Instructions Hepilor mouthwash bottle 100 ml
Composition
active ingredients: hexetidine, choline salicylate 80%, chlorobutanol hemihydrate;
100 ml of solution contain hexetidine in terms of 100% substance - 0.1 g, choline salicylate 80% in terms of 100% substance - 0.5 g, chlorobutanol hemihydrate in terms of 100% anhydrous substance - 0.25 g;
Excipients: ethanol 96%, sodium saccharin, polysorbate 20, propionic acid, lemon oil, anise oil, menthol (levomenthol), eucalyptol, purified water.
Dosage form
Oral solution.
Main physicochemical properties: transparent or slightly opalescent liquid with a specific aromatic odor and alcohol-anise taste.
Pharmacotherapeutic group
Means used for diseases of the throat. Antiseptics. ATX code R02A A20.
Pharmacological properties
Pharmacodynamics
The effect of the drug is due to three active ingredients.
Antibacterial and antifungal activity.
Hexetidine has an antibacterial effect on both gram-positive and gram-negative strains of microorganisms, both aerobes and anaerobes.
It should be noted that on aerobic strains it has mainly a bacteriostatic effect, the bactericidal effect is weak. On anaerobic strains hexetidine has a pronounced bactericidal effect. The mechanism of action is a competitive action with thiamine: the structure of hexetidine is similar to the structure of thiamine, which is necessary for the growth of microorganisms.
Anti-inflammatory activity.
Choline salicylate has analgesic, antipyretic and anti-inflammatory effects. For the treatment of oral diseases.
Analgesic activity is provided by chlorobutanol. It is used in otolaryngology (nose drops, rinses) and in dental practice (applications and irrigation) as an anesthetic.
Pharmacokinetics
The active substances are fixed on the mucous membrane of the oral cavity, from where they are gradually released.
Indication
Local treatment of infectious diseases and inflammatory processes of the oral cavity and pharynx: tonsillitis, acute and chronic tonsillitis, pharyngitis, laryngitis; gingivitis, stomatitis, aphthae.
Oral care after dental procedures.
Contraindication
Hypersensitivity to any component of the drug. Atrophic pharyngitis. Bronchial asthma or any other respiratory diseases associated with their hypersensitivity.
Interaction with other medicinal products and other types of interactions
Do not use together with preparations containing antiseptics (there may be an interaction with other antiseptic drugs). Hexetidine can be inactivated by alkaline solutions.
Application features
When using the drug, do not swallow it, avoid contact with eyes, and use with caution in patients with liver disease, as the drug contains ethanol.
The drug should be used with caution in patients with epilepsy. The drug may lower the epileptic threshold and cause seizures in children. Use with caution in patients with allergic reactions.
There is a risk of laryngospasm in children due to the presence of levomenthol.
Long-term use is not recommended as it may alter the natural microbial balance of the mouth and throat, where there is a risk of bacterial and fungal spread.
If general clinical signs of bacterial infection appear, general antibacterial therapy should be provided.
If symptoms persist for more than 5 days and/or body temperature increases, treatment with the drug should be discontinued and treatment tactics reviewed if inflammation increases.
Use during pregnancy or breastfeeding
There are no human studies on the possibility of hexetidine crossing the placenta and being excreted in breast milk, so the drug should not be used during pregnancy or breastfeeding.
Ability to influence reaction speed when driving vehicles or other mechanisms
The drug contains ethanol. Drivers are not recommended to drive a car for 30 minutes after using the drug.
Method of administration and doses
It is used as a topical mouthwash.
For one mouthwash for adults and children over 6 years of age: pour the solution into a measuring cup to the 10 ml mark and dissolve in 50 ml of warm water or dissolve 2 teaspoons of the drug in ¼ cup of warm water. 2 to 4 rinses per day. Do not swallow. The course of treatment is no longer than 5 days.
Children
Do not use the drug in children under 6 years of age.
Overdose
Absorption of a sufficient amount of Hepilor oral solution may result in alcohol intoxication due to the ethyl alcohol content.
The concentration of hexetidine contained in Hepilor oral solution is not toxic if the drug is used as directed.
There are no cases of excessive use of hexetidine leading to hypersensitivity reactions.
Treatment: symptomatic. If a child swallows the contents of the bottle, seek medical attention immediately. Gastric lavage should be considered within 2 hours of ingestion and measures should be taken to eliminate signs of alcohol intoxication.
Adverse reactions
Immune system disorders: hypersensitivity reactions, including urticaria, angioedema, laryngospasm, bronchospasm.
From the nervous system: ageusia, dysgeusia, change in taste sensations within 48 hours (the sensation of "sweet" can change to the sensation of "bitter" twice).
From the respiratory system, chest organs and mediastinum: cough, shortness of breath, feeling of a tickle in the throat.
On the part of the digestive system: dry mouth, dysphagia, enlargement of the salivary glands, pain when swallowing. In case of accidental ingestion of the drug, gastrointestinal disorders may occur, primarily nausea and vomiting.
Skin and subcutaneous tissue disorders: allergic contact dermatitis, skin reactions (rash).
General disorders and local manifestations: local reactions - reversible discoloration of the teeth and tongue; sensitivity of the mucous membrane, namely - burning, numbness; irritation (pain, feeling of heat, itching) of the tongue and/or mucous membrane of the oral cavity; decreased sensitivity; paresthesia of the mucous membrane; inflammation; blisters; ulceration of the mucous membrane, swelling at the site of contact, dryness of the nasal/throat mucous membrane.
If any adverse reactions occur, you should stop using the drug and be sure to consult a doctor.
Expiration date
3 years.
Do not use the drug after the expiration date indicated on the package.
Storage conditions
Store at a temperature not exceeding 25 ° C. Do not freeze.
Keep out of reach of children.
Packaging
100 ml in a bottle. 1 bottle in a pack.
Vacation category
Without a prescription.
Producer
PJSC "Farmak".
Location of the manufacturer and its business address
Ukraine, 04080, Kyiv, Frunze St., 74.
