Pharmacological properties
The pharmacological effect of the drug Chondr-Sila is due to the components that make up its composition - chondroitin sulfate and glucosamine hydrochloride.
Chondroitin sulfate is a high-molecular mucopolysaccharide that participates in the construction of cartilage tissue. Reduces the activity of enzymes that destroy articular cartilage and stimulates the regeneration of articular cartilage. Chondroitin sulfate reduces the activity of the inflammatory process in the early stages and thus slows down the degeneration of cartilage tissue. Helps reduce pain, improve joint function, and reduces the need for non-steroidal anti-inflammatory drugs in patients with osteoarthritis of the knee and hip joints.
Glucosamine hydrochloride has chondroprotective properties, reduces the deficiency of glycosaminoglycans in the body, participates in the biosynthesis of proteoglycans and hyaluronic acid. Due to its tropism for cartilage tissue, glucosamine hydrochloride initiates the process of sulfur fixation during the synthesis of chondroitin sulfate acid. Glucosamine hydrochloride selectively acts on articular cartilage, is a specific substrate and stimulator of the synthesis of hyaluronic acid and proteoglycans, inhibits the formation of superoxide radicals and enzymes that cause damage to cartilage tissue (collagenase and phospholipase), prevents the destructive effect of glucocorticoids on chondrocytes and impaired biosynthesis of glycosaminoglycans caused by NSAIDs.
Pharmacokinetics. Absorption. After a single oral administration of the drug in an average therapeutic dose, C max of chondroitin sulfate in blood plasma is achieved after 3-4 hours, in synovial fluid - after 4-5 hours. The bioavailability of chondroitin sulfate is 13%. Excretion is carried out mainly by the kidneys within 24 hours.
After oral administration, 90% of glucosamine is absorbed from the intestines, more than 25% enters the blood plasma into the cartilage tissue and synovial membranes of the joints. In the liver, part of the drug is metabolized to urea, carbon dioxide and water.
The bioavailability of glucosamine is 25% due to the first pass through the liver. The highest concentrations of glucosamine are determined in the liver, kidneys and articular cartilage. About 30% of the applied dose persists for a long time in bone and muscle tissues. It is excreted mainly with urine in unchanged form, partly with feces. T ½ is 68 hours.
Indication
Degenerative-dystrophic diseases of the joints and spine: osteoarthritis, shoulder-scapular periarthritis, osteochondrosis, fractures (to accelerate the formation of bone callus).
Application
Take the drug orally, drinking a small amount of water.
Adults and children over 12 years of age: 2 capsules 3 times a day. The minimum duration of treatment is 2 months. The course of treatment is usually repeated at 3-month intervals.
Contraindication
Increased individual sensitivity to any of the components of the drug, phenylketonuria, severe renal and hepatic dysfunction, diabetes mellitus, bleeding tendency, thrombophlebitis.
Side effects
General weakness, drowsiness, headache, insomnia, increased fatigue, dizziness, edema, gastrointestinal disorders: nausea, vomiting, abdominal pain, flatulence, diarrhea, constipation. Allergic reactions, including rash, itching, urticaria, erythema, dermatitis, eczema, angioedema.
Special instructions
Do not exceed the dose recommended by your doctor.
Use with caution in patients with hypersensitivity (allergy) to seafood.
At the beginning of treatment, it is appropriate for patients with diabetes to monitor blood sugar levels.
Use during pregnancy and breastfeeding. Adequate and well-controlled studies of the safety and efficacy of the drug during pregnancy or breastfeeding have not been conducted, therefore the use of the drug during this period is not recommended.
Children: There is no experience with the use of the drug in children, use is not recommended.
The ability to influence the reaction rate when driving vehicles or working with other mechanisms is unknown.
Interactions
When used in combination, it increases the absorption of tetracycline from the gastrointestinal tract and reduces the absorption of penicillins and chloramphenicol. It is compatible with non-steroidal anti-inflammatory drugs and glucocorticoids. When taking the drug Chondr-Sila, the need for non-steroidal anti-inflammatory drugs is reduced.
The effectiveness of treatment increases when the diet is enriched with vitamins A, C and salts of manganese, magnesium, copper, zinc, and selenium.
Overdose
Not described. In case of overdose, symptomatic treatment and gastric lavage are recommended.
Storage conditions
In the original packaging at a temperature not exceeding 25 °C.
