Instructions Larginus oral solution 200 mg/ml 100 ml can
Composition
active ingredient: arginine aspartate;
1 ml of solution contains arginine aspartate 200 mg;
excipients: sorbitol (E 420), sodium saccharin (E 954), methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), food flavoring "Caramel", purified water.
Dosage form
Oral solution.
Main physicochemical properties: yellowish liquid with a caramel odor.
Pharmacotherapeutic group
Other cardiological drugs. Amino acids.
ATX code C01E.
Pharmacological properties
Pharmacodynamics. "Larginus" has antihypoxic, cytoprotective, antioxidant, detoxification, membrane-stabilizing effects. It plays an important role in the processes of ammonia neutralization and stimulation of its excretion from the body, enhances the detoxification function of the liver. It has a hepatoprotective effect, positively affects the processes of energy supply in hepatocytes.
As a nitric oxide donor, Larginus participates in the processes of energy supply of the body, reduces the activation and adhesion of leukocytes and platelets to the vascular endothelium, preventing the formation and development of atherosclerotic plaques, and is involved in the processes of fibrinogenolysis and spermatogenesis.
The drug has a moderate anabolic effect, stimulates the activity of the thymus gland, promotes insulin synthesis and regulates blood glucose levels during physical exertion, and helps correct acid-base balance.
Pharmacokinetics: Not studied.
Indication
Use in complex therapy of atherosclerosis of the heart and brain vessels, arterial hypertension, atherosclerosis of peripheral vessels; chronic heart failure; hypercholesterolemia; chronic obstructive pulmonary diseases, pulmonary hypertension; asthenic conditions.
Contraindication
Hypersensitivity, severe renal impairment. Myocardial infarction (including history).
Interaction with other medicinal products and other types of interactions
When using arginine aspartate, it should be taken into account that the combined use of aminophylline with arginine may be accompanied by an increase in insulin levels in the blood, and spironolactone with arginine may be accompanied by an increase in potassium levels in the blood.
Arginine is incompatible with thiopental.
Application features
It should be used with caution in cases of electrolyte imbalance and kidney disease. When using the drug, it is necessary to adhere to a balanced sleep and rest regimen, and to avoid alcohol, nicotine, and psychostimulants. If symptoms of asthenia increase while taking the drug, treatment should be discontinued.
Use with caution in patients with angina pectoris.
Patients with hereditary fructose intolerance should not take the drug.
"Larginus" contains sorbitol (E 420) - if the patient has an intolerance to some sugars, you should consult a doctor before taking this medicine.
The medicine contains excipients such as methyl parahydroxybenzoate (E 218) and propyl parahydroxybenzoate (E 216), which may cause allergic reactions (possibly delayed).
This medicinal product contains less than 0.02 mmol (0.47 mg)/dose (5 ml) of sodium, i.e. essentially 'sodium-free'.
Use during pregnancy or breastfeeding
The drug penetrates the placenta, so it can be used during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.
There are no data on the use of the drug during lactation.
Ability to influence reaction speed when driving vehicles or other mechanisms
Does not affect.
Method of administration and doses
Administer orally, take with meals. Adults with atherosclerosis of the heart and brain vessels, atherosclerosis of peripheral vessels - 5 ml (1 measuring spoon - 1 g of the drug) 3-8 times a day. With hypercholesterolemia, arterial hypertension - 5 ml 3-6 times a day. With chronic obstructive pulmonary diseases, pulmonary hypertension - 5 ml 3-6 times a day. With asthenic conditions - 5 ml 4-8 times a day. The maximum daily dose is 8 g. The duration of the course of treatment is 8-15 days; if necessary, the course of treatment is repeated.
Children: Do not use in patients under 18 years of age.
Overdose
Symptoms: hypersensitivity reactions, hypoglycemic states.
Treatment. If these symptoms occur, it is necessary to stop taking the drug. Gastric lavage and sorbents are indicated. There is no antidote. Symptomatic therapy.
Adverse reactions
Musculoskeletal system: joint pain.
On the part of the digestive tract: rarely - a feeling of mild discomfort in the stomach and intestines, nausea immediately after taking the drug, which disappear on their own.
Immune system disorders: hypersensitivity reactions, including bronchospasm.
Reporting adverse reactions after registration of a medicinal product is of great importance. This allows monitoring of the benefit/risk ratio when using this medicinal product. Medical and pharmaceutical professionals, as well as patients or their legal representatives, should report all cases of suspected adverse reactions and lack of efficacy of the medicinal product via the automated pharmacovigilance information system at the link: https://aisf.dec.gov.ua
Expiration date
2 years.
The shelf life after opening the can is 14 days.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children. Do not freeze.
Incompatibility
Arginine is incompatible with thiopental.
Packaging
100 ml in a jar; 1 jar with a measuring spoon in a cardboard pack.
Vacation category
Without a prescription.
Producer
Technolog PJSC.
Location of the manufacturer and its business address
Ukraine, 20300, Cherkasy region, Uman city, Stara Prorizna Street, building 8.
