Depressant tablets 10 mg No. 30

Depresan - antidepressant. Indications for use - major depressive episodes; panic disorders; social anxiety disorders; generalized anxiety disorders; obsessive-compulsive disorders.

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Contraindication

Hypersensitivity to escitalopram or to other components of the drug;

simultaneous treatment with non-selective irreversible monoamine oxidase inhibitors (MAOIs), as there is a risk of developing serotonin syndrome, manifested by agitation, tremor, hyperthermia; combination with reversible MAO-A inhibitors (e.g. moclobemide)

Method of application

The safety of doses above 20 mg per day has not been established.

Depresan should be administered orally to adults once a day, regardless of meals.

Major depressive episode.

Usually 10 mg should be prescribed once a day.

Panic disorders with or without agoraphobia.

An initial dose of 5 mg per day is recommended during the first week, after which the dose can be increased to 10 mg per day.

Social anxiety disorders (social phobia).

Usually 10 mg should be prescribed once a day.

Generalized anxiety disorders.

Administer 10 mg once daily. Depending on individual sensitivity, the dose may be increased to a maximum of 20 mg per day.

Discontinuation of treatment.

Treatment with Depresan should be discontinued gradually, reducing the dose over 1-2 weeks, to avoid a withdrawal reaction.

Application features

The following features of use apply to the therapeutic group of SSRIs.

Paradoxical anxiety.

Some patients with panic disorder may experience increased anxiety when starting SSRI treatment. This paradoxical reaction usually resolves within 2 weeks of treatment. To reduce the likelihood of anxiogenic effects, low initial doses are recommended.

Convulsive attacks.

Escitalopram should be discontinued if the patient develops a seizure for the first time or if the seizure frequency increases (in patients with a known diagnosis of epilepsy).

Mania.

SSRIs should be used with caution in patients with a history of mania/hypomania. If a manic state occurs, the SSRI should be discontinued.

Diabetes.

In patients with diabetes mellitus, treatment with SSRIs may alter glycemic control (hypoglycemia or hyperglycemia). Dosage of insulin and/or oral hypoglycemic agents may need to be adjusted.

Pregnant women

Clinical data on the use of escitalopram in pregnant women are limited.

Escitalopram is contraindicated in pregnant women, except in cases where the need for the drug has been clearly demonstrated after careful consideration of all risks and benefits.

Children

Depresan should not be used to treat children under 18 years of age.

Drivers

Although escitalopram does not affect intellectual or psychomotor functioning, any psychoactive drug may impair the skills or ability to think rationally.

Overdose

Toxicity: Clinical data on overdose with escitalopram are limited. Many cases were caused by concomitant overdose with other drugs. In most cases, symptoms of overdose were mild or asymptomatic.

Side effects

From the cardiovascular system - tachycardia, bradycardia.

From the blood and lymphatic system - thrombocytopenia.

From the nervous system - headache, insomnia, drowsiness, dizziness, paresthesia, tremor, taste disturbances, sleep disorders, loss of consciousness.

On the part of the digestive system - nausea, diarrhea, constipation, vomiting, dry mouth, gastrointestinal bleeding (also rectal).

On the part of the skin and subcutaneous tissue - increased sweating, urticaria, alopecia, rashes, itching, bruises, edema.

Storage conditions

Store in the original packaging at a temperature not exceeding 25 °C.

Keep out of reach of children.