Dipyridamole injection solution is used for the following indications: as an antiplatelet agent for the prevention of postoperative thrombosis, cerebral circulation disorders.
Composition
The active substance is dipyridamole (1 ml of solution contains 5 mg of dipyridamole).
Excipients: tartaric acid, propylene glycol, water for injection.
Contraindication
hypersensitivity to the components of the drug; widespread atherosclerosis of the coronary arteries, acute myocardial infarction, decompensated heart failure, arrhythmias, arterial hypotension (collapse), unstable angina, subaortic stenosis, renal failure, bronchial asthma, obstructive pulmonary disease, severe liver failure, hemorrhagic diathesis, diseases with a tendency to bleeding (gastric ulcer and duodenal ulcer).
Method of application
Adults and children over 12 years of age should be administered intramuscularly or slowly intravenously at 1-2 ml of a 0.5% solution per day. The duration of treatment is determined individually and depends on the degree of risk of thromboembolic complications.
Application features
Pregnant women
Do not use the drug during pregnancy.
The drug penetrates into breast milk, therefore breastfeeding should be discontinued during the period of use of the drug.
Children
Do not use in children under 12 years of age.
Drivers
When using the drug, caution should be exercised when driving or operating other machinery.
Overdose
Symptoms: feeling of warmth in the body, redness of the facial skin, increased sweating, irritability, general weakness and dizziness, hypotension, tachycardia, angina attacks.
Treatment: use of adsorbents, symptomatic treatment with vasopressor agents is recommended. The administration of xanthine (e.g. aminophylline) inhibits the vasodilatory effect of dipyridamole.
Due to the fact that dipyridamole has a high degree of protein binding, dialysis is ineffective.
The vasodilator effect of dipyridamole can be reversed by administering aminophylline (50-100 mg over one minute). If angina attacks occur, administer sublingual nitroglycerin.
Side effects
From the cardiovascular system: palpitations, bradycardia, arrhythmia, arterial hypotension, feeling of heat and tachycardia, especially in people taking vasodilators, exacerbation of ischemic heart disease (angina pectoris and arrhythmia), coronary steal syndrome, lowering blood pressure with rapid intravenous administration.
Gastrointestinal tract: nausea, vomiting, diarrhea, epigastric pain, dyspepsia.
On the part of the blood: thrombocytopenia, changes in the functional properties of platelets, bleeding; very rarely, an increased tendency to bleed during or after surgical interventions has been observed.
From the nervous system: headache, weakness, dizziness of vascular origin, loss of consciousness, tremor.
Skin and subcutaneous tissue disorders: allergic reactions, including short-term skin rashes, urticaria.
On the part of the immune system: pronounced bronchospasm and angioedema.
Musculoskeletal system: muscle pain, arthritis, myalgia.
On the part of the digestive system: there have been reports that dipyridamole is a component of gallstones.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C, out of the reach of children.
Shelf life - 3 years.
