Instructions Glutargin Alkoklin powder for oral solution 1 g/3 g package 3 g No. 10
Composition
active ingredient: 1 packet (3 g) contains arginine glutamate 1 g;
excipients: glycine, mannitol (E 421), citric acid anhydrous, aspartame (E 951); "Lemon" flavoring containing maltodextrin, gum arabic, citric acid.
Dosage form
Powder for oral solution.
Main physicochemical properties: white to white with a yellowish tinge powder with a fruity odor.
Pharmacotherapeutic group
Drugs used in liver diseases, lipotropic substances. Arginine glutamate. ATX code A05B A01.
Pharmacological properties
Pharmacodynamics
Glutargin Alkoklin is a salt of arginine and glutamic acid.
In case of alcohol intoxication, the drug stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme for ethanol utilization - alcohol dehydrogenase; accelerates the inactivation and excretion of toxic products of ethanol metabolism as a result of increased formation and oxidation of succinic acid; reduces the inhibitory effect of alcohol on the central nervous system (CNS) due to the neurotransmitter properties of excitatory glutamic acid. Due to these properties, the drug exhibits antitoxic and sobering effects.
The drug also has hepatoprotective and hypoammonemic properties. The hepatoprotective effect of the drug is due to its antioxidant, antihypoxic and membrane-stabilizing properties, as well as a positive effect on the processes of energy supply in hepatocytes. The hypoammonemic effects of the drug are realized by activating the neutralization of ammonia in the ornithine cycle of urea synthesis, binding ammonia to non-toxic glutamine, as well as enhancing the removal of ammonia from the CNS and its excretion from the body. Due to these properties of the drug, the general toxic, including neurotoxic effects of ammonia are reduced.
In experimental studies on animals, the drug did not show embryotoxic, gonadotoxic, mutagenic and teratogenic effects, and did not cause allergic and immunotoxic reactions.
Pharmacokinetics
Not investigated.
Indication
Prevention of intoxication and hepatotoxic effects of alcohol. Treatment of acute alcohol intoxication of mild and moderate severity, as well as as part of complex therapy of post-intoxication disorders after acute alcohol poisoning of severe severity.
Contraindication
Hypersensitivity to the components of the drug. Feverish state, increased excitability, severe impairment of filtration (nitrogen excretion) function of the kidneys.
Interaction with other medicinal products and other types of interactions
The effect of the drug on insulin secretion is enhanced by simultaneous administration of aminophylline. The drug may enhance the effect of antiplatelet agents (dipyridamole). Prevents and attenuates neurotoxic phenomena that may occur with the use of isoniazid. Weakens the effect of vinblastine.
Application features
When prescribing the drug to patients with endocrine gland dysfunction, it should be taken into account that the drug stimulates the secretion of insulin and growth hormone. The drug activates the binding of ammonia into urea, which may naturally be accompanied by a short-term increase in its level in the blood.
Aspartame is a derivative of phenylalanine, which is dangerous for people with phenylketonuria.
Use during pregnancy or breastfeeding
Experience with use during pregnancy or breastfeeding is insufficient, therefore the drug should not be used during pregnancy. If use of the drug is necessary, breastfeeding should be discontinued.
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Method of administration and doses
The drug should be administered orally to adults, after dissolving the contents of the packet in ¼-½ cup of water.
To prevent intoxication and hepatotoxic effects of alcohol, take 2 g (2 packets) 1-2 hours before drinking alcohol or 1 g (1 packet) 1 hour before drinking alcohol and 1 g (1 packet) within 0.5 hour after drinking alcohol.
For the treatment of acute alcohol intoxication of mild and moderate severity, take 1 g (1 packet) 4 times a day with intervals of 1-2.5 hours, in the next 2-3 days - 1 g (1 packet) 2 times a day. For severe alcohol intoxication, take 1 g (1 packet) 2 times a day for 20 days as part of complex therapy after a course of treatment with Glutargin injections.
Children
The efficacy and safety of the drug in children have not been studied, so the drug should not be used in this age group of patients.
Overdose
Symptoms: nausea, vomiting, abdominal pain, loose stools, chills, short-term hyperthermia and/or hypotension, CNS excitation, insomnia, chest pain, atrioventricular block.
Treatment. Symptomatic therapy. Depending on the severity of clinical symptoms, activated charcoal is administered, if necessary, antihistamine therapy, intravenous administration of corticosteroids.
Adverse reactions
Occasionally possible:
from the digestive tract: a feeling of mild discomfort in the gastrointestinal tract and nausea immediately after using the drug, which resolve on their own;
Immune system: hypersensitivity reactions, including skin rashes, itching, flushing, urticaria, angioedema.
Expiration date
2 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 ºС.
Keep out of reach of children.
Packaging
3 g in bags No. 1×2, No. 1×5, No. 1×10 or in paired bags No. 2×5 in a box.
Vacation category
Without a prescription.
Producer
Limited Liability Company "Pharmaceutical Company "Zdorovya".
Location of the manufacturer and its business address
Ukraine, 61013, Kharkiv region, Kharkiv city, Shevchenko street, building 22.
