Depot - is a combination of soluble and sparingly soluble betamethasone esters for intramuscular, intraarticular, periarticular, intrasynovial and intradermal injections, as well as for administration directly to the lesion. Depot has high glucocorticosteroid activity and insignificant mineralocorticosteroid activity.
Indications for use
dermatological diseases: atopic dermatitis, neurodermatitis, contact dermatitis, severe solar dermatitis; rheumatic conditions: rheumatoid arthritis, osteoarthritis, bursitis, tendosynovitis, tendonitis; collagen diseases: systemic lupus erythematosus, scleroderma; oncological diseases: palliative therapy of leukemia and lymphoma in adults, acute leukemia in children.
Warehouse
1 ml of suspension contains 6.43 mg of micronized betamethasone dipropionate in terms of 100% dry matter (equivalent to 5 mg of betamethasone), 2.63 mg of betamethasone sodium phosphate in terms of 100% anhydrous matter (equivalent to 2 mg of betamethasone); excipients: methylparaben (E 218), propylparaben (E 216), benzyl alcohol, sodium chloride, anhydrous sodium hydrogen phosphate, disodium edetate, sodium carboxymethylcellulose, polysorbate 80, polyethylene glycol 4000, water for injections.
Contraindication
Hypersensitivity to betamethasone, other components of the drug or to other glucocorticosteroids. Systemic mycoses. Intramuscular administration in patients with idiopathic thrombocytopenic purpura.
Method of application
Systemic application
The initial dose of the drug in most cases is 1-2 ml. The injection is repeated if necessary, depending on the patient's condition. The drug is administered deep intramuscularly into the buttock.
Topical application
In acute bursitis, injecting 1-2 ml of Depo into the bursa can relieve pain and restore full mobility within a few hours.
In rheumatoid arthritis and osteoarthritis, intra-articular administration of the drug in a dose of 0.5-2 ml reduces pain, tenderness, and stiffness of the joints within 2-4 hours after administration. The duration of the therapeutic effect of the drug varies significantly and can be 4 weeks or more.
Application features
Serious neurological events, some of which were fatal, have been reported following epidural corticosteroid injection. Other events have included reports of spinal cord infarction, paraplegia, quadriplegia, cortical blindness, and stroke. These serious neurological events have occurred with and without the use of fluoroscopy.
Pregnant women
Due to the lack of controlled studies on the safety of the drug, pregnant women, breastfeeding women, and women of reproductive age should be prescribed the drug after careful assessment of the benefit to the mother and the potential risk to the fetus/child.
Children
There is insufficient clinical data on the use of the drug in children, therefore it is undesirable to use it in patients of this age category (possible growth retardation and development of secondary adrenal insufficiency).
Drivers
It is recommended to refrain from driving or operating other mechanisms during treatment with the drug.
Overdose
Administration of high doses of glucocorticosteroids for several days does not lead to undesirable effects (except in cases of very high doses or in cases of use in diabetes mellitus, glaucoma, exacerbation of erosive-ulcerative lesions of the gastrointestinal tract, in cases of use in patients who are simultaneously undergoing therapy with cardiac glycosides, indirect anticoagulants or potassium-sparing diuretics).
Side effects
Disturbances of water and electrolyte balance: natriemia, increased potassium excretion, hypokalemic alkalosis, increased calcium excretion.
Cardiovascular system: congestive heart failure in patients predisposed to this disease; arterial hypertension.
On the part of the digestive system: hiccups, erosive-ulcerative lesions of the stomach with possible perforation and bleeding, esophageal ulcers, pancreatitis, flatulence, intestinal perforation, nausea, vomiting.
Storage conditions
Store in the original packaging at a temperature not exceeding 25°C. Do not freeze. Keep out of the reach of children.
