Celanid tablets 0.25 mg No. 30

Name: Celanidum

Pharmacological action:
It acts on the heart similarly to other digitalis glycosides, causes a rapid effect and is not very accumulative (it accumulates little in the body).

Indications for use:
Acute and chronic circulatory failure of stages I, II and III, tachyarrhythmic form of atrial fibrillation (heart rhythm disturbance), paroxysmal tachycardia (heart rhythm disturbance).

Method of application:
It is administered orally in tablets (0.25 g) or drops (0.05% solution), as well as intravenously (0.02% solution for injection). To obtain a quick effect, 0.2-0.4 mg (1-2 ml of 0.02% solution) is administered intravenously 1-2 times a day. It is used starting with 0.25-0.5 mg (1-2 tablets) or 10-25 drops of 0.05% solution 3-4 times a day (daily doses sometimes exceed the higher daily doses provided for by the Pharmacopoeia). After achieving a therapeutic effect (with intravenous administration usually on the 2nd-3rd day, and with oral administration on the 3rd-5th day), the daily dose is reduced to a maintenance dose: 0.4-0.2 mg (2-1 ml of 0.02% solution) intravenously; 0.5-0.25 mg (2-1 tablet) or 40-20-10 drops of 0.05% solution orally. For long-term maintenance therapy, 1/2 tablet is prescribed orally 2 times a day.
Higher doses for adults: orally, single dose - 0.0005 g (0.5 mg), daily dose - 0.001 g (1 mg); intravenously, single dose - 0.0004 g (0.4 mg), daily dose - 0.0008 g (0.8 mg).

Side effects:
In case of an overdose of Celanid, extrasystole, bigeminia (heart rhythm disturbance), rhythm dissociation (change in the source of the heart rhythm) may occur; in these cases, it is necessary to reduce the dose during subsequent injections and increase the intervals between individual infusions, and prescribe potassium preparations. In case of a sharp slowdown in the pulse, the injections are stopped. Nausea and vomiting are possible.

Contraindication:
Sharp organic changes in the heart and blood vessels, acute myocarditis (inflammation of the heart muscle), endocarditis (disease of the internal cavities of the heart), pronounced cardiosclerosis (destructive changes in the heart muscle). Caution is required in thyrotoxicosis (thyroid disease) and atrial extrasystole (a type of heart rhythm disorder).

Release form:
Tablets of 0.25 mg in a package of 30 pieces; ampoules of 1 ml of 0.02% solution in a package of 10 pieces; vials of 10 ml of 0.05% solution.

Storage conditions:
List A. In a place protected from light.

Synonyms:
Isolanid, Lanatozid C, Cedisanol, Cedistabil, Cedilanid, Celadigal, Ceglunate, Kristalanate C, Digilanid C, Lanacroist, Lanatigen C.

additionally:
Glycoside obtained from the leaves of foxglove (Digitalis lanata Ehrh.).