Translation of the instructions can be
Escuvit gel 1%
Instruction
For medical use of the medicinal product
Escuven®
Composition:
Active ingredient: aescin;
1 g of gel contains 10 mg of amorphous β-escin;
excipients: carbomer, propylene glycol, triethanolamine, methylparaben (E 218), ethanol 96%, purified water.
Dosage form.
Gel 1%.
Main physicochemical properties: colorless or with a yellowish tinge, slightly opalescent, transparent homogeneous gel.
Pharmacotherapeutic group.
Angioprotectors. Capillary stabilizing agents.
PBX code S05S X03.
Pharmacological properties.
Pharmacodynamics.
Escin is a natural mixture of triterpene saponins obtained from the seeds of horse chestnut (Aesculus hippocastanum L.), which have anti-edematous, venotonic and anti-inflammatory properties. In addition, escin acts at the initial stage of the inflammatory process, associated with increased membrane and capillary permeability and the production of exudate in adjacent tissues.
Aescin exhibits antiserotonin and antihistamine effects.
Escin inhibits the activity of prostaglandin synthetase. This enzyme is necessary for the formation of prostaglandins, which play an important role in the mechanism of inflammation.
Escin prevents the decrease in ATP content in endothelial cells and increases the activity of phospholipase A2, an enzyme responsible for the release of precursors of inflammatory mediators.
Escin reduces the activity of lysosomal enzymes that break down proteoglycans contained in the capillary walls. This increases capillary resistance, reduces their permeability, thereby reducing the amount of exudate and the formation of edema.
Pharmacokinetics.
Didn't study.
Clinical characteristics.
Indication.
Varicose veins, leg swelling and pain associated with venous insufficiency, post-traumatic hematomas and hematomas after injections and infusions.
Contraindication.
Hypersensitivity to the components of the drug, skin damage (e.g., burns, eczema, open wounds).
Interaction with other drugs and other types of interactions.
Unknown. It is not recommended to use the gel on the same area of skin together with other topical agents.
Application features.
Do not apply the gel to inflamed skin, open wounds and mucous membranes. DO NOT rub when applying. If you develop skin inflammation, thrombophlebitis, severe pain, sudden swelling of one or both legs, heart or kidney failure, you should immediately consult a doctor. If you suddenly develop severe symptoms of venous insufficiency (swelling, discoloration of the skin, feeling of tension and pain), especially on one limb, it is necessary to exclude thrombosis of the veins of the lower extremities.
The use of the gel for varicose veins does not replace other preventive or therapeutic measures (e.g., wearing supportive elastic stockings, dousing with cold water).
Avoid contact with eyes and mucous membranes. Wash hands thoroughly after each application of the gel.
The gel contains methylparaben (E 218), which may cause an allergic reaction (including a delayed one), and in exceptional cases - bronchospasm, and propylene glycol (E 1520), which can cause skin irritation.
Use during pregnancy or breastfeeding.
Due to the lack of relevant data, escuven® gel should not be used during pregnancy and breastfeeding.
The ability to influence the reaction speed when driving vehicles or other mechanisms.
Does not affect.
Method of administration and doses.
Apply a thin layer of the gel to the damaged area of skin and around it 2-3 times a day. Do not rub in.
For varicose veins, the simultaneous use of an elastic bandage or elastic stockings is recommended.
The duration of treatment depends on the severity of the therapeutic effect. If after 14 days of therapy there is no improvement, you should consult a doctor.
Children.
There is insufficient experience with the drug in children, so it is not recommended for use in patients of this age group.
Overdose.
There are no data on overdose.
Adverse reactions.
Hypersensitivity reactions, including dermatitis, including allergic, skin rash, itching, erythema, burning sensation of the skin, bronchospasm, are possible. In case of such reactions, it is necessary to stop using the drug and consult a doctor.
Expiration date.
3 years.
Storage conditions.
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging.
30 g or 50 g in tubes.
Vacation category.
Without a prescription.
Manufacturer/applicant.
"Ternofarm" LLC.
Location of the manufacturer and address of its place of business.
"Ternofarm" LLC.
Ukraine, 46010, Ternopil, Fabrychna St., 4.
Tel. / Fax: (0352) 521-444, http://www.ternopharm.com.ua
