Dolox retard tablets 100 mg No. 20

Dolox Retard tablets are indicated for inflammatory and degenerative forms of rheumatism (rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, spondyloarthritis, pain syndrome of various localization, extra-articular rheumatism), post-traumatic and postoperative pain, inflammatory processes and edema, painful and/or inflammatory conditions in gynecology (for example, primary dysmenorrhea or adnexitis).

Composition

Active ingredient: diclofenac;

1 tablet contains diclofenac sodium 100 mg;

Excipients: magnesium stearate, microcrystalline cellulose, hypromellose; corn starch, colloidal silicon dioxide, talc, lactose monohydrate, Tabcot TC white; dye Yellow sunset FCF (E 110).

Contraindication

Hypersensitivity to the active substance or to any component of the drug; Acute gastric or intestinal ulcer; gastrointestinal bleeding or perforation, history of gastrointestinal bleeding or perforation after taking nonsteroidal anti-inflammatory drugs (NSAIDs), history of acute or recurrent gastric or intestinal ulcer; DOLOX RETARD, like other nonsteroidal anti-inflammatory drugs, is contraindicated in patients who develop asthma attacks, urticaria or acute rhinitis in response to the use of acetylsalicylic acid or other nonsteroidal anti-inflammatory drugs; Inflammatory bowel diseases (Crohn's disease or ulcerative colitis); Severe hepatic insufficiency (Child-Pugh class C, cirrhosis or ascites); Severe renal insufficiency (creatinine clearance <30 ml/min); Congestive heart failure (NYHA II-IV); Coronary heart disease in patients with angina pectoris who have had a myocardial infarction; Cerebrovascular disease in patients who have had a stroke or have episodes of transient ischemic attacks; Peripheral artery disease.

Method of application

The dose should be selected individually, starting with the minimum effective dose, and should be taken for a short period of time.

The recommended initial dose for adults is 100 mg per day (1 tablet of DOLOX RETARD).

Application features

Pregnant women

During the first and second trimesters of pregnancy, DOLOX RETARD should be prescribed only in cases where the expected benefit to the mother outweighs the potential risk to the fetus, and only in the minimum effective dose and for the shortest possible period.

Children

Do not use for the treatment of children due to the high content of the active substance in the tablet.

Drivers

Patients who experience visual disturbances, dizziness, drowsiness, central nervous system disorders, lethargy or fatigue during therapy with DOLOX RETARD are not recommended to drive or operate complex machinery.

Overdose

There is no typical clinical picture for an overdose of DOLOX RETARD. In case of overdose, headache, nausea, epigastric pain, vomiting, gastrointestinal bleeding, diarrhea, dizziness, disorientation, drowsiness, coma, agitation, tinnitus or convulsions may occur. In case of severe poisoning, acute renal failure and liver damage are possible.

Treatment of acute NSAID poisoning consists of supportive and symptomatic therapy.

Side effects

From the blood and lymphatic system: thrombocytopenia, leukopenia, hemolytic anemia, aplastic anemia, agranulocytosis.

Immune system disorders: hypersensitivity, anaphylactic and anaphylactoid reactions (including bronchospasm, hypotension and shock), angioedema (including facial swelling).

Interaction

Concomitant treatment with potassium-sparing diuretics, cyclosporine, tacrolimus or trimethoprim may cause an increase in serum potassium levels, which should be monitored.

Drugs that enhance photosensitivity increase the sensitizing effect of diclofenac against ultraviolet radiation.

Storage conditions

Store in the original packaging at a temperature not exceeding 30 ° C. Keep out of the reach of children.

Shelf life - 3 years.