Lakozam tablets 50 mg No. 56

Lacosam is an antiepileptic drug. It is used as adjunctive therapy for the treatment of partial seizures, with or without secondary generalization, in patients aged 16 years and older with epilepsy.

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Contraindication

Hypersensitivity to the active substance or to excipients.

History of second or third degree atrioventricular block.

Method of application

The use of the drug can also be started with a single loading dose of 200 mg, followed by a maintenance dose of 100 mg twice a day (200 mg/day) approximately 12 hours later.

Application features

Lacosamide treatment is associated with dizziness, which may lead to an increased incidence of accidental injury and falls. Therefore, patients should be warned about the possible effects of the drug and caution should be advised.

Pregnant women

Lacosamide should not be used in pregnant women unless treatment is clearly necessary (if the benefit to the mother clearly outweighs the potential risk to the fetus).

Children

The drug is not recommended for use in children under 16 years of age, as the safety and effectiveness of the drug in these age groups have not been studied.

Drivers

Patients are advised not to drive or operate complex machinery until the patient's individual response to lacosamide is determined.

Overdose

There were no clinically significant differences between the type of adverse reactions observed in patients receiving doses above 400 mg and up to 800 mg and those observed in patients receiving therapeutic doses of lacosamide.

Reactions reported after ingestion of more than 800 mg are dizziness, nausea, vomiting, seizures (generalized tonic-clonic seizures, status epilepticus). Cardiac conduction disturbances, shock and coma have also been observed. Fatalities have been reported in patients after acute single overdose (intake of several grams of lacosamide).

Side effects

Blood and lymphatic system disorders: agranulocytosis.

On the part of the immune system: drug hypersensitivity, drug reaction with eosinophilia and symptoms of damage to various organ systems (DRESS).

Nervous system: dizziness, headache, balance disorders, memory impairment, cognitive disorder, drowsiness, tremor, nystagmus, hypoesthesia, dysarthria, disturbance in attention, paresthesia, fainting, coordination disorders.

Psychiatric disorders: depression, confusional state, insomnia, aggression, agitation, euphoric mood, psychotic disorder, suicide attempt, suicidal ideation, hallucinations.

From the organs of vision: diplopia, blurred vision.

Storage conditions

Store in the original packaging out of the reach of children. No special storage conditions required.