Pharmacological properties
Ergocalciferol (24 - methyl-9,10 - secacholest-5,7,10 (19), 22 - tetran-3b-ol) - a preparation of fat-soluble vitamins D2. Regulates the metabolism of phosphorus and calcium, promotes their absorption in the intestines, distribution in the body, deposition in bones during their growth. The specific effect of the vitamin is especially pronounced in rickets.
Indication
Prevention and treatment of rickets, as well as bone diseases caused by calcium metabolism disorders (various forms of osteoporosis, osteomalacia), parathyroid gland dysfunction (tetany), some forms of tuberculosis, psoriasis, lupus-like lesions of the skin and mucous membranes.
Application
Inside. in the treatment of rickets of the 1st degree in full-term children, the daily dose is 10,000-15,000 IU. for a course of treatment (30-45 days) - 500,000-600,000 IU. in the acute course of the disease, the specified course dose is prescribed for 10 days. the course dose for rickets of the 2nd degree is 600,000-800,000 IU. the course of treatment for this form of the disease is 30-35 days (subacute course) or 10-15 days (acute course). in the case of rickets of the 2nd-3rd degree, repeated anti-relapse treatment is carried out in a course dose of 400,000 IU, which is prescribed for 10 days. for the treatment of rickets of the 3rd degree, the course dose is 800,000-1,000,000 IU. The course of treatment for this form of the disease is 40-60 days (subacute course) or 10-15 days (acute course). Treatment of patients with severe acute rickets (including those with concomitant pneumonia) is carried out only in a hospital, prescribing a dose of 800,000 IU for 3-6 days.
For the prevention of rickets in newborns and infants, ergocalciferol is prescribed to pregnant and breastfeeding women. During pregnancy (term 30-32 weeks), the drug is prescribed in low doses for 10 days (total dose - 400,000-600,000 IU). During breastfeeding, it is prescribed from the first days of feeding in an initial dose of 500 IU / day. For prophylactic purposes, the drug is prescribed to full-term children from the 3rd week of life (for a course of about 300,000 IU). From the 2nd week of life, a total dose of 600,000 IU is prescribed to premature and formula-fed children, twins, children living in adverse environmental, climatic and living conditions. In the prevention of rickets, ergocalciferol is prescribed according to one of the following schemes: "fractional" method - daily 500-1000 IU during the 1st year of life; "vitamin shock" method - 50,000 IU once a week for 8 weeks; "Condensed" method - premature babies and children with frequently occurring intercurrent diseases are prescribed 300,000-400,000 IU of the drug for 10-12 days. After treatment with the drug for a year, ergocalciferol is prescribed to the child until he reaches 2 years of age in the autumn-winter period. In regions with long winters, prophylaxis is continued until he reaches 3 years of age.
The use of the drug in some forms of tuberculosis and psoriasis is carried out in accordance with comprehensive treatment regimens for these diseases.
The daily dose for the prevention of tetany is 1,000,000 IU. For tuberculous lupus in adults - 100,000 IU, for children under 16 years of age - after meals in a dose of 25,000-75,000 IU/day in 2 doses. The course of treatment is 5-6 months.
Contraindication
Gastric and duodenal ulcers, other diseases of the digestive tract, acute and chronic diseases of the liver, kidneys, organic heart diseases, active forms of tuberculosis, hypercalcemia.
Side effects
In case of overdose and use of high doses of the drug, manifestations of hypervitaminosis D are possible - anorexia, nausea, general weakness, headache, sleep disturbances, irritability, hyperthermia, in the urine - leukocyturia, proteinuria, cylindruria; hypercalcemia, hypercalciuria, calcification of soft tissues, lungs, kidneys, blood vessels.
Special instructions
Since ergocalciferol is able to accumulate in the body, the drug is used under the supervision of a physician, including a study of the content of calcium in the blood and urine. It is prescribed with caution to the elderly and pregnant women over the age of 35. When using the drug in high doses, it is necessary to simultaneously prescribe retinol (10,000-15,000 IU / day), ascorbic acid and vitamins of group B.
Interactions
When used simultaneously with calcium salts, the toxicity of vitamin D2 increases. When administered with iodine preparations, oxidation of vitamin D occurs. When combined with antibiotics (tetracycline, neomycin), impaired absorption of ergocalciferol is observed. Combination with inorganic acids leads to inactivation of the drug.
Overdose
See Side Effects.
Storage conditions
In a well-closed container in a dark place at a temperature not exceeding 10 °C.
