Instructions for Korneregel eye gel tube 5 g
Composition
active ingredient: dexpanthenol;
1 g of eye gel contains dexpanthenol 50 mg;
excipients: cetrimide, disodium edetate, carbomer, sodium hydroxide, water for injection.
Dosage form
Eye gel.
Main physicochemical properties: transparent, colorless gel.
Pharmacotherapeutic group
Medicinal products used in ophthalmology. ATX code S01X A12.
Pharmacological properties
Pharmacodynamics
Dexpanthenol/panthenol is an alcohol analogue of pantothenic acid, which has the same biological activity as pantothenic acid due to intermediate transformations, but it is better absorbed when applied topically. Pantothenic acid is a water-soluble vitamin that participates in various metabolic processes in the form of coenzyme A. Pantothenic acid is necessary for the formation and regeneration of the skin and mucous membranes. When applied topically, dexpanthenol/panthenol is able to compensate for the increased need for pantothenic acid in damaged skin or mucous membranes.
Pharmacokinetics
In pharmacokinetic studies of panthenol labeled with radioactive tritium, it was proven that the substance is characterized by reabsorption through the skin.
Indication
Non-infectious keratopathies, including corneal dystrophies, corneal degenerations, recurrent corneal erosions and prevention of corneal damage when using contact lenses.
Comprehensive treatment of corneal and conjunctival injuries, chemical and thermal burns.
In the complex therapy of infectious corneal lesions of bacterial, viral and fungal origin.
Contraindication
Hypersensitivity to any of the components of the drug.
Interaction with other medicinal products and other types of interactions
Unknown so far.
If Korneregel® is used together with other eye drops/eye ointments, there should be an interval of approximately 15 minutes between the administration of the drugs. In any case, Korneregel® should be instilled last.
Application features
Korneregel® should not be used to treat infectious corneal lesions of bacterial, viral and fungal origin as monotherapy; the drug should be used only as an adjunct in the complex therapy of these diseases.
Korneregel® contains the preservative cetrimide, which, especially with frequent or prolonged use, may cause eye irritation (redness, burning sensation and foreign body sensation in the eye) and may damage the corneal epithelium. For long-term treatment of chronic keratoconjunctivitis sicca, preservative-free medicinal products should be preferred.
Korneregel® should not be instilled while wearing contact lenses, as the lens material may be incompatible with the drug; they should be removed from the eye and reinserted no earlier than 10-15 minutes after instillation of Korneregel®.
Ability to influence reaction speed when driving vehicles or other mechanisms
Within a few minutes after instillation of Korneregel® into the conjunctival sac, temporary visual impairment may occur. It is not recommended to drive or operate complex machinery until visual acuity is restored.
Use during pregnancy or breastfeeding
Controlled studies of the use of the drug during pregnancy or breastfeeding have not been conducted. Animal studies have not revealed direct or indirect harmful effects of the drug on pregnancy, embryonal/fetal development, childbirth and postnatal development. The drug penetrates into breast milk. Therefore, if it is necessary to use the drug during pregnancy or breastfeeding, the doctor should carefully weigh the expected benefit of treatment with Korneregel® for the mother and the potential risk to the fetus/child.
Method of administration and doses
The drug is intended for topical use.
Depending on the severity and severity of symptoms, administer 1 drop into the conjunctival sac of the affected eye 4 times a day and before bedtime.
The drug should be used until the desired therapeutic effect is obtained.
The duration of the course of treatment depends on the clinical picture and is determined by the doctor individually.
To prevent contamination of the drug and the tip, do not touch the eyelids, the area around the eyes, or other surfaces during administration.
Children
The safety of the drug for the treatment of children has not been studied.
Overdose
Unknown.
Adverse reactions
Immediately after administration of the drug, temporary blurred vision is possible.
Vision disorders
Korneregel® contains the preservative cetrimide, which may cause eye irritation (redness, burning sensation and foreign body sensation in the eye) and damage the corneal epithelium. Other adverse reactions observed: pain, increased lacrimation, itching, conjunctival edema.
On the part of the immune system
Hypersensitivity reactions, including itching, rash, urticaria.
Expiration date
After first opening, the contents of the tube should be used within a maximum of 6 weeks.
Storage conditions
Store at a temperature not exceeding 25 °C out of the reach of children.
Packaging
5 g in a tube; 1 tube in a cardboard box.
Vacation category
Without a prescription.
Producer
Dr. Gerhard Mann Chem.-Pharm. Factory LLC.
Location of the manufacturer and its business address
Brunsbütteler Damm 165/173, 13581 Berlin, Germany.
