Instructions for Espol ointment for external use, tube 30 g
Composition
active ingredients: capsicum extract thick, dimethyl sulfoxide;
1 g of ointment contains: thick capsicum extract (Extractum Capsici annui spissum) – 100 mg, (5.55:1) (extractant – ethanol 80%), calculated as the sum of capsaicinoids – 1 mg; dimethyl sulfoxide – 30 mg;
excipients: coriander oil, lavender oil, chloroform, lanolin, white soft paraffin, yellow soft paraffin.
Dosage form
Ointment.
Main physicochemical properties: ointment from light brown to reddish brown in color, of uniform consistency with a faint specific odor.
Pharmacotherapeutic group
Remedies used topically for joint and muscle pain. Capsicum preparations and similar remedies.
ATX code M02A B.
Pharmacological properties
Pharmacodynamics
Espol has an analgesic, distracting, warming, resorbable, anti-inflammatory and local irritating effect. The therapeutic effect is due to the complex action of the components that make up the drug. Capsaicins of capsicum extract have a strong local irritating effect on sensitive skin receptors; dimethyl sulfoxide has an analgesic and anti-inflammatory effect, exhibits moderate fibrinolytic activity, the drug enhances the penetration of drugs through intact skin and mucous membranes, promotes deeper penetration of the medicinal substance used with it; coriander oil has a general strengthening and toning effect; lavender oil exhibits mild sedative and antispasmodic properties. The components of the ointment cause reflex dilation of small vessels and improve blood supply to the pain site, as a result of which the drainage of this area is enhanced and the products of inflammation are removed.
Pharmacokinetics
The effect is observed 10–15 minutes after application of the drug and reaches a maximum after 30 minutes. The duration of anesthesia is from 30 minutes to 2 hours.
Indication
Myositis, injuries without violation of the integrity of the skin, muscle sprains and tears, neuralgia, lumbago, lumbosacral radiculitis, fractures.
Contraindication
Hypersensitivity to the components of the drug, bronchial asthma, renal failure, hepatic failure, cardiovascular failure, circulatory failure, glaucoma, cataracts, severe atherosclerosis, angina pectoris, stroke, myocardial infarction, comatose states, pregnancy, breastfeeding period, children under 12 years of age, injuries, impaired skin integrity, open wounds, eczema, active stage of any inflammatory process, purulent skin diseases.
Interaction with other medicinal products and other types of interactions
Dimethyl sulfoxide, which is part of the drug, enhances the effect of ethanol (alcohol inhibits the excretion of the drug) and insulin, acetylsalicylic acid, butadione; digitalis preparations, quinidine, nitroglycerin, antibiotics (streptomycin, monomycin, etc.), chloramphenicol, rifampicin, griseofulvin, sensitizes the body to anesthetics. It should be taken into account that the drug enhances both the specific activity and toxicity of drugs. It can be used together with nonsteroidal anti-inflammatory drugs in the complex therapy of deforming arthrosis and rheumatoid arthritis; in combination with topical antimicrobial agents (synthomycin liniment) - for the treatment of streptoderma.
Do not use the ointment simultaneously with other locally irritating medications, agents that increase blood supply and cause skin redness.
Increases the likelihood of neuropathy when using drugs containing sulindac.
Simultaneous use with analgesic gels is not recommended.
Interaction with other medications applied to the same area is possible even within 12 hours after removing the ointment.
If you are taking any other medications at the same time, you should inform your doctor.
Application features
Do not allow the ointment to get on damaged skin, eyes, or mucous membranes.
Applying bandages is possible only after most of the ointment has been absorbed.
Additional heat sources should be avoided during treatment (e.g. solar or infrared radiation, heating pad or warm water). The effect of heat can also be enhanced by physical activity (increased sweating).
If excessive thermal effect is observed, treatment should be discontinued. In this case, excess ointment should be removed.
If symptoms worsen while using Espol ointment, you should consult a doctor.
Ability to influence reaction speed when driving vehicles or other mechanisms
It should be used with caution, taking into account the effects on the central nervous system, in particular the possibility of dizziness.
Use during pregnancy or breastfeeding
Do not use during pregnancy or breastfeeding.
Method of administration and doses
Apply a 4–7 cm long column of ointment (2–3 g of ointment) in a thin layer to a palm-sized area of skin using light rubbing movements, avoiding contact with damaged skin or wounds, 2–3 times a day.
The duration of use, which is determined individually by the doctor, usually ranges from 1 to 10 days. After applying the ointment, wash your hands thoroughly. After the procedure, remove any ointment remaining on the skin with a cloth dampened with soapy water.
Children
Use for children over 12 years of age.
Overdose
The appearance of allergic reactions, including skin rashes, hives, peeling skin.
Treatment: after signs of overdose appear, remove the ointment remaining on the skin with a cloth moistened with soapy water and consult a doctor. Therapy is symptomatic.
Adverse reactions
Skin: dermatitis, skin rash, itching, peeling of the skin at the site of application, skin hyperemia, erythema, sensation of warmth and burning at the site of ointment application, tingling, contact eczema.
Hypersensitivity reactions: angioedema, bronchospasm, hypersensitivity, allergic reactions including urticaria, blistering.
From the side of the central nervous system: dizziness, headache, insomnia, adynamia.
From the digestive tract: nausea, vomiting.
These phenomena quickly disappear after discontinuation of the drug. In case of any adverse reactions, the drug should be discontinued and a doctor should be consulted.
Expiration date
3 years.
Do not use after the expiry date stated on the packaging.
Storage conditions
Store in the original packaging at a temperature not exceeding 25°C.
Keep out of reach of children.
Packaging
30 g in tubes.
1 tube in a cardboard pack.
Vacation category
Without a prescription.
Producer
PJSC "Chempharmaceutical Plant "Chervona Zirka".
Location of the manufacturer and its business address
61010, Ukraine, Kharkiv, 1 Hordienkivska St.
