Instructions for Celista oral spray 0.1 mg/ml bottle 50 ml
Composition
active ingredient: miramistin;
1 ml of solution contains 0.1 mg of miramistin;
excipient: purified water
Dosage form
Oral spray.
Main physicochemical properties: colorless or with a yellowish tinge, transparent liquid,
that foams when shaken.
Pharmacotherapeutic group
Antiseptics and disinfectants. ATX code D08A J.
Pharmacological properties
Pharmacodynamics
The action of Miramistin is based on the direct hydrophobic interaction of the molecule with the lipids of the membranes of microorganisms, which leads to their fragmentation and destruction. At the same time, part of the Miramistin molecule, immersing in the hydrophobic area of the membrane, destroys the supramembrane layer, loosens the membrane, increases its permeability for high-molecular substances, changes the enzymatic activity of the microbial cell, inhibiting enzyme systems, which leads to the suppression of the vital activity of microorganisms and their cytolysis.
Unlike other antiseptics, Miramistin has a high selectivity of action against microorganisms, since it has almost no effect on the membranes of human cells. This effect is associated with a different structure of human cell membranes (a significantly longer length of lipid radicals, which sharply limits the possibility of hydrophobic interaction of Miramistin with cells).
Miramistin has a pronounced antimicrobial effect against gram-positive and gram-negative, aerobic and anaerobic, spore-forming and asporogenic bacteria in the form of monocultures and microbial associations, including hospital strains.
It has an antifungal effect on ascomycetes of the genus Aspergillus and the genus Penicillium, yeast (Rhodotorula rubra, Torulopsis gabrata) and yeast-like (Candida albicans, Candida tropicalis, Candida krusei) fungi, dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violaceum, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis), as well as other pathogenic fungi (for example, Pityrosporum orbiculare (Malassezia furfur)) in the form of monocultures and microbial associations. Under the action of Miramistin, the resistance of microorganisms to antibiotics decreases.
Pharmacokinetics
When applied topically, it is not absorbed through mucous membranes.
Indication
Comprehensive treatment of candidiasis of the oral mucosa. Comprehensive treatment of acute and chronic tonsillitis. Treatment of stomatitis, gingivitis; prevention of microbial complications after 2 surgical interventions on the oral mucosa. Comprehensive treatment of acute pharyngitis and/or exacerbation of chronic tonsillitis in children aged 3 years and older.
Contraindication
Individual sensitivity to Miramistin.
Interaction with other medicinal products and other types of interactions
With the simultaneous use of antibiotics with Miramistin, a decrease in the resistance of microorganisms to antibiotics is observed.
Ability to influence reaction speed when driving vehicles or other mechanisms
The use of the drug is characterized by the absence of any effect on the ability to drive vehicles and engage in other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.
Use during pregnancy or breastfeeding
Since the absorption of the drug Celista® is almost non-existent, it can be used during pregnancy or breastfeeding.
Method of administration and doses
The spray is applied topically to adults by spraying it into the oral cavity.
Treatment of candidiasis of the oral mucosa should be carried out
by spraying the medicine 2-4 times a day.
When treating tonsillitis, spray in the mouth and/or throat 3-4 times a day.
When treating stomatitis and gingivitis, it is necessary to spray the medicine in
oral cavity 3-4 times a day.
Children aged 3 years and over: for acute pharyngitis and/or exacerbation of chronic tonsillitis
perform irrigation of the pharynx using a spray nozzle; for children aged 3-6 years: by pressing the spray nozzle head once, 3-4 times a day; for children aged 7-14 years - by pressing twice, 3-4 times a day; for children over 14 years, by pressing 3-4 times, 3-4 times a day.
The duration of therapy is from 4 to 10 days depending on
clinical outcome and timing of remission.
Children.
Used for children aged 3 years and over.
Overdose
Overdose phenomena were not observed.
Adverse reactions
Immune system disorders: hypersensitivity reactions.
Other: in some cases, a short-term burning sensation is possible, which disappears on its own 15-20 seconds after applying the drug and does not require its withdrawal.
Expiration date
2 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 ° C. Do not freeze. Keep out of the reach of children.
Packaging
50 ml in a bottle; 1 bottle with a spray nozzle in a pack.
Vacation category
Without a prescription.
Producer
PrJSC "Pharmaceutical Company "Darnitsa".
Location of the manufacturer and its business address.
Ukraine, 02093, Kyiv, Boryspilska St., 13.
