Instructions Hepatrombin gel 50000 IU/100 g tube 40 g
Composition
active ingredient: heparin sodium;
100 g of cream contains heparin sodium 30,000 IU or 50,000 IU;
excipients: allantoin, dexpanthenol, disodium edetate, bronopol, hostaphate KW-340-N, lunacera M, carbomer 934, levomenthol, light mineral oil, glycerol monostearate, isopropyl myristate, white soft paraffin, triethanolamine, purified water.
Dosage form
Cream.
Main physicochemical properties: white homogeneous cream with a characteristic menthol odor.
Pharmacotherapeutic group
Agents used for varicose veins. Heparin or heparinoids for topical use. ATX code C05B A03.
Pharmacological properties
Pharmacodynamics
Hepatrombin, cream, is a high-dose heparin anticoagulant preparation for external use. It has a local antithrombotic, anti-edematous and anti-inflammatory effect, stimulates metabolic processes in tissues, as well as granulation and epithelialization of tissues, and improves local blood flow.
Pharmacokinetics
When applied externally, heparin does not have a systemic effect, quickly penetrates the skin and accumulates in the stratum corneum of the epidermis, and accordingly, has an exclusively local effect.
Indication
Treatment of superficial vein diseases such as varicose veins and related complications; phlebothrombosis, thrombophlebitis, superficial periphlebitis. Postoperative varicose phlebitis, complications after surgical removal of the saphenous veins of the lower extremities. Injuries and bruises, infiltrates and localized edema, subcutaneous hematomas. Injuries and sprains of musculo-tendon and capsulo-ligamentous structures.
Contraindication
Hypersensitivity to heparin or to any other component of the drug; bleeding trophic leg ulcers; open and/or infected wounds, hemorrhagic diathesis; purpura; thrombocytopenia; hemophilia. Bleeding tendency.
Interaction with other medicinal products and other types of interactions
No clinically significant interactions with other topical medicinal products have been reported, but they cannot be ruled out, especially with prolonged use, as heparin is known to penetrate intact skin.
Hepatrombin should not be used together with topical medications, such as those containing tetracycline, hydrocortisone, salicylic acid, or anticoagulants.
The use of heparin may contribute to prolongation of prothrombin time in patients taking oral anticoagulants.
An increased risk of bleeding cannot be ruled out. Hematomas may accumulate or become more widespread.
Application features
The cream should be applied only to intact skin. The drug should not be prescribed for bleeding, applied to infected areas of the skin in the presence of purulent processes, mucous membranes. If the patient has hemorrhagic symptoms, the possibility of using the drug should be carefully considered.
Hepatrombin contains bronopol, which may cause local skin reactions (e.g. contact dermatitis).
The cream should not be applied to wet skin, wounds, ulcers and blisters, eyes and areas around the eyes. If the cream accidentally gets inside, the child may experience nausea or vomiting. In this case, gastric lavage should be performed. Treatment is symptomatic.
In case of blood clotting disorders, the cream is not recommended to be applied to large areas of skin.
Use during pregnancy or breastfeeding
Do not use the medicine during pregnancy and breastfeeding.
Ability to influence reaction speed when driving vehicles or other mechanisms
Hepatrombin, cream, does not affect the reaction speed when driving or working with other mechanisms.
Method of administration and doses
Apply topically.
Treatment should be initiated with a dose of 50,000 IU/100 g, while a dose of 30,000 IU/100 g should be used to continue treatment.
Apply a layer of cream about 1 mm thick to and around the affected area 1–3 times a day and rub it lightly into the skin.
For vein diseases, a venous bandage can be applied.
In the case of treating phlebitis, the cream does not need to be rubbed into the skin, but only applied to the affected area in a layer about 1 mm thick and bandaged with an elastic bandage.
The duration of the treatment course is determined by the doctor individually depending on the course of the disease.
Children
Due to limited experience with the use of the drug, it should not be prescribed to children.
Overdose
Due to the low systemic absorption of the drug, there is no risk of overdose when applied topically. In case of accidental ingestion, nausea and vomiting may occur. Gastric lavage should be performed, and further treatment is symptomatic.
The effect of heparin can be neutralized with protamine sulfate.
Side effects
During the course of treatment, a hypersensitivity reaction to heparin or to any other component of the drug may develop. Signs of such hypersensitivity include itching, redness, swelling of the skin, burning sensation, skin rash, urticaria, angioedema, hemorrhages, sometimes the appearance of small pustules, vesicles or blisters. Systemic adverse reactions are possible when applied to large areas of the skin.
Expiration date
3 years.
Storage conditions
Store at a temperature not exceeding 25 °C.
Keep out of reach of children.
Packaging
40 g in a tube; 1 tube in a cardboard box.
Vacation category
Without a prescription.
Producer
"Hemofarm" AD / "Hemofarm" AD.
