Combinil Duo eye/ear drops bottle 5 ml

Duo Combin eye and ear drops are indicated for infections caused by microorganisms sensitive to ciprofloxacin:

Composition

Active ingredients: ciprofloxacin hydrochloride and dexamethasone;

1 ml of the drug solution contains ciprofloxacin hydrochloride equivalent to ciprofloxacin 3 mg dexamethasone ˗ 1 mg;

Excipients: sodium edetate, benzalkonium chloride, mannitol (E 421), hydroxypropyl-beta-cyclodextrin, hydrochloric acid, water for injections.

Contraindication

Method of application

The drug should be used as instillations for adult patients.

In ophthalmology: 1-2 drops in the conjunctival sac of one or both eyes every 6 hours. After 1-2 days of use, if necessary, the dose can be increased to 1-2 drops every 2 hours. After achieving a therapeutic effect, the dose and frequency of use should be reduced. The course of treatment is usually 7 days.

In otorhinolaryngology: 4 drops in the affected ear twice a day. The daily dose is 8 drops in one ear canal, which is 8 mg of dexamethasone and 24 mg of ciprofloxacin, respectively. The course of treatment is usually 7 days.

The external auditory canal should be thoroughly cleaned. To prevent vestibular stimulation, it is recommended to administer a solution at room temperature or body temperature.

The patient should be in a lying position on the opposite side of the affected ear. It is advisable to stay in this position for 5-10 minutes. Also, after local cleaning, a moistened gauze or hygroscopic cotton swab can be inserted into the ear canal for 1-2 days, but it must be moistened to be saturated with the drug 2 times a day.

Application features

Pregnant women

Do not prescribe during pregnancy and breastfeeding.

Children

Do not use on children.

Drivers

With caution.

Overdose

Symptoms: Increased symptoms of side effects (keratitis, erythema, eyelid edema, lacrimation).

Treatment. The drug should be discontinued. When applying the drug to the eye(s), rinse with plenty of warm water; when applying the drug to the ear, the patient should turn the head to the side and wait for the excess drug to drain from the ear.

Side effects

Since the drug consists of two components, adverse reactions characteristic of both components may occur.

Adverse reactions caused by ciprofloxacin. General disorders and administration site conditions: hyperthermia, drug intolerance.

Adverse reactions caused by dexamethasone: A common side effect observed during clinical trials was ocular discomfort.

Interaction

Since the drug is applied topically, the severity of interactions with drugs used systemically is unlikely, but interactions cannot be ruled out:

Storage conditions

Store at a temperature of 15 °C to 25 °C in a place protected from light.

Keep out of reach of children.

Shelf life - 3 years.

The shelf life after opening the bottle is 45 days.