Composition of the medicinal product:
active ingredients: heparin sodium;
dimethindene maleate, phenylephrine hydrochloride;
1 ml of the drug contains 0.25 mg of dimethindene maleate, phenylephrine hydrochloride equivalent to 2.5 mg of phenylephrine;
Excipients: citric acid, monohydrate; sodium hydrogen phosphate anhydrous; sorbitol (E 420); benzalkonium chloride; peppermint oil, purified water.
Dosage form.
Nasal drops.
Transparent solution from colorless to slightly yellowish color with a specific odor. Opalescence is allowed.
Name and location of the manufacturer.
LLC "Pharmaceutical Company" Zdorovya ".
Ukraine, 61013, Kharkiv, Shevchenko St., 22.
Pharmacotherapeutic group.
Anti-edematous agents for topical use in nasal diseases. ATS code R01A B01.
Grippocitron Rhinos is a combination drug containing phenylephrine and dimethindene.
The drug reduces nasal discharge and helps cleanse the nasal passages, without disrupting the physiological functions of the ciliated epithelium and nasal mucosa.
Phenylephrine belongs to sympathomimetic amines. It is used as a nasal decongestant with a moderate vasoconstrictor effect, selectively stimulating alpha-adrenergic receptors of the cavernous venous tissue of the nasal mucosa. Thus, it quickly and permanently eliminates swelling of the nasal mucosa and its paranasal sinuses.
Dimetinden - an antagonist of histamine H1 receptors - has an antiallergic effect.
Effective when used in low doses, well tolerated.
Grippocitron Rhinos is applied topically, so its activity does not correlate with the concentration of active substances in blood plasma.
With accidental oral absorption, the bioavailability of phenylephrine decreases and is approximately 38%, the half-life is about 2.5 hours.
The systemic bioavailability of dimethindene after oral administration in solution is about 70%, the half-life is about 6 hours.
Indications for use.
Symptomatic treatment of colds, nasal congestion, acute and chronic rhinitis; seasonal (hay fever) and non-seasonal allergic rhinitis, acute and chronic sinusitis, vasomotor rhinitis. Adjunctive therapy in acute otitis media.
Preparation for surgical intervention in the nasal area and elimination of edema of the nasal mucosa and paranasal sinuses after surgical intervention.
Contraindication.
Hypersensitivity to any component of the drug.
Due to the content of phenylephrine, the drug, like other vasoconstrictors, is contraindicated in atrophic rhinitis, as well as in patients taking MAO inhibitors or who have taken them within the previous 14 days.
The drug is not recommended for use during pregnancy and breastfeeding.
Special precautions.
Grippocitron Rhinos should not be used for longer than 1 week. Prolonged or excessive use of the drug may cause tachyphylaxis and the "ricochet" effect (rhinitis medicamentosa).
As with other vasoconstrictors, the recommended dose should not be exceeded. Excessive use of the drug, especially in children and the elderly, may cause systemic effects of the drug.
The drug should be prescribed with caution to patients with cardiovascular diseases, hypertension, thyroid diseases, and angle-closure glaucoma.
Use during pregnancy or breastfeeding. The drug is not prescribed during pregnancy and breastfeeding.
The ability to influence the reaction speed when driving vehicles or working with other mechanisms. Does not affect.
Children. Children under 1 year of age are recommended to use Grippocitron Rhinos drops only as prescribed by a doctor.
Method of administration and doses.
Before administering the drug, the nose should be thoroughly cleaned.
Children under 1 year of age (as prescribed by a doctor)
1 drop in each nostril 3-4 times a day.
Children aged 1 to 6 years
1 or 2 drops in each nostril 3-4 times a day.
Adults and children aged 6 years and over
3 or 4 drops in each nostril 3-4 times a day.
The duration of treatment should not exceed 7 days and depends on the severity of the disease.
Overdose.
No serious side effects have been reported when the drug was accidentally swallowed by young children.
Most cases were asymptomatic, very rarely reported feelings of fatigue, stomach pain, mild tachycardia, increased blood pressure, agitation, insomnia, pallor of the skin.
Treatment: Use activated charcoal, possibly laxatives in young children (gastric lavage is not required); adults and children are prescribed large amounts of fluids to drink.
Side effects.
The drug is usually well tolerated.
In some cases, mild and transient local reactions on the nasal mucosa (burning sensation or dryness) are possible.
Very rare: development of allergic reactions (including local skin reactions, itching of the body, swelling of the eyelids, face, general weakness).
Interaction with other drugs and other types of interactions.
The drug is contraindicated in patients who are taking MAO inhibitors or have taken them within the previous 14 days.
Vasoconstrictors should be prescribed with caution to patients taking tricyclic antidepressants and antihypertensive drugs such as β-blockers.
Storage conditions.
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging.
Nasal drops, 15 ml, in bottles sealed with dropper caps with a threaded neck and a glass pipette in a box.
Vacation category.
Without a prescription.
