Instructions for Corvalol K soft capsules blister No. 30
Composition
active ingredients: ethyl ester of a-bromoisovaleric acid, solution of menthol in menthyl ester of isovaleric acid, peppermint oil, hop oil;
1 capsule contains 16.63 mg of ethyl ester of a-bromoisovaleric acid, 45.74 mg of menthol solution in menthyl ester of isovaleric acid, 0.17 mg of hop oil, 1.18 mg of peppermint oil;
excipients: sunflower oil, sucralose, glycerol monostearate, colloidal anhydrous silicon dioxide;
capsule shell composition: gelatin, glycerin, liquid maltitol, microcrystalline cellulose - guar gum, potato starch, xylitol, sodium methylparaben (E 219), sodium propylparaben (E 217), lemon flavoring, purified water.
Dosage form
Soft capsules.
Main physicochemical properties: soft gelatin capsules of oval shape from light yellow to light brown color. The contents of the capsules are an oily suspension with a characteristic odor.
Pharmacotherapeutic group
Hypnotics and sedatives. Combinations of hypnotics and sedatives, excluding barbiturates. ATX code N05C X.
Pharmacological properties
Pharmacodynamics.
Corvalol® K is a sedative and antispasmodic, the effect of which as a complex drug is determined by the components that make up its composition.
Ethyl ester of α-bromosovaleric acid exhibits a reflex sedative and antispasmodic effect, caused by irritation mainly of receptors of the oral cavity and nasopharynx, a decrease in reflex excitability in the central nervous system, an increase in inhibition in neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of central vasomotor centers and a direct local antispasmodic effect on vascular smooth muscle.
Validol or a solution of menthol in menthyl ester of isovaleric acid has a sedative and moderate coronary dilating effect due to its effect on the sensitive nerve receptors of the oral mucosa.
Peppermint oil contains essential oils, approximately 50% menthol and 4-9% menthol esters. They are able to irritate the "cold" receptors of the oral cavity and reflexively dilate the vessels of the heart and brain, causing a calming and mild choleretic effect. Peppermint oil has antiseptic, antispasmodic effects, and the ability to eliminate flatulence. Irritating the receptors of the gastric and intestinal mucosa, it enhances intestinal peristalsis.
Hop oil has a reflex vasodilator and antispasmodic effect, eliminates the phenomena of flatulence.
Pharmacokinetics.
When taken under the tongue, the absorption of the drug begins already from the oral mucosa. The effect develops after 5 minutes and lasts for 3–6 hours.
Indication
– Neuroses with increased irritability;
– in the complex therapy of arterial hypertension and vegetative-vascular dystonia;
– mild coronary spasms, tachycardia;
– intestinal cramps.
Contraindication
– Hypersensitivity to the components of the drug, bromine;
– severe arterial hypotension;
– acute myocardial infarction.
Interaction with other medicinal products and other types of interactions
Corvalol® K enhances the sedative effect of psychotropic drugs, opioid analgesics, alcohol, and anesthetics when used simultaneously.
Potentiation of the action of antihypertensive drugs is possible when used simultaneously with Corvalol® K.
Corvalol® K reduces headaches caused by taking nitrates.
Application features
In cases where pain in the heart area does not go away after taking the drug, it is necessary to consult a doctor to rule out acute coronary syndrome.
This medicine contains less than 1 mmol (23 mg) sodium per dose, i.e. essentially sodium-free.
Excipients included in the preparation may cause allergic reactions (possibly delayed).
Use during pregnancy or breastfeeding
The use of the drug during pregnancy or breastfeeding is possible if, in the opinion of the doctor, the expected positive effect for the mother outweighs the potential risk to the fetus/child.
Ability to influence reaction speed when driving vehicles or other mechanisms
Side effects (dizziness and drowsiness) are possible in the first hours after administration. Therefore, caution should be exercised when using the drug by persons working with complex mechanisms and drivers of vehicles.
Method of administration and doses
Corvalol® K capsules are taken under the tongue. The capsule is kept under the tongue until it is completely dissolved. To speed up the effect, you can crush the capsule with your teeth.
Take 1 capsule 2-3 times a day, regardless of meals. If necessary (pronounced tachycardia and spasm of coronary vessels), a single dose can be increased to 2 capsules.
The duration of use of the drug is determined by the doctor depending on the clinical effect and tolerability of the drug.
Children
There is no experience in the treatment of children.
Overdose
Symptoms: headache, nausea, agitation, cardiac dysfunction, central nervous system depression, decreased blood pressure.
Treatment: drug withdrawal and symptomatic treatment.
Adverse reactions
Corvalol® K is generally well tolerated. In some cases, the following side effects may occur:
from the nervous system: drowsiness, dizziness, decreased concentration;
from the digestive tract: abdominal discomfort, mild nausea;
from the immune system: allergic reactions, including angioedema, urticaria, rash, itching;
others: short-term arterial hypotension, lacrimation.
Prolonged use of bromine-containing drugs can lead to bromine poisoning, which is characterized by the following symptoms: central nervous system depression, depressed mood, apathy, confusion, ataxia, purpura, rhinitis, conjunctivitis. These phenomena resolve when the dose is reduced or the drug is discontinued.
Expiration date
1 year 6 months.
Do not use the drug after the expiration date indicated on the package.
Storage conditions
Store in original packaging at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Packaging
10 capsules in a blister. 1 or 3 blisters in a pack.
Vacation category
Without a prescription.
Producer
PJSC "Farmak".
Location of the manufacturer and its business address
Ukraine, 04080, Kyiv, Frunze St., 74.
