Depiofen film-coated tablets 25 mg blister No. 10

Depiofen film-coated tablets are indicated for the short-term symptomatic treatment of acute pain of mild to moderate severity, e.g. musculoskeletal pain, painful menstruation (dysmenorrhea), toothache.

Composition

Active ingredient: dexketoprofen trometamol;

1 tablet contains dexketoprofen trometamol equivalent to dexketoprofen 25 mg;

Excipients: corn starch, microcrystalline cellulose, sodium starch (type A), colloidal silicon dioxide, magnesium stearate;

Tablet coating: titanium dioxide (E 171), hypromellose, polyethylene glycol 6000, talc.

Contraindication

Method of application

Adults. Depending on the type and intensity of pain, the recommended dose is 12.5 mg every 4-6 hours or 25 mg every 8 hours. The daily dose should not exceed 75 mg. Undesirable effects of the drug can be minimized by using the minimum effective dose for the shortest possible time necessary to eliminate symptoms. Depiofen is not intended for long-term therapy; treatment should be limited to the time of symptoms. Simultaneous food intake reduces the rate of absorption of the active substance, so it is recommended to take it at least 30 minutes before meals.

Application features

Pregnant women

Contraindicated in the third trimester of pregnancy. The use of the drug in the first and second trimesters of pregnancy is possible only if the expected benefit to the mother outweighs the possible risk to the fetus, and the dose and duration of treatment should be reduced to the minimum possible.

Children

Should not be used.

Drivers

With caution.

Overdose

Symptoms of overdose are unknown. Similar drugs cause disorders of the digestive tract (vomiting, anorexia, abdominal pain) and the nervous system (drowsiness, dizziness, disorientation, headache).

In case of accidental overdose, symptomatic treatment should be initiated immediately according to the patient's condition. Dexketoprofen is removed from the body by dialysis.

Side effects

Gastrointestinal tract: nausea, vomiting, abdominal pain, dyspepsia, diarrhea, constipation, vomiting with blood, dry mouth.

Interaction

Other NSAIDs, including selective cyclooxygenase-2 inhibitors and high doses of salicylates (≥3 g/day). The simultaneous use of several NSAIDs increases the risk of gastrointestinal ulcers and bleeding due to their mutual potentiation of their effects.

Anticoagulants NSAIDs enhance the effect of anticoagulants, such as warfarin, due to the high degree of binding of dexketoprofen to blood plasma proteins, as well as inhibition of platelet function and damage to the gastric and duodenal mucosa. If simultaneous use is necessary, it should be carried out under the supervision of a physician and monitoring of relevant laboratory parameters.

Heparin increases the risk of bleeding (due to inhibition of platelet function and damage to the gastric and duodenal mucosa). If concomitant use is necessary, it should be carried out under the supervision of a physician with monitoring of relevant laboratory parameters.

Storage conditions

Store at a temperature not exceeding 30 °C in the original packaging to protect from light.

Keep out of reach of children.

Shelf life - 2 years.