Ibuprofen 400 is a medicine that affects the musculoskeletal system. Anti-inflammatory and antirheumatic agent. Ibuprofen.
Warehouse
1 tablet contains 400 mg of ibuprofen; excipients: microcrystalline cellulose, croscarmellose sodium, lactose monohydrate, colloidal anhydrous silica, sodium lauryl sulfate, magnesium stearate, hypromellose, titanium dioxide (E 171), talc, macrogol 4000.
Contraindication
Hypersensitivity to ibuprofen or to any of the components of the drug.
History of hypersensitivity reactions (e.g. bronchial asthma, rhinitis, angioedema or urticaria) following previous use of ibuprofen, acetylsalicylic acid/aspirin or other NSAIDs.
Gastric and/or duodenal ulcer or gastrointestinal bleeding in active form, or history of recurrence (two or more severe episodes of ulcer or bleeding in the past).
Acute or previous inflammatory bowel diseases (such as Crohn's disease, ulcerative colitis).
History of gastrointestinal bleeding or perforation associated with previous NSAID use.
Method of application
The single dose for children aged 12 years and over with a body weight of > 40 kg and adults is 1 tablet (400 mg ibuprofen). If necessary, 1 tablet can be used every 6 hours. The maximum daily dose is 1200 mg (3 tablets per day). Use the minimum effective dose necessary to treat symptoms for the shortest possible period of time.
Application features
Patients with a history of gastrointestinal disorders, especially elderly patients, should report any unusual gastrointestinal symptoms (predominantly bleeding), especially gastrointestinal bleeding at the beginning of treatment.
In the event of gastrointestinal bleeding or ulceration in patients receiving ibuprofen, treatment should be discontinued immediately.
Pregnant women
Ibuprofen should not be taken during the first two trimesters of pregnancy unless clearly necessary.
Ibuprofen is contraindicated in the third trimester of pregnancy.
Children
Do not use in children under 12 years of age and weighing < 40 kg.
Drivers
After taking NSAIDs, undesirable effects such as dizziness, drowsiness, fatigue and visual disturbances are possible. If such effects occur during the use of NSAIDs, patients should not drive or operate other mechanisms.
Overdose
In most patients, symptoms of overdose develop within 4–6 hours after taking a significant amount of ibuprofen.
The most common symptoms of overdose include nausea, vomiting, abdominal pain, lethargy, and drowsiness.
Side effects
Infections and infestations: rhinitis, aseptic meningitis (especially in patients with pre-existing autoimmune disorders such as systemic lupus erythematosus and mixed connective tissue diseases) with symptoms of occipital rigidity, headache, nausea, vomiting, fever or disorientation.
From the blood and lymphatic system: aplastic anemia, leukopenia, thrombocytopenia, neutropenia, agranulocytosis, hemolytic anemia, which may occur with prolonged treatment, the first signs of which are fever, sore throat, superficial ulcers in the mouth, flu-like symptoms, severe exhaustion, bleeding of unknown origin and bruising.
From the nervous system: headache, dizziness, decreased sensitivity (especially in combination with alcohol), paresthesia, drowsiness.
From the organs of vision: visual impairment, toxic amblyopia, toxic optic neuropathy, optic neuritis.
On the part of the auditory organs and labyrinth disorders: hearing impairment, vertigo, with prolonged treatment, ringing in the ears and dizziness are possible.
Storage conditions
Store in the original packaging at a temperature not exceeding 30°C.
Keep out of reach of children.
