Translation of the instructions can be
GLUCOSE solution for infusion 50 mg/ml
Instruction
For medical use of the medicinal product
Composition:
Active ingredient: glucose;
1 ml of solution contains glucose monohydrate in terms of anhydrous glucose 50 mg;
excipient: water for injections.
Dosage form.
Solution for infusion.
Main physicochemical properties: clear, colorless or slightly yellowish liquid.
Pharmacotherapeutic group.
Blood substitutes and perfusion solutions. ATS code B05C X01.
Pharmacological properties.
Pharmacodynamics.
Glucose solution 5% isotonic with respect to blood plasma and when administered intravenously replenishes the volume of circulating blood, when it is lost it is a source of nutrients, and also helps to remove poison from the body. Glucose provides substrate replenishment of energy expenditure. When injected intravenously, it activates metabolic processes, improves the antitoxic function of the liver, enhances myocardial contractile activity, dilates blood vessels, and increases diuresis.
Pharmacokinetics.
After administration, it is rapidly distributed in body tissues. It is excreted by the kidneys.
Clinical characteristics.
Indication.
Hyper- and isotonic dehydration; in children to prevent water-electrolyte balance disorders during surgical interventions; intoxication; hypoglycemia; as a solvent for other compatible drug solutions.
Contraindication.
Glucose solution is contraindicated in patients with:
hyperglycemia; hypersensitivity to glucose.
The drug should not be administered simultaneously with blood products.
Interaction with other drugs and other types of interactions.
When used simultaneously with thiazide diuretics and furosemide, their ability to affect the level of glucose in the blood serum should be taken into account. Insulin promotes the entry of glucose into peripheral tissues. Glucose solution reduces the toxic effect of pyrazinamide on the liver. The introduction of a large volume of glucose solution contributes to the development of hypokalemia, which increases the toxicity of simultaneously used drugs for digitalis. Glucose is incompatible in solutions with aminophylline, soluble barbiturates, hydrocortisone, kanamycin, soluble sulfonamides, cyanocobalamin.
Application features.
The drug should be used with great caution in patients with intracranial and intraspinal hemorrhages.
With prolonged intravenous use of the drug, blood sugar levels must be monitored.
In order to prevent the occurrence of plasma hypoosmolarity, 5% Glucose solution can be combined with the administration of isotonic sodium chloride solution.
When administering large doses, if necessary, insulin is administered subcutaneously at the rate of 1 U per 4-5 g of glucose.
The contents of the vial may be used for one patient only. Once the seal of the bottle or polyethylene vial is broken, any unused portion of the contents of the bottle or vial should be discarded.
Use during pregnancy or breastfeeding.
The drug can be used according to indications.
The ability to influence the reaction speed when driving vehicles or other mechanisms.
Data are missing due to the exclusive use of the drug in a hospital setting.
Method of administration and doses.
The drug is administered intravenously drip. The dose for adults is up to 1500 ml per day. The maximum daily dose for adults is 2000 ml. If necessary, the maximum rate of administration for adults is 150 drops per minute (500 ml / h).
Children.
For children, the dose depends on age, body weight, condition, and laboratory parameters.
Overdose.
Increased manifestations of adverse reactions.
Hyperglycemia and hypotonic hyperhydration may develop. In case of overdose, symptomatic treatment and administration of regular insulin preparations are prescribed.
Adverse reactions.
Electrolyte balance disorders and general body reactions that occur during massive infusions:
hypokalemia; hypophosphatemia; hypomagnesemia; hyponatremia; hypervolemia; hyperglycemia; allergic reactions (hyperthermia, skin rashes, angioedema, shock).
Gastrointestinal tract: very rarely - nausea of central origin.
In case of adverse reactions, the administration of the solution should be stopped, the patient's condition should be assessed and appropriate assistance should be provided.
Expiration date.
3 years.
Storage conditions.
Store in the original packaging at a temperature not exceeding 25 ºС.
Keep out of reach of children.
Incompatibility.
Glucose is incompatible in solutions with aminophylline, soluble barbiturates, erythromycin, hydrocortisone, warfarin, kanamycin, soluble sulfonamides, and cyanocobalamin.
Do not use in the same system simultaneously, before or after blood transfusion due to the possibility of pseudoagglutination.
Packaging.
200 ml in bottles.
Vacation category.
According to the recipe.
Producer.
1. LLC Novopharm-Biosynthesis.
2. PJSC "Halychpharm".
Location of the manufacturer and address of the place of business.
1. Ukraine, 11700, Zhytomyr region, Novohrad-Volynskyi city, Zhytomyrska st., 38.
2. Ukraine, 79024, Lviv, Opryshkivska St., 6/8.
Applicant.
PJSC "Halychpharm".
Location of the applicant.
Ukraine, 79024, Lviv, Opryshkivska St., 6/8.
