Cuprenil film-coated tablets 250 mg, can No. 100

Kuprenil tablets are indicated for:

Severe active rheumatoid arthritis; Wilson's disease (hepatolenticular degeneration); cystinuria; lead poisoning.

Composition

Active ingredient: penicillamine;

1 tablet contains penicillamine 250 mg; and

Excipients: lactose, potato starch, povidone, talc, magnesium stearate, hypromellose, polyethylene glycol, titanium dioxide (E 171), azorubine (E 122).

Contraindication

Hypersensitivity to the components of the drug. Systemic lupus erythematosus. Pregnancy (except in cases of Wilson's disease in the pregnant woman) and breastfeeding. Aplastic anemia or agranulocytosis in history associated with penicillamine. Rheumatoid arthritis with simultaneous or a history of renal dysfunction, due to the possibility of a negative effect of penicillamine on the kidneys. Chronic lead poisoning in case of X-ray confirmed presence of lead in the digestive tract. The use of the drug can be started after removal of lead from the digestive tract. Animal studies show that penicillamine may be ineffective and dangerous if excessive lead intake occurs during its use. Simultaneous use of gold preparations, antimalarials, cytostatics, oxyphenylbutazone, which, like penicillamine, cause adverse reactions from the hematopoietic system and kidneys. Moderate or severe renal insufficiency. Severe thrombocytopenia associated with penicillamine.

Method of application

The dose depends on the indications. Kuprenil® is taken at least 30 minutes before meals.

Application features

Pregnant women

Contraindicated except in cases of Wilson's disease in pregnant women.

Children

Used for children over 12 years of age.

Drivers

Does not affect.

Overdose

No cases of acute poisoning with penicillamine have been observed. However, in therapeutic doses, the drug can cause various undesirable side effects.

Acute allergic reactions may occur, especially at the beginning of treatment.

Cross-sensitization with penicillamine is possible.

Treatment is symptomatic.

Side effects

Gastrointestinal tract: mouth ulcers, anorexia, nausea, vomiting, diarrhea, stomatitis, glossitis, complete loss or distortion of taste sensations, acute colitis, ileal ulcers, stenosis, elastosis. Skin: elastic pseudoxanthoma, skin weakness, penicillin-induced lupus erythematosus, collagen and elastin metabolism disorders, oral lichen planus, alopecia, Stevens-Johnson syndrome, bullous epidermolysis. Musculoskeletal system: rheumatoid arthritis, septic arthritis, back pain, polymyositis, dermatomyositis. Blood and lymphatic system: agranulocytosis and aplastic anemia with fatal outcome, myelotoxicity and myelosuppression, thrombocytopenic purpura, eosinophilia. Nervous system: worsening of Wilson's neurological symptoms (dystonia, rigidity, dysarthria), reversible polyneuritis (associated with pyridoxine deficiency), polyneuritis, sensory and motor neuropathies, myasthenia gravis.

Interaction

Cuprenil® increases the body's need for vitamin B6.

Cuprenil® should not be used together with drugs that suppress bone marrow function, such as gold preparations, antimalarials, cytostatics, oxyphenylbutazone, phenylbutazone.

Storage conditions

Store at a temperature not exceeding 25 °C out of the reach of children.

Shelf life - 3 years.