hydroxypropylmethylcellulose), iron oxide yellow (E172), polyethylene glycol 6000.
Contraindication
Hypersensitivity to cephalosporin, penicillin or any other component of the drug.
Method of application
Tablets should be taken orally with food to enhance absorption.
For adults and children over 12 years of age with normal kidney function, the following doses are recommended:
ENT organs: sinusitis - 400 mg (200 mg 2 times a day); other infections (including tonsillitis, pharyngitis) - 200 mg (100 mg 2 times a day); respiratory tract infections (including acute bronchitis, relapses or exacerbations of chronic bronchitis, bacterial pneumonia) - 200-400 mg (depending on the sensitivity of the pathogen) (100-200 mg 2 times a day); uncomplicated urinary tract infections: upper (acute pyelonephritis) - 400 mg (200 mg 2 times a day); lower (cystitis) - 200 mg (100 mg 2 times a day); skin and soft tissue infections (abscesses, cellulitis, infected wounds, furuncles, folliculitis, paronychia, carbuncles and ulcers) - 400 mg (200 mg 2 times a day); uncomplicated gonococcal urethritis - 200 mg (single dose).
The duration of treatment depends on the severity of the disease and is determined individually.
Application features
Pregnant women
There are no data on the safety of cefpodoxime during pregnancy. Therefore, the drug should be used during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus, especially in the first months of pregnancy.
Cefpodoxime is excreted in breast milk. If necessary, use of the drug should stop breastfeeding.
Children
Cefodox tablets are prescribed to children over the age of 12.
Drivers
Dizziness may occur when using cefpodoxime, which may affect the ability to drive or operate complex machinery.
Overdose
Symptoms: nausea, vomiting, abdominal pain, diarrhea. In patients with renal failure, encephalopathy may occur in case of overdose. Cases of encephalopathy are usually reversible at low levels of cefpodoxime in the blood plasma.
Treatment: Hemodialysis, peritoneal dialysis. Symptomatic therapy.
Side effects
General disorders: fungal infections, malaise, fatigue, asthenia, fever, chest pain (pain may radiate to the lower back), back pain, chills, generalized pain, abscess, allergic reactions, facial swelling, bacterial infections, localized swelling, localized pain, growth of non-susceptible microorganisms.
Cardiovascular system: congestive heart failure, migraine, palpitations, vasodilation, hematomas, arterial hypertension or hypotension.
Gastrointestinal tract: diarrhea, abdominal pain, feeling of fullness in the stomach, nausea, tenesmus, bloating, vomiting, dyspepsia, decreased appetite, constipation, anorexia, candidal stomatitis, toothache, belching, gastritis, dry mouth, thirst, mouth ulcers, pseudomembranous colitis.
Diarrhea with blood may be a symptom of enterocolitis. In case of severe or persistent diarrhea occurring during or after treatment, pseudomembranous colitis should be suspected.
On the part of the blood: hemolytic anemia, decreased hemoglobin, decreased hematocrit, eosinophilia, leukocytosis, leukopenia, lymphocytosis, lymphopenia, agranulocytosis, thrombocytosis, neutropenia, thrombocytopenia, positive Coombs test, increased thrombin and prothrombin time.
Metabolic disorders: dehydration, gout, peripheral edema, weight gain.
Musculoskeletal system: myalgia.
Nervous system: cephalalgia, vertigo, dizziness, unsteadiness of gait, headache, hemorrhages, anxiety, nervousness, neurosis, insomnia, sleep disorders, changes in dreams (unusual dreams, nightmares), paresthesia, confusion.
From the respiratory system: bronchial asthma, cough, nosebleeds, rhinitis, wheezing, sneezing, bronchospasm, shortness of breath, pleural effusion, pneumonia.
From the sensory organs: change or loss of taste, eye irritation, ringing/tinnitus in the ears.
On the part of the immune system: hypersensitivity reactions of all degrees of severity, anaphylactic reactions, angioedema, purpura, serum sickness, joint pain, fever were noted.
From the genitourinary system: hematuria, urinary tract infections, metrorrhagia, vaginal candidiasis, dysuria, frequent urination, proteinuria, increased urea and creatinine in the urine; in isolated cases, impaired renal function, especially with the simultaneous use of cefpodoxime with aminoglycosides and / or strong diuretics.
Storage conditions
Store at a temperature not exceeding 30 °C, out of the reach of children.
Shelf life - 3 years.
