Dermadrin ointment 20 mg/g tube 20 g

Pharmacological properties

Pharmacodynamics. Dermadrin contains the H1-receptor blocker diphenhydramine, which selectively inhibits histamine H1-receptors. Diphenhydramine is an effective antihistamine that eliminates the manifestations of allergies and itching; additionally has a local anesthetic and analgesic effect. Effectively eliminates swelling and irritation after insect and bee bites, sun and thermal burns, photodermatosis. The basis of the ointment is a water-oil emulsion, which causes the cooling effect of the drug. When applied topically, the active ingredient of the ointment penetrates the skin and subcutaneous layers. The antipruritic and analgesic effect occurs immediately after applying the ointment and lasts 2-6 hours.

Pharmacokinetics. After application to the skin, a therapeutically effective concentration is maintained directly at the site of application. The amount of diphenhydramine absorbed through the skin is directly proportional to the size of the application area and the period of contact with the skin of Dermadrin ointment. When diphenhydramine is absorbed through the skin, there is no systemic effect of the drug.

Indication

Allergic dermatitis; itchy dermatoses; dermatitis with local painful manifestations; urticaria; eczema; insect bites; thermal and sunburns of the first degree; photodermatosis (sun allergy).

Application

Externally on the skin. Depending on the size of the affected area, it is recommended to apply in an amount from the size of a cherry to a walnut, which is 1-3 g.

Adults: apply 4-6 times a day. Children aged 2-12 years: 4-5 times a day. It is not recommended to use more than 15 g of Dermadrin ointment per day. The duration of treatment depends on the extent of the lesion.

Contraindication

Hypersensitivity to diphenhydramine hydrochloride or other antihistamines; age up to 2 years. Dermadrin ointment is not recommended for application to open wounds and large areas of affected skin, especially with varicose veins, measles, vesicular skin lesions.

Side effects

In general, Dermadrin ointment is well tolerated. However, the possibility of developing hypersensitivity reactions cannot be ruled out.

Special instructions

Avoid contact with the eyes. Due to the possibility of photosensitivity reactions, direct sunlight should be avoided on areas of skin where Dermadrin ointment is applied.

Use during pregnancy and breastfeeding

Dermadrin ointment is not recommended for use in the first trimester of pregnancy. It should be used with caution in the second and third trimesters of pregnancy. During breastfeeding, it should be remembered that the active ingredient of the ointment, diphenhydramine hydrochloride, may pass into breast milk.

Before using the drug during pregnancy and breastfeeding, you should consult a doctor!

Ability to influence the ability to drive vehicles and work with mechanisms. The drug does not affect the ability to drive vehicles and work with mechanisms. Does not affect the psychophysical state and does not cause drowsiness.

Interactions

Not detected.

Overdose

Not observed; when applying Dermadrin ointment topically, the likelihood of an overdose is virtually non-existent.

Storage conditions

In a place protected from light at a temperature not exceeding 25 °C.