Instructions for Dimexide solution for skin use, bottle 50 ml No. 1
Composition
active ingredient: dimethyl sulfoxide;
1 bottle contains 50 ml of dimethyl sulfoxide.
Dosage form
The solution is topical.
Main physicochemical properties: colorless liquid or colorless crystals. Hygroscopic.
Pharmacotherapeutic group
Topical agents for joint and muscle pain.
ATX code M02A X03.
Pharmacological properties
Pharmacodynamics.
Dimethyl sulfoxide has the property of penetrating biological membranes, including skin barriers, thus realizing its specific effects, which include anti-inflammatory, antipyretic, analgesic, antiseptic, moderate fibrinolytic. The drug enhances the penetration of drugs through intact skin and mucous membranes (transport ability).
Pharmacokinetics.
When applying a solution (90%) of Dimexide® Arterium to the skin, it is detected in the blood after 5 minutes, reaching a maximum concentration after 4-6 hours, with an almost constant level for 1.5-3 days. Dimethyl sulfoxide is excreted in urine and feces both in unchanged form and in the form of dimethyl sulfone.
Indication
As part of the complex therapy of inflammatory diseases of the musculoskeletal system: rheumatoid arthritis, Bekhterev's disease, deforming osteoarthritis (in the presence of periarticular tissue damage); in arthropathy, tendon sprains due to bruising, traumatic infiltrates, acute and chronic osteomyelitis, streptoderma, purulent wounds, abscesses.
It is also used in skin plastic surgery - for the engraftment of transplanted skin auto- and homografts, as well as for the preservation of skin homografts.
Contraindication
Hypersensitivity to the drug. Cardiovascular failure, severe atherosclerosis, angina pectoris, impaired renal or hepatic function, stroke, myocardial infarction, comatose states, glaucoma, cataracts.
Interaction with other medicinal products and other types of interactions
Dimethyl sulfoxide enhances the effect of ethanol (alcohol inhibits the excretion of the drug) and insulin, acetylsalicylic acid, butadione; digitalis preparations, quinidine, nitroglycerin, antibiotics (streptomycin, monomycin), chloramphenicol, rifampicin, griseofulvin, sensitizes the body to anesthetics. It should be taken into account that the drug enhances both the specific activity and toxicity of drugs. It can be used together with nonsteroidal anti-inflammatory drugs in the complex therapy of deforming osteoarthritis and rheumatoid arthritis; in combination with local antimicrobial agents (synthomycin liniment) - for the treatment of streptoderma.
Application features
Do not apply to damaged skin or skin with allergic manifestations. Do not apply to facial skin.
Before using the drug, it is necessary to conduct a sensitivity test. To do this, apply Dimexide® Arterium to the skin using a cotton swab moistened with Dimexide® Arterium. Severe redness and itching of the skin after applying Dimexide® Arterium indicate individual hypersensitivity to the drug.
Elderly patients can use the drug after prior consultation with a doctor.
Avoid contact with mucous membranes and eyes. If the product accidentally gets into the eyes, rinse them immediately with running water.
At a temperature of 18 °C, dimethyl sulfoxide may crystallize, which does not affect the quality of the drug. To melt the crystals, carefully heat the bottle with the drug in a water bath (water temperature is about 60 °C).
You should not violate the rules for using the medicine, this may harm your health.
Use during pregnancy or breastfeeding
The drug is contraindicated for use during pregnancy. Breastfeeding should be discontinued during treatment with dimethyl sulfoxide.
Ability to influence reaction speed when driving vehicles or other mechanisms
It should be used with caution, taking into account the effects on the central nervous system, in particular the possibility of dizziness.
Method of administration and doses
Apply in the form of aqueous solutions (30-50% concentration) for compresses and tampons.
Gauze wipes moistened with Dimexide® Arterium solution should be applied to the damaged areas, capturing the adjacent healthy areas of the skin, once a day for 20-30 minutes. Place plastic wrap and cotton or linen cloth on top of the wipe.
For diffuse streptoderma, compresses with a 40-90% solution of the drug Dimexide® Arterium are recommended.
For pustular skin diseases, use a 40% solution.
In dermatoplastic surgery, apply dressings with a 10-20% solution of the drug to transplanted skin auto- and homografts immediately after surgery and in the following days of the postoperative period until the graft is stable.
As a preservative for storing skin homografts, use a 5% solution of the drug in Ringer's solution.
Recommendations for preparing aqueous solutions of the drug of the indicated concentrations:
| Solution concentration, % | Amount of drug, in parts by volume | Amount of water, in parts by volume | 10 20 30 40 50 90 | 1 1 3 2 1 9 | 9 4 7 3 1 1 |
Children.
Do not use the drug in children under 12 years of age.
Overdose
Overdose of the drug may cause allergic reactions (urticaria, edema) and increased manifestations of adverse reactions.
Treatment: Discontinuation of the drug, symptomatic therapy.
Side effects
Dimethyl sulfoxide is usually well tolerated, but some patients may experience:
On the part of the immune system: allergic reactions, including dermatitis, skin rash, angioedema, itching, burning, skin hyperemia, erythema, dry skin.
Gastrointestinal: nausea, vomiting, diarrhea.
From the side of the central and peripheral nervous system: headache, dizziness, insomnia, adynamia.
Respiratory system: bronchospasm.
Expiration date
3 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 ºС.
Keep out of reach of children.
Packaging
50 ml in a bottle; 1 bottle in a pack.
Vacation category
Without a prescription.
Producer
PJSC "Halychpharm".
Address
Ukraine, 79024, Lviv, Opryshkivska St., 6/8.
