Distreptase Distrept suppositories 2g No. 6

Instructions for use Distreptase Distrept suppositories 2g No. 6

Composition

active ingredients: 1 suppository contains streptokinase 15,000 IU, streptodornase 1250 IU;

excipients: mineral oil, solid fat.

Dosage form

Rectal suppositories.

Main physicochemical properties: cone or "torpedo" shape with a pointed end; no mechanical damage, white to cream color.

Pharmacotherapeutic group

Antithrombotic agents. Enzymes. ATC code B01A D.

Pharmacological properties

Pharmacodynamics.

DISTREPTASE Distrept is a combined drug that contains two active substances – streptokinase and streptodornase. Streptokinase is an activator of the proenzyme plasminogen, which is found in human blood and, under the influence of streptokinase, is converted into plasmin, which has the property of dissolving blood clots.

Streptodornase is an enzyme that has the ability to dissolve accumulations of nucleoproteins, dead cells, or pus without affecting living cells and their physiological functions.

The drug facilitates the access of antibiotics or chemotherapeutic agents to the focus of inflammation.

Pharmacokinetics.

Didn't study.

Indication

Treatment of chronic inflammatory processes of the uterine appendages, postoperative infiltrative lesions of the pelvic organs, endometritis, hemorrhoids in acute and chronic course, pararectal abscesses and fistulas with extensive inflammatory infiltrate, purulent caudal cysts.

Contraindication

The medicine should not be used:

in case of hypersensitivity to the active or auxiliary substances included in the medicinal product;

if the patient has fresh scabbed wounds or surgical stitches at the injection site: the medicine should not come into contact with a fresh scabbed wound or a recently applied stitch, as this may lead to loosening of the stitches and subsequent bleeding from the wound;

after bleeding for about 10 days, as this may cause rebleeding;

with medicines containing calcium salts;

with erysipelas;

patients with reduced blood clotting;

with anticoagulants (drugs that reduce blood clotting) due to an increased risk of local bleeding.

Interaction with other medicinal products and other types of interactions

Enhances the penetration of antibiotics and chemotherapeutic drugs into the focus of inflammation. Contraindicated for use with anticoagulants, as bleeding at the injection site is possible.

Application features

Use only as directed by a physician. The drug may cause local irritation. Wash hands thoroughly before and after using suppositories.

Use during pregnancy or breastfeeding

Do not apply.

The ability to influence the reaction speed when driving vehicles or other mechanisms.

No effect.

Method of administration and doses

Adults.

Remove the suppository from the blister pack and insert it deep into the rectum.

The dosage depends on the course and intensity of the inflammatory process.

In severe cases of the disease in adults:

1 suppository 3 times a day for the first 3 days;

1 suppository 2 times a day for the next 3 days;

1 suppository once a day for the next 3 days.

For mild to moderate disease in adults:

1 suppository 2 times a day for the first 3 days;

1 suppository once a day for the next 4 days,

or:

1 suppository 2 times a day for 2 days.

The course of treatment is an average of 8–18 suppositories.

The duration of treatment is on average 7–10 days.

Elderly patients.

There is no information on the need for dosage adjustments in patients over 65 years of age.

Liver dysfunction.

The drug is used in the form of rectal suppositories and is not metabolized in the liver, so there is no need to change the dosage for patients with liver failure.

Kidney dysfunction.

There is no information on the need for dosage modification for patients with renal insufficiency.

Children.

Do not apply.

Overdose

Symptoms of overdose are unknown. Possible exacerbation of adverse reactions. Treatment is symptomatic.

Adverse reactions

Rarely (≥ 1/10,000 to < 1/1,000) allergic reactions, fever, bleeding tendency may occur. Changes at the injection site may occur, including irritation, pain, swelling.

Expiration date

3 years.

Storage conditions

Store at 2 to 8°C. Do not freeze. Keep out of reach of children.

Packaging

6 suppositories in a blister; 1 blister in a cardboard box.

Vacation category

According to the recipe.

Producer

"BIOMED-LUBLIN" Surowitz and Szczepionek Manufacturing Company.

Location of the manufacturer and address of its place of business.

10 Universytetska Street, 20-029 Lublin, Poland.