Instructions for use Dibazol-Darnitsa tablets 20 mg No. 10
Composition
active ingredient: bendazole;
1 tablet contains bendazole hydrochloride 20 mg;
Excipients: lactose monohydrate, potato starch, talc, calcium stearate.
Dosage form
Pills.
Main physicochemical properties: white tablets, flat-cylindrical in shape, with a bevel.
Pharmacotherapeutic group
Peripheral vasodilator. ATC code C04A X.
Pharmacological properties
Pharmacodynamics
Bendazole is a vasodilator and antispasmodic. It has hypotensive, vasodilating effects, stimulates the function of the spinal cord, and has a moderate immunostimulating effect.
It has a direct antispasmodic effect on the smooth muscles of blood vessels and internal organs. The drug causes a short-term (2-3 hours) and moderate hypotensive effect, is well tolerated. Causes a short-term expansion of cerebral vessels in chronic cerebral hypoxia caused by local circulatory disorders (sclerosis of cerebral arteries). Facilitates synaptic transmission in the spinal cord.
Dibazol stimulates the production of antibodies, enhances the phagocytic activity of leukocytes and macrophages, and improves the synthesis of interferon, but the immunomodulatory effect of dibazol develops slowly.
Pharmacokinetics
Rapidly absorbed in the gastrointestinal tract. The therapeutic effect occurs 30-60 minutes after taking the drug. Duration of action is 2-3 hours. The drug is excreted mainly in the urine.
Indication
As an additional therapy for arterial hypertension. Diseases of the nervous system - residual effects of poliomyelitis, peripheral paralysis of the facial nerve, polyneuritis, flaccid paralysis syndrome.
Contraindication
Hypersensitivity to the drug. Diseases with decreased muscle tone, convulsive syndrome, severe heart failure. Hypotension. Chronic nephritis with edema and impaired nitrogen-excreting kidney function. Bleeding gastric and duodenal ulcers. Diabetes mellitus.
Interaction with other medicinal products and other types of interactions
If the patient is taking any other medications, it is imperative to consult a doctor regarding the possibility of using the drug.
Papaverine hydrochloride, theobromine, salsolin – when used in combination with dibazole, the spectrum of pharmacological action of papaverine hydrochloride, theobromine, salsolin expands.
Barbiturates – when used in combination with Dibazol, the effectiveness of long-acting barbiturates, in particular phenobarbital, is enhanced.
Phentolamine, antihypertensive drugs (drugs that affect the renin-angiotensin system), saluretics - when used in combination with dibazole, the hypotensive effect is enhanced.
β-blockers – when used in combination with dibazole, the hypotensive effect of the latter does not change, but with prolonged use, dibazole prevents the increase in total peripheral resistance caused by β-blockers.
Application features
Before starting treatment, you should consult a doctor!
Dibazol in tablet form is an auxiliary agent used for arterial hypertension in case of sensitivity to other antihypertensive drugs. In the treatment of arterial hypertension, it is recommended to combine it with other antihypertensive drugs.
Long-term use of Dybazol-Darnitsa as an antihypertensive agent in elderly patients is inappropriate due to the possibility of worsening ECG parameters and decreased cardiac output.
It is not recommended for long-term treatment of arterial hypertension, especially in elderly patients.
The drug contains lactose, therefore patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not take the drug.
Ability to influence reaction speed when driving vehicles or other mechanisms
During treatment, caution should be exercised when driving vehicles and working with complex mechanisms, and in case of dizziness, refrain from potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Use during pregnancy or breastfeeding
Do not use the drug during pregnancy or breastfeeding.
Method of administration and doses
Adults and children over 12 years of age should be prescribed the drug orally at a dose of 20-40 mg (1-2 tablets) 2-3 times a day. Take Dibazol-Darnitsa 2 hours before meals or 2 hours after meals.
The highest doses for adults orally: single dose – 40 mg, daily dose – 120 mg.
Children
The drug should not be prescribed to children under 12 years of age.
Overdose
Treatment: if the above symptoms occur, you should immediately consult a doctor. Before the doctor arrives, it is recommended to induce vomiting, rinse the stomach with activated charcoal. Prescribe a saline laxative. In case of hypotension, transfusion and symptomatic therapy (vasoconstrictors, cardiac glycosides) are recommended. There is no specific antidote.
Adverse reactions
From the nervous system: dizziness, headache;
from the cardiovascular system: feeling of palpitations, pain in the heart area, with prolonged use - deterioration of ECG indicators due to a decrease in cardiac output, a decrease in blood pressure;
from the respiratory system: dry cough, runny nose, difficulty breathing;
from the digestive system: nausea, burning in the throat;
from the immune system: itching, hyperemia, rash, urticaria;
general disorders: feeling hot, increased sweating, facial flushing.
Expiration date
3 years.
It is not recommended to use the drug after the expiration date indicated on the package.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
10 tablets in a contour blister pack.
Vacation category
Without a prescription.
Producer
PrJSC "Pharmaceutical Company "Darnitsa".
Location of the manufacturer and its business address
Ukraine, 02093, Kyiv, Boryspilska St., 13.
