Instructions Chlorhexidine solution for external use 0.05% bottle 100 ml
Composition
active ingredient: chlorhexidine digluconate;
100 ml of the drug contain 20% chlorhexidine digluconate solution - 0.25 ml;
excipient: purified water.
Dosage form
Solution for external use.
Main physicochemical properties: clear, colorless, odorless liquid.
Pharmacotherapeutic group
Antiseptics and disinfectants.
ATX code D08A C02.
Pharmacodynamics
Chlorhexidine digluconate is a cationic biguanide. Chlorhexidine has amino groups of cellular proteins. Penetrates into the intracellular membranes of bacterial cells, settles in the cytoplasm and changes the function of the membrane, preventing oxygen consumption, which causes a decrease in the level of adenosine triphosphate and cell death. Destroys DNA and disrupts DNA synthesis in microorganisms. Provides long-lasting persistent antimicrobial activity, preventing the reproduction of microorganisms for at least 6 hours after application of the drug.
Chlorhexidine digluconate has a rapid and pronounced effect on gram-positive and gram-negative bacteria (Treponema pallidum, Chlamidia spp., Ureaplasma spp., Neisseria gonorrhoeae, Gardnerella vaginalis, Bacteroides fragilis), protozoa (Trichomonas vaginalis), viruses (Herpes virus). In the presence of blood and other organic substances, the antimicrobial activity of chlorhexidine digluconate does not decrease.
Pharmacokinetics
Does not penetrate intact skin. Practically not absorbed from the gastrointestinal tract. After accidental ingestion of 300 mg, the maximum concentration is reached after 30 minutes and is 0.206 μg/l. It is excreted mainly with feces (90%), less than 1% is excreted by the kidneys.
Indication
Prevention of sexually transmitted infections (syphilis, gonorrhea, trichomoniasis, chlamydia, ureaplasmosis, genital herpes).
Disinfection of purulent wounds, infected burn surfaces; treatment of skin and mucous membrane infections in surgery, obstetrics, gynecology, urology (urethritis, urethroprostatitis), dentistry (rinsing and irrigation - gingivitis, stomatitis, aphthae, periodontitis, alveolitis).
Contraindication
Hypersensitivity to the components of the drug. Tendency to allergic reactions and allergic diseases, dermatitis, viral skin diseases. It is not recommended to use for treating the conjunctiva and washing cavities. It is also not recommended to use on wounds with a large surface area, during operations in the areas of the central nervous system and auditory canal, in ophthalmology, for introduction into the auditory canal.
Interaction with other medicinal products and other types of interactions
To avoid the development of dermatitis, it is not advisable to use chlorhexidine and iodine preparations simultaneously.
Compatible with drugs containing a cationic group (benzalkonium chloride, cetrimonium bromide).
Ethanol enhances the effect of the drug.
Chlorhexidine digluconate is a cationic substance and is incompatible with soap and other anionic substances (colloids, gum arabic, carboxymethylcellulose). At a concentration of 0.05%, chlorhexidine digluconate is incompatible with borates, carbonates, chlorides, citrates, phosphates, sulfates, since insoluble precipitates are formed.
Application features
It is necessary to avoid getting the drug inside the wound in patients with open head injury, spinal cord injury, perforation of the eardrum. If the solution gets on the mucous membranes of the eyes, they should be quickly and thoroughly washed with water.
Contact with hypochlorite bleaching agents on tissues that have previously been in contact with preparations containing chlorhexidine may contribute to the appearance of brown stains on them.
The bactericidal effect of the drug increases with increasing temperature. At temperatures above 100 °C, the drug partially decomposes.
The drug is practically not absorbed in the stomach. In case of accidental ingestion, the stomach should be washed using raw milk, raw egg, gelatin. If necessary, symptomatic therapy should be carried out.
Do not dilute with hard water. Can be sterilized in an autoclave at 116°C for 30 minutes. Do not sterilize with ionizing radiation.
You should not violate the rules for using the medicine - this can harm your health.
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Use during pregnancy or breastfeeding
During pregnancy or breastfeeding, the drug should be used only if the expected benefit to the mother outweighs the potential risk to the fetus/child. Do not treat the surface of the mammary glands before breastfeeding.
Method of administration and doses
For the prevention of sexually transmitted infections, the drug is effective if used no later than 2 hours after sexual intercourse. Before using the drug for the prevention of sexually transmitted diseases, you should empty your bladder, wash your hands and genitals. After that, treat the skin of the pubis, inner thighs, and genitals with a jet of solution. The contents of the bottle are introduced into the urethra using a nozzle: for men - 2-3 ml, for women - 1-2 ml (for women, 5-10 ml should be injected into the vagina and held for 2-3 minutes). Treat the skin of the inner thighs, pubis, and genitals with the solution. After the procedure, do not empty your bladder for 2 hours.
Comprehensive treatment of urethritis and urethroprostatitis is carried out by injecting 2-3 ml of chlorhexidine digluconate solution into the urethra 1-2 times a day, the course of treatment is 10 days. The procedures are prescribed every other day.
The drug solution should be used in the form of irrigations, rinses and applications - apply 5-10 ml of the solution to the affected surface of the skin or mucous membranes with exposure for 1-3 minutes 2-3 times a day (on a swab or by irrigation).
During pregnancy or breastfeeding, the drug should be used in the usual recommended doses.
Children
Do not use in children under 12 years of age.
Overdose
Cases of overdose with external use are unknown.
Incorrect oral administration of a large amount of the substance (300 ml of chlorhexidine) leads to death with signs of liver and kidney failure.
If ingested, the drug is practically not absorbed - the stomach should be rinsed using milk, gelatin, or a raw egg.
If necessary, symptomatic therapy is performed.
Adverse reactions
In some cases, with increased individual sensitivity, hypersensitivity reactions, dryness and itching of the skin, dermatitis, stickiness of the skin of the hands, which is observed for 3-5 minutes, photosensitization are possible. In the treatment of gingivitis - discoloration of tooth enamel, tartar deposits, taste disturbances.
If any adverse reactions occur, discontinue use of the drug and consult a doctor.
Expiration date
3 years.
Do not use after the expiry date stated on the packaging.
Storage conditions
Store in original packaging at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Packaging
100 ml in a bottle in a pack or without a pack or 200 ml in bottles.
Vacation category
Without a prescription.
Producer
PrJSC Pharmaceutical Factory "Viola".
Location of the manufacturer and its business address
Ukraine, 69063, Zaporizhia, Akademika Amosova St., 75.
