Enalapril is an angiotensin-converting enzyme inhibitor, monocomponent, for the treatment of arterial hypertension, treatment of clinically significant heart failure, prevention of clinically significant heart failure in patients with asymptomatic left ventricular dysfunction (ejection fraction ≤ 35%).
Warehouse
1 tablet contains enalapril maleate (calculated as 100% substance) - 10 mg; excipients: lactose monohydrate; potato starch; microcrystalline cellulose; povidone; colloidal anhydrous silicon dioxide; talc; calcium stearate.
Contraindication
Hypersensitivity to enalapril, to any of the excipients or to any other ACE inhibitor.
History of angioedema associated with the use of ACE inhibitors.
Hereditary or idiopathic angioedema.
Method of application
Arterial hypertension
The dose of the drug ranges from an initial 5 mg to a maximum of 20 mg, depending on the degree of arterial hypertension and the patient's condition. Enalapril should be taken once a day. For mild arterial hypertension, the recommended initial dose is 5-10 mg.
Heart failure/asymptomatic left ventricular dysfunction
For the treatment of clinically significant heart failure, enalapril should be used together with diuretics and, if necessary, digitalis or β-blockers. The initial dose of Enalapril for patients with clinically significant heart failure or asymptomatic left ventricular dysfunction is 2.5 mg, while the use of the drug should be carried out under careful medical supervision in order to establish the initial effect of the drug on blood pressure.
Application features
In some patients with heart failure with normal or low blood pressure, enalapril may further reduce blood pressure. This reaction to the drug is expected and is usually not a reason to stop treatment. If hypotension becomes resistant to treatment, the dose should be reduced and/or the diuretic and/or enalapril should be discontinued.
Pregnant women
The medicine should not be used by pregnant women or women planning to become pregnant.
Children
Use for children aged 6 and over.
Drivers
When driving or operating other machinery, the possible development of dizziness or increased fatigue should be taken into account.
Overdose
The main signs of overdose, according to available data, are pronounced arterial hypotension, which begins approximately 6 hours after taking the drug and coincides with the blockade of the renin-angiotensin system, and stupor. Symptoms associated with overdose with ACE inhibitors may include circulatory shock, electrolyte imbalance, renal failure, pulmonary hyperventilation, tachycardia, palpitations, bradycardia, dizziness, anxiety and cough.
Side effects
From the blood system: anemia (including aplastic and hemolytic), neutropenia, decreased hemoglobin, decreased hematocrit, thrombocytopenia, agranulocytosis, bone marrow suppression, pancytopenia, lymphadenopathy, autoimmune diseases, leukopenia.
On the part of the endocrine system: syndrome of inappropriate antidiuretic hormone secretion.
Metabolic disorders: hypoglycemia.
From the nervous system and psyche: depression, headache, confusion, drowsiness, insomnia, nervousness, paresthesia, vertigo, sleep disorders, abnormal dreams, dizziness.
On the part of the organs of vision: blurred vision, visual impairment.
Storage conditions
Store in the original packaging at a temperature not exceeding 25°C.
Keep out of reach of children.
