Instructions Diagnol powder for oral solution 64 g package 73.69 g No. 4
Composition
active ingredient: macrogol;
1 packet contains polyethylene glycol 4000 (macrogol 4000) – 64 g;
excipients: sodium sulfate anhydrous, sodium bicarbonate, sodium chloride, potassium chloride, sodium saccharin.
Dosage form
Powder for oral solution.
Main physicochemical properties: white or almost white powder.
Pharmacotherapeutic group
Osmotic laxatives. ATX code A06A D15.
Pharmacological properties
Pharmacodynamics
By forming hydrogen bonds with water molecules, Diagnol® retains it in the intestine. Water dilutes and increases the contents of the intestine along its entire length. After that, the drug is completely evacuated from the intestine along with its contents.
Pharmacokinetics
The drug is not absorbed or metabolized. It is excreted from the body unchanged.
Indication
Colon cleansing to prepare patients for:
- endoscopic and X-ray examinations of the intestines;
- surgical interventions on the intestines.
Contraindication
Hypersensitivity to the components of the drug. Dehydration, severe heart failure; carcinoma or any other severe intestinal diseases accompanied by damage to the mucous membrane (Crohn's disease, nonspecific ulcerative colitis); intestinal obstruction or the possibility of developing intestinal obstruction; intestinal perforation or the threat of its occurrence. Toxic megacolon, abdominal pain of undetermined origin.
Interaction with other medicinal products and other types of interactions
It is not advisable to use other medications while taking the drug, as they may be excreted from the gastrointestinal tract, their absorption may be reduced or completely stopped. If these medications are considered vital, they should be avoided in oral form, used in a different dosage form, or an alternative should be found.
Application features
Elderly people are recommended to use the drug under the supervision of a doctor.
Diagnol® does not contain sugar, so it can be prescribed to patients with diabetes mellitus, as well as to individuals whose diet excludes galactose.
The drug should be used with caution in patients at risk of fluid and electrolyte imbalance (e.g. patients with impaired liver or kidney function, concomitant use of diuretics). Isolated cases of fluid and electrolyte imbalance have been reported in patients at risk.
Patients prone to aspiration, bedridden, or patients with neurological swallowing disorders are recommended to use the drug with caution, under the supervision of a physician, only in a sitting position and through a nasogastric tube, since such patients may develop aspiration pneumonia.
Patients with heart or kidney failure may develop acute pulmonary edema due to excessive sodium hydroxide intake.
Use during pregnancy or breastfeeding
Pregnancy
Experience with the use of the drug during pregnancy is insufficient, therefore it should be used during pregnancy only if absolutely necessary.
Breast-feeding
Since there is no significant absorption of macrogol 4000, Diagnol® can be used during breastfeeding if, in the opinion of the physician, the benefit to the mother outweighs the potential risk to the child.
Ability to influence reaction speed when driving vehicles or other mechanisms
Not installed.
Method of administration and doses
For oral use.
The drug is intended for use by adults. Dissolve the contents of each sachet in 1 liter of water until the powder is completely dissolved.
The dosage should be set at the rate of approximately 1 liter of solution per 15-20 kg of body weight. The dose is 3-4 liters of solution depending on the patient's body weight.
The drug can be used in one stage or in 2 stages, provided that the reconstituted solution is used in full (on average 3-4 liters of solution depending on the patient's body weight).
Training scheme.
One-step preparation: 4 liters the evening before the procedure, a break of 1 hour is possible after the first 2 liters.
Two-step preparation: 2 liters in the evening and 2 liters in the morning before the procedure, take the last glass 3-4 hours before the procedure, or 3 liters in the evening and 1 liter in the morning before the procedure, take the last glass 3-4 hours before the procedure.
The recommended rate of use of the drug is 1-1.5 liters per hour (250 ml every 10-15 minutes).
The doctor can individually determine the recommended dosage of the drug according to the patient's clinical condition and potential concomitant diseases.
Children
Do not use on children.
Overdose
Diarrhea. Treatment is symptomatic.
Adverse reactions
Skin and immune system disorders: Rarely, allergic reactions, including pruritus, urticaria, rash, angioedema, have been observed. Isolated cases of anaphylactic shock have been reported.
Expiration date
3 years.
Do not use the drug after the expiration date indicated on the package.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
73.69 g of powder per bag.
4 packets per pack.
Vacation category
According to the recipe.
Producer
PJSC "Farmak".
Location of the manufacturer and its business address
Ukraine, 04080, Kyiv, Frunze St., 74.
