Glutamic acid film-coated tablets 0.25 g blister No. 10

Pharmacological properties

Pharmacodynamics. a non-essential amino acid that participates in the processes of amino acid transamination in the body, in protein and carbohydrate metabolism, stimulates oxidative processes, promotes the neutralization and excretion of ammonia from the body, increases the body's resistance to hypoxia. promotes the synthesis of acetylcholine and ATP, the transfer of potassium ions, plays an important role in the activity of skeletal muscles. glutamic acid refers to neurotransmitter amino acids that stimulate the transmission of excitation in the synapses of the central nervous system.

Pharmacokinetics. Glutamic acid is well absorbed when taken orally. It is rapidly eliminated from the blood, accumulating mainly in muscle and nervous tissues, in the liver and kidneys, penetrates the blood-brain barrier and cell membranes. Partially, glutamic acid is reaminated during absorption to form alanine. Under the influence of the enzyme glutamate decarboxylase, it is converted in the brain into a mediator - gamma-aminobutyric acid. About 4-7% of it is excreted in the urine unchanged, the rest is utilized in the process of metabolic transformations.

Indication

Epilepsy, mainly minor seizures with equivalents, somatogenic, involutional, intoxication psychoses, reactive states with depressive phenomena, exhaustion, mental retardation in children, Down syndrome, cerebral palsy, poliomyelitis (acute and convalescent periods), progressive myopathy (as part of combination therapy), to eliminate and prevent neurotoxic effects caused by isonicotinic acid hydrazide preparations.

Application

Adults are prescribed a dose of 1 g 2-3 times a day. Single doses for children are: at the age of 3-6 years - 250 mg, 7-9 years - 0.5-1 g; 10 years and older - 1 g, the frequency of administration is 2-3 times a day.

In oligophrenia, 100-200 mg/kg of the patient's body weight for several months. Take 15-30 minutes before meals, with the development of dyspeptic phenomena - during or after meals. The course of treatment is from 1-2 to 6-12 months.

Contraindication

Feverish conditions, increased excitability, pronounced psychotic reactions, hepatic and/or renal failure, nephrotic syndrome, gastric and duodenal ulcers, diseases of the blood-forming organs, anemia, leukopenia.

Side effects

Blood and lymphatic system disorders: decreased hemoglobin level, leukopenia.

Gastrointestinal tract: vomiting, diarrhea.

From the nervous system: headache, increased irritability, insomnia.

On the part of the immune system: allergic reactions, including skin rash, itching, redness.

Special instructions

During treatment, it is necessary to systematically conduct urine and blood tests. If side effects occur, it is recommended to reduce the dose of the drug. Glutamic acid is also used to eliminate neurotoxic phenomena associated with the use of other drugs.

After taking glutamic acid, rinse your mouth with a weak solution of sodium bicarbonate. The drug contains sugar, which should be taken into account by diabetics.

Use during pregnancy and breastfeeding. This medicine should not be used during pregnancy or breastfeeding.

Children. The drug is not used in children under 3 years of age.

Ability to influence the reaction rate when driving vehicles or operating other mechanisms. Given the possible effect of the drug on the nervous system, the drug should be used with caution when driving vehicles or operating other mechanisms.

Interactions

In combination with thiamine and pyridoxine, glutamic acid is used to prevent and treat neurotoxic phenomena caused by isonicotinic acid hydrazide drugs (isoniazid, ftivazid, etc.). In myopia and muscular dystrophy, glutamic acid is more effective in combination with pachycarpine or glycocol.

Overdose

Possible increased manifestations of adverse reactions.

Treatment: symptomatic therapy, gastric lavage, use of enterosorbents.

Storage conditions

At a temperature not exceeding 25 °C.