Pharmacological properties
Ibuprofen, the active ingredient of Dolgit cream, is an NSAID and analgesic for topical use for joint and muscle pain. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect, reduces swelling that occurs with inflammation caused by injuries or rheumatic diseases, improves joint mobility. The pharmacological activity of the drug is due to its ability to inhibit the synthesis of prostaglandins.
When applied externally, ibuprofen is rapidly absorbed through the skin and enters the focus of inflammation. The effect occurs after 30 minutes and lasts for several hours. In joint tissues, therapeutic concentrations do not change for several hours, while in blood plasma the amount of active substance is insignificant, as a result - systemic action is practically absent.
Ibuprofen is biotransformed in the liver and excreted by the kidneys (90%). Comparative studies (oral/topical ibuprofen) have shown that the absorption rate of ibuprofen from the cream is 5%. The metabolism of ibuprofen when applied topically is the same as when applied orally.
C max in blood plasma is reached after 2 hours and after 6 hours in synovial fluid. Ibuprofen is 99% bound to plasma proteins, is rapidly metabolized and excreted in the urine. The plasma elimination time is 1.8-3.5 hours.
Indication
rheumatism; degenerative joint diseases with pain syndrome (arthrosis); inflammatory diseases of the joints and spine; post-traumatic inflammation of tendons, ligaments, muscles and joints (bruises, contusions, sprains) in sports and other injuries; swelling and inflammation of soft tissues near damaged joints (bursitis, tendonitis, tendovaginitis, damage to ligaments and joint capsule); stiffness of shoulder joint movements; myalgia; lumbago; sports and other injuries (contusions, sprains).
Application
The drug is used externally in adults and children over 14 years of age. The cream is applied in a thin layer to the skin in the area of inflammation in strips 4-10 cm long (which corresponds to 2-5 g of cream or 100-250 mg of ibuprofen) and rubbed in easily. The drug is used 3-4 times a day (if necessary, more often).
For large hematomas and edema, a tight bandage can be used at the beginning of treatment.
The cream can be prescribed simultaneously with ibuprofen-based preparations for oral use.
The duration of therapy depends on the degree and nature of the lesion, the clinical effect and is determined by the doctor individually.
In most cases, the treatment period with the drug is 2-3 weeks.
Contraindication
Hypersensitivity to ibuprofen or other components of the drug; ulcerative lesions of the gastrointestinal tract; dermatoses, weeping eczema; open wounds, inflammatory diseases and skin infections; pregnancy and breastfeeding; age up to 14 years; history of asthma, bronchospasm, rhinitis or skin rash when using acetylsalicylic acid or other nonsteroidal anti-inflammatory drugs.
Side effects
Adverse reactions observed with the use of Dolgit cream are listed below by frequency of occurrence: very common (≥1/10), common (≥1/100, 1/10), uncommon (≥1/1000, 1/100), rare (≥1/10,000, 1/1000), very rare (1/10,000), frequency unknown.
Rarely, skin redness, erythema, exanthema, skin irritation, burning sensation, itching may occur; in some cases, contact dermatitis; very rarely, bronchospasm in patients with increased individual sensitivity to ibuprofen.
Very rarely, the active ingredient ibuprofen can cause anaphylaxis, asthma, dyspnea, bullous dermatoses (including epidermal necrolysis and erythema multiforme).
Prolonged use of the cream on large areas of skin may cause systemic effects of ibuprofen.
The drug contains the antimicrobial preservative sodium methylparaben, which may cause allergic hypersensitivity reactions.
The product contains propylene glycol, which may cause skin irritation.
Special instructions
The cream should not be applied to open wounds or mucous membranes. Contact with eyes is not allowed. If skin rashes occur, the use of the cream should be stopped immediately.
Patients with bronchial asthma, hay fever, nasal mucosal hyperplasia, COPD or chronic respiratory infections (especially with symptoms of hay fever) and with hypersensitivity to analgesics and antirheumatic drugs have a higher risk of developing asthmatic attacks (analgesic intolerance), swelling of the mucous membrane (Quincke's edema), skin swelling or urticaria than other patients. The drug should be used in these patients under the supervision of a physician.
The drug should be used with caution in patients with hypersensitivity to other excipients of the drug, which causes skin irritation, itching, urticaria.
You should consult a doctor if discomfort during treatment lasts longer than 3 days.
When using the drug, excessive exposure to sunlight should be avoided due to possible manifestations of photosensitivity.
Should not be used under occlusive dressings.
The drug should be used with caution in patients with concomitant kidney diseases.
Ability to influence the reaction rate when driving vehicles or working with other mechanisms. There is no data on the effect of ibuprofen in gel form on the ability to drive vehicles and work with potentially dangerous machinery.
Children. There is insufficient experience with the use of the drug in children under 14 years of age, so the drug is not used in this age category.
Interactions
So far, no interactions have been identified with external use of the drug.
It is necessary to inform the doctor about the simultaneous use of other drugs or about recent therapy.
Overdose
In case of overdose, side effects may occur that are observed with systemic use of ibuprofen (nausea, heartburn, vomiting, flatulence, skin allergic reactions, headache, dizziness, ag). In this case, it is necessary to stop using the drug. If the recommended dose is exceeded, the cream should be washed off with water. When used in high doses, it is necessary to inform the doctor about this. Treatment is symptomatic.
There is no specific antidote.
Storage conditions
In the original packaging at a temperature not exceeding 25 °C.
