Instructions Hepatrombin cream 50000 IU/100 g tube 40 g
Composition
active ingredient: heparin sodium;
100 g of cream contain heparin sodium 30,000 IU or 50,000 IU;
excipients: allantoin, dexpanthenol, disodium edetate, bronopol, hostafate
KW-340-N, lunatsera M, carbomer 934, levomenthol, light mineral oil, glycerol monostearate, isopropyl myristate, white soft paraffin, triethanolamine, purified water.
Dosage form
Cream.
Main physicochemical properties: white homogeneous cream with a characteristic menthol odor.
Pharmacotherapeutic group
Agents used for varicose veins. Heparin or heparinoids for topical use. ATX code C05B A03.
Pharmacological properties
Pharmacodynamics
Hepatrombin cream is a high-dose heparin direct-acting anticoagulant preparation for external use. It has local antithrombotic, anti-edema and anti-inflammatory effects, stimulates metabolic processes in tissues, as well as granulation and epithelialization of tissues, and improves local blood flow.
Pharmacokinetics
When applied externally, heparin does not have a systemic effect, quickly penetrates the skin and accumulates in the stratum corneum of the epidermis, and accordingly, has an exclusively local effect.
Indication
Treatment of superficial vein diseases such as varicose veins and related complications; phlebothrombosis, thrombophlebitis, superficial periphlebitis. Postoperative varicose phlebitis, complications after surgical removal of the saphenous veins of the lower extremities. Injuries and bruises, infiltrates and localized edema, subcutaneous hematomas. Injuries and sprains of musculo-tendon and capsulo-ligamentous structures.
Contraindication
Hypersensitivity to heparin or any other component of the drug; bleeding trophic leg ulcers; open and/or infected wounds, hemorrhagic diathesis; purpura; thrombocytopenia; hemophilia. Bleeding tendency.
Interaction with other medicinal products and other types of interactions
Hepatrombin should not be used together with topical medications, for example, with drugs containing tetracycline, hydrocortisone, salicylic acid, anticoagulants.
The use of heparin may contribute to prolongation of prothrombin time in patients taking oral anticoagulants.
Application features
The cream should be applied only to intact skin. The drug should not be prescribed for bleeding, applied to infected areas of the skin in the presence of purulent processes, mucous membranes. If the patient has hemorrhagic symptoms, the possibility of using the drug should be carefully considered.
The cream should not be applied to wet skin, wounds, ulcers and blisters, eyes and areas around the eyes. In case of accidental ingestion of the cream, the child may experience nausea or vomiting. In this case, gastric lavage should be performed. Treatment is symptomatic.
In case of blood clotting disorders, the cream is not recommended to be applied to large areas of skin.
Use during pregnancy or breastfeeding
During pregnancy or breastfeeding, the drug can only be used for a short time under justified indications, if the expected positive effect for the mother outweighs the potential risk to the fetus or child.
Ability to influence reaction speed when driving vehicles or other mechanisms
Hepatrombin cream does not affect the ability to influence the reaction rate when driving vehicles or working with other mechanisms.
Method of administration and doses
Apply topically.
Treatment should be initiated with a dose of 50,000 IU/100 g, while a dose of 30,000 IU/100 g should be used for continued treatment.
Apply a layer of cream about 1 mm thick to and around the affected area 1-3 times a day and rub it lightly into the skin.
For vein diseases, a venous bandage can be applied.
In the case of treating phlebitis, this medicine does not need to be rubbed into the skin, but only applied to the affected area in a layer about 1 mm thick and bandaged with an elastic bandage.
The duration of the course of treatment is determined by the doctor individually depending on the course of the disease.
Children: Due to limited experience, the drug should not be prescribed to children.
Overdose
Due to the low systemic absorption of the drug, there is no risk of overdose when applied topically. In case of accidental internal use, nausea and vomiting may occur. Gastric lavage is necessary, and further treatment is symptomatic.
The effect of heparin can be neutralized with protamine sulfate.
Adverse reactions
During the course of treatment, a hypersensitivity reaction to some of the ingredients of the drug may develop. Signs of such hypersensitivity include itching, redness, swelling of the skin, burning sensation, skin rashes, urticaria, angioedema, hemorrhages, sometimes the appearance of small pustules, blisters or blisters. When applied to large areas of the skin, systemic adverse reactions are possible.
Expiration date
3 years.
Storage conditions
Store at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
40 g in a tube; 1 tube in a cardboard box.
Vacation category
Without a prescription.
Producer
"Hemofarm" AD/"Hemofarm" AD.
Location of the manufacturer and its business address
Belgrade Road b/n, 26300, Vrsac, Serbia/Beogradski put bb, 26300,Vrsac, Serbia.
