Instructions Glutargin tablets 0.75 g blister No. 30
Composition
active ingredient: arginine glutamate;
1 tablet contains 250 mg (0.25 g) or 750 mg (0.75 g) of arginine glutamate;
excipients: dosage 250 mg – microcrystalline cellulose, crospovidone, croscarmellose sodium, calcium stearate; dosage 750 mg – microcrystalline cellulose, crospovidone, calcium stearate.
Dosage form
Pills.
Main physicochemical properties: 250 mg dosage – white tablets, with a flat surface, with a score and a bevel; 750 mg dosage – white tablets, elongated in shape with a biconvex surface, with a score.
Pharmacotherapeutic group
Drugs used in liver diseases, lipotropic substances. Hepatotropic drugs. Arginine glutamate. ATX code A05B A01.
Pharmacological properties
Pharmacodynamics. Glutargin is a salt of arginine and glutamic acid, which play an important role in ensuring the biochemical processes of neutralization and excretion of the highly toxic metabolite of nitrogenous metabolism - ammonia. The hypoammonemic effects of the drug are realized by activating the neutralization of ammonia in the ornithine cycle of urea synthesis, binding ammonia to non-toxic glutamine, as well as enhancing the removal of ammonia from the central nervous system and its excretion from the body. Due to these properties of Glutargin, the general toxic, including neurotoxic effects of ammonia are reduced.
Glutargin does not exhibit embryotoxic, gonadotoxic, mutagenic and teratogenic effects, and does not cause allergic and immunotoxic reactions.
Pharmacokinetics: Not studied.
Indication
As part of the complex therapy of acute and chronic hepatitis of various etiologies, including poisoning with hepatotropic poisons (pale toadstool, chemicals and medicinal substances), and cirrhosis of the liver.
Hepatic encephalopathy accompanied by hyperammonemia.
Acute alcohol poisoning of mild and moderate severity, hangover syndrome, post-intoxication disorders caused by alcohol intake.
Complications in the third trimester of pregnancy: late gestosis, including its severe forms - preeclampsia and eclampsia, fetoplacental insufficiency, chronic pathologies of the hepatobiliary system in pregnant women.
Contraindication
Hypersensitivity to the components of the drug. Fever, increased excitability, severe violations of the filtration (nitrogen excretion) function of the kidneys.
Interaction with other medicinal products and other types of interactions
The effect of Glutargin on insulin secretion is enhanced by the simultaneous use of aminophylline. Glutargin may enhance the effect of antiaggregants (dipyridamole). Prevents and attenuates neurotoxic phenomena that may occur with the use of isoniazid. Weakens the effect of vinblastine.
Application features
When prescribing to patients with endocrine gland dysfunction, it should be taken into account that the drug stimulates the secretion of insulin and growth hormone. The drug activates the binding of ammonia into urea, which may naturally be accompanied by a short-term increase in its level in the blood.
Use during pregnancy or breastfeeding
The safety of clinical use of the drug in the I and II trimesters of pregnancy and during breastfeeding has not been studied. If necessary, use of the drug should be discontinued breastfeeding.
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Method of administration and doses
The drug is prescribed to adults orally.
Hepatitis, hyperammonemia. Prescribe 750 mg (3 tablets of 250 mg or 1 tablet of 750 mg) 3 times a day for 15 days, regardless of meals. If necessary, the dose of the drug and the course of treatment can be increased to 20 days. The highest single dose is 2 g, the highest daily dose is 8 g.
Alcohol poisoning. Prescribe 1 g (4 tablets of 250 mg) 4 times a day with intervals of 1–2.5 hours, in the next 2–3 days - 500 mg (2 tablets of 250 mg) 3 times a day. In case of severe alcohol poisoning after a course of treatment with Glutargin injections, prescribe Glutargin tablets at a dose of 750 mg (3 tablets of 250 mg or 1 tablet of 750 mg) 2 times a day for 20 days. For the prevention of alcohol intoxication - 2 g 60–120 minutes before drinking alcohol.
Pregnancy pathologies (III trimester). Prescribe 250–500 mg (1–2 tablets of 250 mg) 2–3 times a day for 10–15 days. If necessary, a single dose of the drug can be increased to 750 mg (3 tablets of 250 mg or 1 tablet of 750 mg), the course of treatment is up to 20 days. The highest single dose is 750 mg, the highest daily dose is 2.25 g.
Children. The efficacy and safety of the drug in children have not been studied, so the drug should not be used in this age group of patients.
Overdose
Symptoms: increased manifestations of adverse reactions; possible characteristic manifestations of the action of glutamic acid: chest pain, atrioventricular block.
Treatment: intravenous administration of corticosteroids.
Adverse reactions
On the part of the digestive tract: nausea, epigastric pain, immediately after taking the drug, which resolve on their own.
Immune system disorders: hypersensitivity reactions, including skin rash, itching, flushing, urticaria, angioedema.
Expiration date
5 years.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
250 mg tablets No. 10×3, No. 10×6 in blisters in a box or 750 mg tablets No. 10×3, No. 10×5 in blisters in a box.
Vacation category
Without a prescription.
Producer
Limited Liability Company "Pharmaceutical Company "Zdorovya".
Location of the manufacturer and address of its place of business.
Ukraine, 61013, Kharkiv region, Kharkiv city, Shevchenko street, building 22.
